Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278883 (metastatic melanoma)
 6,224 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
C21orf34 12.3
Mdm4 p53 binding protein homolog 12.3
SSX4B 12.3
hypothetical protein FLJ11151 12.3
SSX4 protein 12.3
TCRAV2S1 11.7
ZNF490 11.3
C7orf4 11.3
SCD5 protein 11.3
REG1A protein 11.3
LOC642587 11.3
P2RY10 11.3
transmembrane protein 31 11.3
NRAS1 11.0
small nuclear ribonucleoprotein polypeptide A 10.7
LINGO3 10.7
ovostatin 2 10.7
GON4L 10.7
FAM41C 10.7
RIP5 10.7
Flotillin 2 10.7
ZSWIM7 10.7
GPNMB protein 10.3
KRTCAP3 10.3
renal cell carcinoma 4 10.3
hPARP-3 10.3
MIA protein 10.3
developmentally regulated GTP-binding protein 2 10.0
AP-2B 10.0
EYA1 protein 10.0
cytotoxic T-lymphocyte protein 4 10.0
THBS1 protein 10.0
KDELR3 10.0
MAGE2 10.0
microphtalmia-associated transcription factor 9.9
TM9SF4 9.9
MAGE3 9.8
ATP-binding cassette sub-family B member 5 9.7
ORC5L 9.7
APO B-100 9.7
EVPL 9.7
SSX5 9.5
eukaryotic translation initiation factor 4H 9.5
TSPAN10 9.5
M-phase phosphoprotein 8 9.5
NUPL2 9.5
MED27 9.5
aldesleukin 9.4
GPR160 9.3
SSX3 9.3
AGAP3 9.3
SECTM1 9.3
BRMS1 protein 9.3
ZNF827 9.3
P4HA3 9.3
TMEM79 9.3
NKTR 9.2
DNAJB4 9.2
v-raf murine sarcoma viral oncogene homolog B1 9.2
MART-1 9.2
gp100 9.2
Phospholipase D4 9.2
NEK11 9.2
HLA-Cw*0702 9.2
BBAP 9.2
developmentally regulated GTP-binding protein 1 9.2
TMEM45B 9.2
HPSE 9.1
MCAM 9.1
cytotoxic T-lymphocyte antigen 4 9.1
MAGE-3 9.1
CLTA 9.0
MART1 9.0
IFN-alpha 6 9.0
CEP350 9.0
DPF1 9.0
calcyclin binding protein 9.0
BRAF 8.9
melanoma antigen MART-1 8.9
GJC3 8.9
more...
Disease
Craniopharyngeal duct 12.3
metastatic melanoma 12.3
Craniopharyngeal duct 12.3
Craniopharyngeal duct 12.3
Cervical melanoma 11.3
Metastatic malignant melanoma 10.8
pediatric oligodendroglioma 10.7
Polyradiculoneuritis 10.7
stage IV melanoma 10.6
malignant nevus 10.3
stage III melanoma 10.2
Melanoma-associated retinopathy 10.1
Dorsal midbrain syndrome 10.0
benign nevi 9.7
Lumbosacral radiculopathy 9.5
Tumor ulceration 9.5
recurrent melanoma 9.5
Neutrophilic panniculitis 9.4
Clear cell sarcoma of tendons and aponeuroses 9.3
Melanoma 9.2
cancer regression 9.2
Acquired generalized lipodystrophy 9.2
Pituitary macroadenoma 9.0
Desmoplastic malignant melanoma 9.0
Autoimmune hypophysitis 8.9
stage I melanoma 8.8
superficial spreading malignant melanoma 8.7
Derailment 8.7
melanoma in situ 8.6
melanoma stage 8.5
CIIP 8.5
Mixed tumor 8.5
dysplastic nevi 8.5
cutaneous melanoma 8.5
Autoimmune myocarditis 8.4
melanoma 8.4
Malignant blue nevus 8.3
halo nevus 8.3
ocular melanoma 8.2
Hypophysitis 8.2
Eosinophilic myocarditis 8.2
ophiasis 8.2
Conjunctival melanoma 8.0
pigmented skin lesion 8.0
Acral lentiginous melanoma 8.0
Melanotic schwannoma 8.0
compound nevus 7.9
Hutchinson's sign 7.9
multiple nevi 7.8
nodular malignant melanoma 7.8
Cutaneous endometriosis 7.7
blue nevus 7.7
Clear cell sarcoma 7.6
brain metastases 7.6
CNS metastases 7.5
stage II melanoma 7.5
melanosis 7.5
glycosphingolipidoses 7.5
Adrenal metastases 7.5
uveal melanoma 7.2
Neutrophilic eccrine hidradenitis 7.2
Ciliary body 7.0
Ciliary body 7.0
Spitz nevus 7.0
evaluable disease 7.0
Triton tumor 6.9
recurrent osteosarcoma 6.8
Cerebral metastases 6.8
Vogt-Koyanagi 6.8
skin cancer 6.7
reticulohistiocytoma 6.6
poliosis 6.6
muscle neoplasm 6.6
intradermal nevus 6.6
junctional nevus 6.6
recurrent renal cell carcinoma 6.6
keratoacanthoma 6.5
measurable disease 6.5
Angiomatoid fibrous histiocytoma 6.5
salivary gland adenocarcinoma 6.5
more...
Symptom
Local swelling 8.6
Cullen's sign 7.9
Murphy's sign 6.4
brittle nails 6.3
non-productive cough 5.2
generalized rash 5.2
rigors 5.0
chills 4.9
jaw pain 4.8
eye pain 4.8
orthopnea 4.5
arthralgia 3.9
testicular pain 3.9
loss of taste 3.8
asthenia 3.8
decreased appetite 3.7
nausea 3.7
nausea and vomiting 3.7
intestinal bleeding 3.7
clubbing 3.5
oliguria 3.5
myalgia 3.4
syncopal episodes 3.3
dry skin 3.3
blurred vision 3.3
abdominal cramps 3.3
adenitis 3.2
night sweats 3.1
fatigue 3.1
acute abdomen 3.1
tonic-clonic seizure 3.0
leg edema 2.9
exertional dyspnea 2.9
right upper quadrant pain 2.9
erythema 2.8
diarrhea 2.8
chronic back pain 2.8
anorexia 2.7
vomiting 2.7
bone pain 2.7
photophobia 2.7
exhaustion 2.7
abdominal pain 2.5
muscle cramps 2.5
constipation 2.5
productive cough 2.2
cachexia 2.2
nasal congestion 2.2
lethargy 2.2
dental pain 2.1
paresthesia 2.0
Ill 2.0
tingling 2.0
shortness of breath 2.0
pelvic pain 1.9
hepatomegaly 1.8
dyspnea 1.8
hemoptysis 1.7
colic 1.7
ophthalmoplegia 1.6
epigastric pain 1.6
abdominal discomfort 1.6
back pain 1.6
hip pain 1.5
acute abdominal pain 1.4
tinnitus 1.2
polydipsia 1.2
syncope 1.1
stridor 1.1
vertigo 1.1
weakness 1.0
dry eye 1.0
discomfort 0.9
headache 0.9
paresis 0.8
hoarseness 0.8
cough 0.8
HSA 0.8
discomfort 0.7
polyuria 0.7
more...
Drug
Ecromeximab 12.3
Ipilimumab 11.0
Vaccinia immune globulin 10.7
Canvaxin 10.2
Zeniplatin 10.0
Fotemustine 9.6
Proleukin 9.6
Temodal 9.1
Carbetimer 9.0
Peginterferon alfa-2b 7.8
Peginterferon alfa-2b 7.8
Sodium dichloroacetate 7.7
Provenge 7.5
Genasense 7.5
Bleomycins 7.2
Lonafarnib 7.1
Intron A 6.9
Leukine 6.9
Intron A 6.8
Paraplatin 6.8
Cerezyme 6.5
Midostaurin 6.3
Bexxar 6.2
Cilengitide 6.2
Ceredase 6.1
Velban 6.1
Omniscan 5.9
Thymopentin 5.9
Tirapazamine 5.9
PDL 5.8
Ferumoxytol 5.7
Cerezyme 5.6
Imiquimod 5.6
Nexavar 5.6
Ethyol 5.5
Intron A 5.5
Vindesine 5.5
Vindesine 5.4
Plavix 5.4
TFT 5.3
Zevalin 5.3
CDX 5.3
Omniscan 5.2
BLM 5.1
Interferon beta 5.1
Dasatinib 5.1
Lenalidomide 5.0
IL-2 4.9
CDX 4.9
Bexarotene 4.9
Navelbine 4.8
Deferasirox 4.7
Idarubicin 4.6
Sorafenib 4.6
RAL 4.3
Zoladex 4.3
GNA 4.2
ID2 4.2
Gastro 4.1
Taxotere 4.0
Zoladex 4.0
VCR 4.0
p75 4.0
Auranofin 3.9
Bevacizumab 3.9
Amifostine 3.8
TRM 3.8
Bortezomib 3.8
Infliximab 3.8
Infliximab 3.8
SPP 3.8
Orlistat 3.7
Taxol 3.7
Imatinib 3.6
Dihydrotestosterone 3.6
Bosentan 3.6
Bosentan 3.6
Vinorelbine 3.6
CCL 3.6
Adenosine triphosphate 3.5
more...
Enzyme
N-acetylneuraminylgalactosylglucosylceramide 8.4
prolyl 3-hydroxylase 7.7
MEK 6.6
nicotinic acid phosphoribosyltransferase 6.1
tyrosinase 6.1
RGP 6.1
EC 4.4.1.5 6.1
adamalysin 6.0
cancer procoagulant 5.8
N-acetylglucosaminyltransferase III 5.7
coagulation factor VIIa 5.7
quinolinic acid phosphoribosyltransferase 5.6
DCF 5.6
calpain 3 5.1
N-acetylglucosaminyltransferase V 5.0
neuropsin 5.0
methioninase 5.0
methionine synthase reductase 4.7
calpain 3 4.6
methylthioadenosine phosphorylase 4.5
oxytocinase 4.5
eEF2 kinase 4.4
sphingomyelin synthase 4.4
spermidine/spermine N1-acetyltransferase 4.4
MEKK1 4.3
estrogen sulfotransferase 4.2
hyaluronate lyase 4.0
granzyme B 4.0
matrix metalloproteinase 2 4.0
PNL 3.9
methionine adenosyltransferase 3.9
argininosuccinate synthetase 3.9
lactate dehydrogenase 3.9
caspase-4 3.8
mitogen-activated protein kinase 3.8
cathepsin H 3.8
nicotinamide phosphoribosyltransferase 3.8
ubiquitin-protein ligase 3.7
caspase-4 3.6
galactocerebrosidase 3.6
lactic acid dehydrogenase 3.5
polyamine oxidase 3.5
STK11 3.5
ERK 3.4
lactic acid dehydrogenase 3.4
glucosylceramide synthase 3.4
Hageman factor 3.3
cathepsin B 3.3
matrix metalloproteinase 9 3.2
isopeptidase 3.2
CCS 3.1
thioredoxin reductase 3.1
cysteine synthase 3.0
caspase-9 3.0
factor C 3.0
neutral sphingomyelinase 2.9
CPM 2.9
fatty acid desaturase 2.9
MMP 2.9
ribonucleotide reductase 2.8
indoleamine 2,3-dioxygenase 2.8
polynucleotide phosphorylase 2.8
exoribonuclease 2.8
MAP 2.8
arginase 2.8
ribonucleotide reductase 2.8
SST 2.7
sialyltransferase 2.7
lactic acid dehydrogenase 2.7
caspase-2 2.7
sialyltransferase 2.7
sialyltransferase 2.7
thyroid peroxidase 2.7
caspase-2 2.7
PAT 2.6
focal adhesion kinase 2.6
beta-secretase 2.5
caspase-7 2.5
caspase-7 2.5
Rex 2.5
more...
Compound
4-acetylbenzoic acid 9.5
2-acetylbenzoic acid 9.5
HBPA 9.2
Cirsiliol 9.0
8-aminooctanoic acid 8.9
4-Methylcatechol 8.5
Diphenylcyclopropenone 8.4
Chlorozotocin 8.2
3-phenylpropanamide 8.2
M1A 8.0
DIBA 7.9
DIC 7.9
aminomalonic acid 7.9
Temozolomide 7.7
Hinokitiol 7.4
Bixin 7.1
Bixin 7.1
2-AA 7.1
Interleukin-2 7.1
MEK 7.0
Neu5,9Ac2 6.9
CI-921 6.9
Tomatine 6.9
PCNU 6.8
Flavone acetic acid 6.6
Thiostrepton 6.5
GD3 6.5
EGT 6.4
Velban 6.4
NOXA 6.4
BIF 6.0
Deguelin 6.0
BCNU 5.9
Deoxyguanosine 5.9
Melanin 5.8
PGE3 5.8
Estramustine 5.8
Parthenolide 5.7
Diallyl disulfide 5.6
Diallyl disulfide 5.6
IAN 5.6
Pyrimethamine 5.6
Reticulin 5.6
methyl butyrate 5.5
Acivicin 5.5
Mangiferin 5.4
Parthenolide 5.4
Indirubin 5.4
Toremifene 5.4
Galangin 5.4
Gambogic acid 5.3
TFT 5.3
Lansoprazole 5.2
2-Deoxy-D-glucose 5.2
benzenesulfonyl fluoride 5.1
Lupeol 5.0
Buthionine sulfoximine 5.0
Pimozide 4.9
Withaferin A 4.8
Pterostilbene 4.8
MNT 4.8
N-(4-hydroxyphenyl)retinamide 4.8
DLT 4.8
Sanguinarine 4.8
OPE 4.8
WR-1065 4.7
P2A 4.7
VLA 4.6
11,12-EET 4.5
12(S)-HETE 4.5
Lipoxin A4 4.5
Celecoxib 4.4
MGBG 4.4
MGBG 4.4
TEPA 4.3
LCR 4.2
TAP 4.2
ATF 4.2
BLM 4.2
CBDCA 4.2
more...