Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0278883 (
metastatic melanoma
)
6,224
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Diphenylcyclopropenone
(
DCP
) is a topically administered agent used for more than three decades for treatment of alopecia areata (AA). Moreover, numerous recent studies show it's efficiency in treatment of cutaneous
metastatic melanoma
. Despite being a potentially useful drug still very little is known about the pharmacokinetics of
DCP
. The authors investigated the stability of
DCP
solutions in propylene glycol with the addi- tion of 0.9% aquous solution of natrium chloride (0.9% NaCI) or with water.
DCP
was prepared in two concentrations: 0.1% and 3%. It's stability was then measured with different proportions of 0.9% NaCI or water added and in different temperatures. Contrary to common opinion that
DCP
solutions are extremely unstable, authors have found them to be relatively stable.
DCP
solutions with the addition of equal quantity of 0.9% NaCl decomposed slowly at the temperature of 37C but after 70 h all solutions still contained more than 80% of initial
DCP
. Solutions of
DCP
with the addition of 1% of water at the temperature of 4'C are in the present study stable, containing more than 98% of initial
DCP
after 20 days. Authors discuss the results in spite of possible metabolism of
DCP
on the surface of human skin during topical immunotherapy.
...
PMID:STUDIES ON STABILITY OF 2,3-DIPHENYLCYCLOPROPENONE IN CONTACT WITH WATER AND AQUEOUS NaCI SOLUTIONS. CONCLUSIONS FOR PURPOSE OF TOPICAL THERAPY OF PATIENTS WITH ALOPECIA AREATA. 2963 98
