Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0279530 (
bone cancer
)
1,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Background Cancer-induced pain (CIP) is one of the most severe types of chronic pain with which clinical treatment remains challenging and the involved mechanisms are largely unknown.
Suppressor of cytokine signaling 3
(
SOCS3
) is an important intracellular protein and provides a classical negative feedback loop, thus involving in a wide variety of processes including inflammation and nociception. However, the role of
SOCS3
pathway in CIP is poorly understood. The present study was designed to investigate the role of
SOCS3
in dorsal root ganglion (DRG) in the development of CIP. Method CIP was established by injection of Walker 256 mammary gland tumor cells into the rat tibia canal. Whole-cell patch clamping and Western blotting were performed. Results Following the development of
bone cancer
,
SOCS3
expression was significantly downregulated in rat DRGs at L2-L5 segments. Overexpression of
SOCS3
, using lentiviral-mediated production of
SOCS3
at spinal cord level, drastically attenuated mechanical allodynia and body weight-bearing difference, but not thermal hyperalgesia in
bone cancer
rats. In addition, overexpression of
SOCS3
reversed the hyperexcitability of DRG neurons innervating the tibia, and reduced abnormal expression of toll-like receptors 4 in the DRGs. Conclusions These results suggest that
SOCS3
might be a key molecular involved in the development of complicated cancer pain and that overexpression of
SOCS3
might be an important strategy for treatment for mechanical allodynia associated with
bone cancer
.
...
PMID:Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats. 2832 31
