Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0278883 (
metastatic melanoma
)
6,224
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cutaneous malignant melanoma is the fastest increasing malignancy in humans.
Hepatoma-derived growth factor
(
HDGF
) is a novel growth factor identified from human hepatoma cell line.
HDGF
overexpression is correlated with poor prognosis in various types of cancer including melanoma. However, the underlying mechanism of
HDGF
overexpression in developing melanoma remains unclear. In this study, human melanoma cell lines (A375, A2058, MEL-RM and MM200) showed higher levels of
HDGF
gene expression, whereas human epidermal melanocytes (HEMn) expressed less. Exogenous application of
HDGF
stimulated colony formation and invasion of human melanoma cells. Moreover,
HDGF
overexpression stimulated the degree of invasion and colony formation of B16-F10 melanoma cells whereas
HDGF
knockdown exerted opposite effects in vitro. To evaluate the effects of
HDGF
on tumour growth and metastasis in vivo, syngeneic mouse melanoma and
metastatic melanoma
models were performed by manipulating the gene expression of
HDGF
in melanoma cells. It was found that mice injected with
HDGF
-overexpressing melanoma cells had greater tumour growth and higher metastatic capability. In contrast, mice implanted with
HDGF
-depleted melanoma cells exhibited reduced tumor burden and lung metastasis. Histological analysis of excised tumors revealed higher degree of cell proliferation and neovascularization in
HDGF
-overexpressing melanoma. The present study provides evidence that
HDGF
promotes tumor progression of melanoma and targeting
HDGF
may constitute a novel strategy for the treatment of melanoma.
...
PMID:Up-regulation of hepatoma-derived growth factor facilitates tumor progression in malignant melanoma [corrected]. 2353 73
