Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0278883 (
metastatic melanoma
)
6,224
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Metastatic melanoma
accounts for the majority of skin cancer deaths due to its aggressiveness and high resistance to current therapies.
M-phase phosphoprotein 8
(
MPP8
) has been shown to bind to methylated H3K9 and promote tumor cell motility and invasion. The current study aimed to investigate the role of
MPP8
in melanoma growth and metastasis. Our results showed that MMP8 was up-regulated in the
metastatic melanoma
specimens. Knockdown of
MPP8
inhibited melanoma cell growth both
in vitro
and
in vivo
. Furthermore, down-regulation of
MPP8
induced S-phase cell cycle arrest as well as altered expression of cell cycle-related proteins in melanoma cells. In addition, repression of
MPP8
inhibited the migration and invasion of melanoma cells both
in vitro
and
in vivo
. Taken together, these data suggest that
MPP8
knockdown could inhibit the growth and metastasis of melanoma cells and provide novel therapeutic target for melanoma treatment.
...
PMID:Repression of M-phase phosphoprotein 8 inhibits melanoma growth and metastasis
in vitro
and
in vivo
. 3196 65
