Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0279530 (
bone cancer
)
1,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The correlation between mitogen-activated protein kinase (MAPK)/P53 signaling-dependent
fatty acid synthase
(
FASN
) expression and bone tumors was examined in the present study. We established the SH081 bone tumor cell line, which was used to determine the expression of
FASN
and MAPK/P53 at the mRNA and protein levels in bone tumor cells and normal cells. Compared with the normal cells, the expression of MAPK/P53 and
FASN
mRNA was significantly elevated, whereas inhibition of MAPK/P53 decreased
FASN
expression. Similarly, the expression of
FASN
and MAPK/P53 proteins were significantly elevated in the bone tumor cells and treatment with the MAPK/P53 inhibitor decreased the expression of
FASN
. To determine the role of MAPK/P53 in cell proliferation,
bone cancer
cells were treated with MAPK/P53 inhibitor and the results showed a reduced proliferation rate. Thus,
FASN
promotes the development of bone tumors and MAPK/P53 signaling contributes to bone tumors by upregulating the expression of
FASN
.
...
PMID:MAPK/P53-mediated FASN expression in bone tumors. 2858 96
