Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278883 (metastatic melanoma)
 6,224 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
BRAF 917
Sep 335
MEK 324
interleukin-2 287
PD-1 259
Mol 251
CTLA-4 208
CD8 201
cytokine 192
interferon 181
IL-2 166
PD-L1 139
tyrosinase 127
CD4 120
IFN 116
MAPK 115
HLA 115
NRAS 107
gp100 107
p53 104
nodal 103
lymphocyte antigen 99
MART-1 94
ERK 80
AKT 79
lactate dehydrogenase 79
F10 75
PI3K 71
Melan-A 69
RAF 67
HLA-A2 65
PD1 64
vascular endothelial growth factor 61
CTLA4 60
She 60
interferon-alpha 59
S100 57
KIT 56
interleukin 2 55
tumor necrosis factor 51
collagen 51
FDG 50
lymphokine 50
IFN-gamma 48
MRI 47
Bcl-2 47
tyrosine kinase 45
lymphoid 44
IL-6 44
TNF 44
fibronectin 42
MHC 42
PTEN 41
glycoprotein 41
GM-CSF 41
matrix metalloproteinase 40
HLA-DR 39
MHC class I 38
p21 36
MEL 36
E-cadherin 35
interferon alpha 35
mTOR 35
melanoma antigen 34
TCR 34
c-kit 34
MITF 33
major histocompatibility complex 33
caspase-3 33
T cell receptor 31
interferon-gamma 31
IL-10 31
cytotoxic T-lymphocyte antigen 4 30
microphthalmia-associated transcription factor 30
ERK1 30
catenin 30
VEGF 30
IL-8 30
extracellular signal-regulated kinase 30
cytotoxic T-lymphocyte-associated antigen 4 29
granulocyte-macrophage colony-stimulating factor 29
ATP 28
insulin 28
B-RAF 27
chemokine 27
vimentin 27
melanoma-associated antigen 27
programmed cell death 1 27
LDH 26
MMP-2 26
proto-oncogene 26
CD25 26
granulocyte 26
human leukocyte antigen 25
CD28 25
IL2 25
Cytokine 25
CD146 25
endoplasmic reticulum 24
IL-4 24
HLA class I 24
CD56 23
MAGE-3 23
p27 22
MAGE 22
4-1BB 21
IL-2 receptor 21
TNF-alpha 21
MEK1 21
beta 1 21
histone 20
CD44 20
survivin 20
fused 20
lipopolysaccharide 20
CD34 19
MAP kinase 19
proteasome 19
Ki-67 19
p38 19
p16 19
STAT3 18
cyclin D1 18
CCR7 18
protein B 18
Tyrosinase 18
CD45 18
macrophage colony-stimulating factor 17
NY-ESO-1 17
IL-15 17
annexin V 17
GNAQ 17
adhesion molecule 17
S100B 17
ICAM-1 17
Mcl-1 16
epidermal growth factor 16
Rho 16
TRAIL 16
heparanase 16
EGFR 16
gut 16
SOX10 16
CSF 16
CD68 16
CDKN2A 16
NMR 15
nerve growth factor 15
VEGFR2 15
MCAM 15
metastasis suppressor 15
NKG2D 15
p75NTR 15
serine/threonine kinase 15
CDK4 15
CD20 15
vascular endothelium 15
colon carcinoma 15
P-glycoprotein 14
focal adhesion kinase 14
more...
Disease
metastatic melanoma 6224
melanoma 4450
cancer 2595
tumor 2463
metastases 1235
Melanoma 912
cutaneous melanoma 261
skin cancer 260
mole 250
tumor growth 241
tumor progression 222
brain metastases 171
carcinoma 133
renal cell carcinoma 130
stage IV melanoma 121
primary tumor 119
tumorigenesis 95
breast cancer 85
mole 84
colitis 79
lung cancer 79
benign nevi 76
rash 69
sarcoma 65
lung metastases 64
non-small cell lung cancer 63
vitiligo 60
adenocarcinoma 59
dysplastic nevi 57
squamous cell carcinoma 56
lymphoma 51
thrombocytopenia 47
uveal melanoma 46
leukemia 43
metastatic renal cell carcinoma 42
hepatitis 41
neutropenia 38
stage III melanoma 38
solid tumor 37
colorectal cancer 35
liver metastases 35
melanosis 34
dermatitis 33
aggressiveness 32
glioma 31
prostate cancer 31
carcinogenesis 31
myelosuppression 30
hepatocellular carcinoma 29
renal cancer 29
mimicry 29
lung carcinoma 27
pruritus 27
lymphadenopathy 26
melanoma in situ 26
multiple myeloma 25
pneumonia 24
ovarian cancer 24
photosensitivity 23
ocular melanoma 23
Hodgkin's disease 23
intussusception 22
anemia 22
plaque 21
influenza 21
uveitis 20
hypothyroidism 19
colon cancer 19
aggression 19
recurrent melanoma 19
blue nevus 18
HIV 18
basal cell carcinoma 18
sarcoidosis 18
fibrosarcoma 18
herpes simplex 18
neuroblastoma 18
neuropathy 18
bowel obstruction 17
cancer regression 16
SCID 16
bone metastases 16
myocarditis 16
systemic disease 16
Blocking 16
panniculitis 15
keratosis 15
glioblastoma 15
measurable disease 15
Metastatic malignant melanoma 15
head and neck cancer 15
sepsis 14
thyroiditis 14
cold 14
sepsis 14
lentigo 14
autoimmune disease 14
heart failure 14
skin disease 13
residual disease 13
keratoacanthoma 13
keratosis 13
acute myeloid leukemia 13
diabetes 13
lymphopenia 13
enterocolitis 13
hematologic malignancies 13
glioblastoma multiforme 13
schwannoma 13
tumor angiogenesis 12
leukopenia 12
vaccinia 12
chronic myeloid leukemia 12
hepatitis B 12
brain tumor 12
lymphocytosis 11
hyperthyroidism 11
stromal tumors 11
confusion 11
EMA 11
infectious diseases 11
non-Hodgkin's lymphoma 11
hyperkeratosis 11
Epstein 11
metastatic breast cancer 11
CNS metastases 11
tumor vasculature 11
pancreatic cancer 11
vasculitis 10
psoriasis 10
myositis 10
encephalitis 10
chronic lymphocytic leukemia 10
B-cell lymphoma 10
pancreatitis 10
gastrointestinal stromal tumor 10
epithelial ovarian cancer 10
myasthenia gravis 10
retinopathy 10
renal failure 10
leiomyosarcoma 10
Still 9
EMT 9
NOD 9
amelanotic melanoma 9
Parkinson's disease 9
skin metastases 9
astrocytoma 9
adenoma 9
MDI 9
BLM 9
virus infection 9
immunodeficiency 9
multiple sclerosis 9
bladder cancer 9
hypertension 8
peripheral neuropathy 8
DDP 8
Merkel cell carcinoma 8
herpes 8
more...
Symptom
fatigue 85
diarrhea 78
nausea 60
vomiting 41
pain 38
abdominal pain 35
chills 25
nausea and vomiting 24
arthralgia 21
headache 20
dyspnea 19
erythema 18
anorexia 18
exhaustion 17
weakness 15
myalgia 14
constipation 11
seizures 9
Ill 9
discomfort 8
discomfort 8
cough 8
asthenia 7
back pain 7
collapse 6
anesthesia 6
exertional dyspnea 5
acute abdomen 5
lethargy 5
cachexia 5
rigors 5
blurred vision 4
starvation 4
syncope 4
hemoptysis 4
hepatomegaly 4
paresthesia 4
acidity 4
shortness of breath 4
bone pain 4
oliguria 4
dizziness 3
pelvic pain 3
respiratory distress 3
tinnitus 3
decreased appetite 3
vertigo 3
clubbing 2
ophthalmoplegia 2
sleepiness 2
intestinal bleeding 2
tonic-clonic seizure 2
night sweats 2
eye pain 2
ataxia 2
dry skin 2
colic 2
epigastric pain 2
non-productive cough 2
orthopnea 2
chest pain 2
low back pain 2
agitation 2
photophobia 2
paresis 2
loss of taste 1
stridor 1
angina 1
right upper quadrant pain 1
tingling 1
analgesia 1
productive cough 1
testicular pain 1
flushing 1
generalized rash 1
HSA 1
dental pain 1
hip pain 1
polyuria 1
tremor 1
overweight 1
hoarseness 1
leg edema 1
acute abdominal pain 1
jaw pain 1
numbness 1
insomnia 1
syncopal episodes 1
dry eye 1
abdominal discomfort 1
brittle nails 1
thinning 1
muscle cramps 1
Cullen's sign 1
Murphy's sign 1
chronic back pain 1
abdominal cramps 1
cerebellar ataxia 1
polydipsia 1
nasal congestion 1
adenitis 1
splenomegaly 1
Local swelling 1
Drug
Dermatol 372
IL-2 170
Ipilimumab 164
CSF 48
IFN-gamma 47
p75 12
MAP 12
ROS 11
Fotemustine 10
BLM 9
lysine 8
Taxol 8
Sorafenib 7
CAM 7
PDL 7
Imatinib 6
Temodal 5
Proleukin 5
Bevacizumab 5
Imiquimod 5
IFN-beta 5
Monit 4
Dasatinib 4
Bortezomib 4
Cardiovasc 4
Lenalidomide 4
GEO 3
Activin 3
Spectrum 3
Spectrum 3
Adriamycin 3
ADM 3
Intron A 3
VCR 3
ETS 3
ABC 3
Glutathione 3
Histamine 3
Leaf 3
ascorbate 3
CCL 3
Gastro 3
Infliximab 3
Infliximab 3
Fragment 3
Intron A 3
ACT 2
Albumin 2
NADH 2
Alliance 2
Adenosine triphosphate 2
Genasense 2
CTC 2
VCR 2
CTC 2
L-tyrosine 2
Canvaxin 2
CTX 2
balanced salt solution 2
uPA 2
Fluorescein 2
Docetaxel 2
Taxotere 2
CDX 2
Provenge 2
Gleevec 2
Gefitinib 2
Gel 2
NVP 2
TFT 2
Bifidobacterium 2
CDX 2
FAD 1
Cerezyme 1
NaI 1
Deferasirox 1
Gelatin 1
Bexarotene 1
Methylene blue 1
Zoladex 1
PCB 1
Ceredase 1
Amiloride 1
Vitamin B 1
Mutagen 1
ALA 1
Asn 1
Interferon beta 1
Orlistat 1
G-CSF 1
Vindesine 1
Zoladex 1
Peginterferon alfa-2b 1
Denosumab 1
Fluorescein 1
Navelbine 1
Vaccinia immune globulin 1
Diphenhydramine 1
CPM 1
Auranofin 1
Retinoic acid 1
NAG 1
Midostaurin 1
CPT-11 1
Velban 1
EPA 1
Zeniplatin 1
Nexavar 1
Herceptin 1
NaI 1
Bayer 1
Erlotinib 1
Zoledronic acid 1
TRM 1
R1881 1
ID2 1
Oxaliplatin 1
Cerezyme 1
Salicylate 1
Clopidogrel 1
Parkin 1
NaI 1
Plavix 1
ROC 1
lactose 1
Ecromeximab 1
Bleomycins 1
Tirapazamine 1
Peginterferon alfa-2b 1
Ferumoxytol 1
Lovastatin 1
DNase I 1
RAL 1
Asthma 1
Lonafarnib 1
Biopolymers 1
Bexxar 1
NaI 1
Idarubicin 1
Sodium dichloroacetate 1
Ethanol 1
Amifostine 1
Thymopentin 1
Portal 1
ICI 1
G418 1
Carbetimer 1
Ethyol 1
Omniscan 1
Omniscan 1
DMI 1
Cilengitide 1
TTC 1
Rituximab 1
Zoledronic acid 1
Parkin 1
Intron A 1
Paraplatin 1
BCG vaccine 1
Dihydro 1
more...
Enzyme
MEK 349
mitogen-activated protein kinase 264
ERK 202
tyrosinase 122
lactate dehydrogenase 84
protein kinase 53
focal adhesion kinase 51
protein kinase C 28
reverse transcriptase 27
caspase-3 26
proteasome 19
DCF 19
luciferase 17
P-glycoprotein 14
PARP 12
caspase-9 12
collagenase 11
granzyme B 10
MAP 10
thrombin 9
urokinase-type plasminogen activator 9
phosphatidylinositol 3-kinase 9
RNA polymerase 9
lipase 8
cathepsin B 8
transcriptase 7
MEKK1 7
aspartate aminotransferase 7
alanine aminotransferase 7
matrix metalloproteinase 2 7
NO synthase 6
alkaline phosphatase 6
ACS 6
MMP 6
peroxidase 6
NADPH oxidase 5
caspase-1 5
cdc2 5
AMP-activated protein kinase 5
arginase 5
calcineurin 5
phosphodiesterase 5
ATPase 5
NADPH oxidase 5
catalase 5
GSK 4
guanylate cyclase 4
thyroid peroxidase 4
caspase-8 4
AMPK 4
tissue plasminogen activator 4
phosphoinositide 3-kinase 4
adenylate cyclase 4
plasmin 4
APC 4
phospholipase C 4
ribonucleotide reductase 4
matrix metalloproteinase 9 4
ribonucleotide reductase 4
IKK 4
glutathione reductase 4
thioredoxin reductase 4
transglutaminase 4
glutathione S-transferase 3
RGP 3
AMPK 3
enolase 3
hexokinase 3
AST 3
CD10 3
cathepsin D 3
trypsin 3
calpain 3 2
renin 2
DNA methyltransferase 2
methionine adenosyltransferase 2
thymidylate synthase 2
chloramphenicol acetyltransferase 2
demethylase 2
thymidine kinase 2
ubiquitin-protein ligase 2
chymotrypsin 2
DNase 2
thromboplastin 2
CD13 2
PDE 2
acid phosphatase 2
argininosuccinate synthetase 2
ricin 2
adenosine deaminase 2
glutaminase 2
DNA ligase 2
gamma-glutamyl transpeptidase 2
adenosine deaminase 2
MMP-3 2
elastase 2
isocitrate dehydrogenase 2
DNA ligase 2
isocitrate dehydrogenase 2
topoisomerase 2
sialyltransferase 2
topoisomerase 2
indoleamine 2,3-dioxygenase 2
CDR 2
sialyltransferase 2
MIP 2
superoxide dismutase 2
estrogen sulfotransferase 2
beta-glucuronidase 2
sialyltransferase 2
caspase-2 1
NOS 1
glutathione peroxidase 1
caspase-4 1
polynucleotide phosphorylase 1
caspase-7 1
deoxyribonuclease 1
PAT 1
methioninase 1
caspase-7 1
protein phosphatase 2A 1
CPT 1
sphingomyelin synthase 1
cysteine synthase 1
polyamine oxidase 1
Rex 1
UDP-glucuronosyltransferase 1
CPM 1
STK11 1
CYP3A4 1
EC 4.4.1.5 1
lysozyme 1
neuraminidase 1
CPT 1
isopeptidase 1
pyruvate kinase 1
caspase-2 1
lactic acid dehydrogenase 1
firefly luciferase 1
RNase 1
histidine kinase 1
caspase-4 1
prolyl hydroxylase 1
pyruvate dehydrogenase 1
PRE 1
furin 1
RNase 1
dipeptidyl peptidase IV 1
factor C 1
Alternating 1
endonuclease 1
prolyl 3-hydroxylase 1
PNGase F 1
SPC 1
peroxiredoxin 1
neutral sphingomyelinase 1
neuropsin 1
N-acetylglucosaminyltransferase III 1
exoribonuclease 1
glyceraldehyde-3-phosphate dehydrogenase 1
more...
Compound
Clin 501
Dec 450
MEK 324
DNA 304
DIC 122
oxygen 64
tyrosine 54
TNF 44
Interleukin-2 38
Temozolomide 33
serine 30
ATP 28
sulfate 28
calcium 28
BCNU 27
GD3 26
His 26
arginine 25
MTT 25
acetate 24
PEG 24
glucose 24
retinoic acid 23
methionine 23
lysine 19
nitric oxide 17
DDP 17
iodine 17
boron 16
water 16
leucine 16
galactose 16
threonine 16
glutamate 15
BCG 15
creatinine 15
PEG 15
sodium 14
Phe 14
phosphate 13
cAMP 13
hydrogen 13
Asp 13
valine 12
cysteine 12
Melanin 12
zinc 11
fluorine 11
nitrogen 11
cobalt 10
BLM 10
copper 10
iron 10
MAP 10
Gly 10
Optimal 9
glutamine 8
alanine 8
GSH 8
MIA 8
ethanol 8
CAM 8
acetic acid 8
MDA 8
bromide 8
GSH 8
Cardiol 7
neopterin 7
SDS 7
GM3 7
ASA 7
vitamin D 7
Pac 7
ATF 7
GM2 6
Thyroid 6
Tamoxifen 6
tryptophan 6
ACS 6
NOXA 6
Tamoxifen 6
TNM 6
CO2 6
TPA 6
TPA 6
silver 6
formaldehyde 6
Paclitaxel 6
TAP 6
Insulin 6
AMP 6
ACS 6
hyaluronic acid 6
A 42 5
GlcNAc 5
ABL 5
ADP-ribose 5
L-DOPA 5
pyridine 5
urea 5
CBDCA 5
GTP 5
glutamic acid 5
Collagen 5
nicotinamide 5
CBDCA 5
Heparan sulfate 4
NKT 4
NAD 4
DBA 4
PDT 4
TOF 4
alpha-MSH 4
Neo 4
Lactate 4
glycerol 4
NAD 4
MTS 4
carbonate 4
N-acetylcysteine 4
nitrate 4
GMP 4
Celecoxib 4
Neu5Ac 3
CAT 3
DBA 3
Ile 3
Histone 3
TAA 3
THP 3
PMA 3
CCNU 3
barium 3
tryptophan 3
Pyrimethamine 3
chromium 3
NH2 3
benzamide 3
tryptophan 3
potassium 3
nickel 3
Serine 3
ASC 3
DBA 3
COS 3
tryptophan 3
BMC 3
BCR 3
asparagine 3
1,4,7,10-tetraazacyclododecane 3
THP 3
Rose Bengal 3
methanol 3
6-12 3
CAT 3
OPE 3
SSM 3
CAT 3
ADP 3
acetonitrile 3
more...