Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UMLS:C0278488 (metastatic breast cancer)
7,812 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein HER2 1013 epidermal growth factor receptor 535 estrogen receptor 503 Sep 455 hormone receptor 391 aromatase 356 Mol 277 tyrosine kinase 167 progesterone receptor 166 She 143 neu 139 mTOR 124 CDK4 105 vascular endothelial growth factor 99 DM1 95 albumin 94 PI3K 89 granulocyte colony-stimulating factor 86 erbB-2 79 E-cadherin 75 cytokine 74 EGFR 71 p53 70 nodal 68 AKT 64 epidermal growth factor 63 PARP 63 VEGF 63 PIK3CA 62 ESR1 58 collagen 55 CEA 54 BRCA1 54 carcinoembryonic antigen 53 granulocyte 51 G-CSF 50 oestrogen receptor 50 Aromatase 45 CD44 45 CD8 44 Bcl-2 42 FDG 41 CA15 40 MRI 40 cage 39 IL-6 38 San 38 matrix metalloproteinase 38 PTEN 37 EGF receptor 37 interferon 37 cytokeratin 36 MMP-9 35 catenin 35 prolactin 34 P-glycoprotein 34 receptor tyrosine kinase 33 fibronectin 33 CXCR4 33 caspase-3 33 alkaline phosphatase 32 glycoprotein 32 vimentin 32 MAPK 32 ERBB2 30 Ki-67 30 chemokine 29 ATP 29 cyclin-dependent kinase 27 mucin 27 serum albumin 27 ERK 27 CSF 26 STAT3 26 tyrosine kinase receptor 26 cyclin-dependent kinase 4 26 CD4 25 ACS 25 ERK1 25 Rho 25 more...

Disease metastatic breast cancer 7812 breast cancer 4590 cancer 3299 tumor 2351 metastases 1588 neutropenia 470 carcinoma 449 primary tumor 294 tumor growth 245 MCF 224 tumor progression 218 bone metastases 206 thrombocytopenia 181 myelosuppression 169 leukopenia 139 brain metastases 132 ovarian cancer 104 lung metastases 102 anemia 101 prostate cancer 97 DM1 95 lung cancer 93 liver metastases 92 tumorigenesis 91 stomatitis 89 congestive heart failure 84 peripheral neuropathy 80 hand-foot syndrome 77 adenocarcinoma 71 colorectal cancer 69 ductal carcinoma 68 rash 67 mammary tumor 65 melanoma 65 measurable disease 63 non-small cell lung cancer 62 multiple myeloma 58 neuropathy 58 hypercalcemia 55 recurrent breast cancer 55 carcinogenesis 52 hypertension 49 carcinoma of the breast 49 leukemia 47 bone disease 46 osteoporosis 40 agranulocytosis 40 aggressiveness 39 depression 38 heart failure 38 inflammatory breast cancer 35 carcinomatosis 33 colon cancer 32 sepsis 31 lymphoma 31 sepsis 30 residual disease 30 ductal carcinoma in situ 30 pneumonia 29 carcinoma of the breast 29 solid tumor 28 endometrial cancer 28 systemic disease 27 sensory neuropathy 26 sarcoma 26 tumor angiogenesis 25 Hodgkin's disease 25 diabetes 24 pancreatic cancer 24 hepatocellular carcinoma 24 evaluable disease 23 renal cell carcinoma 23 gastric cancer 23 proteinuria 21 non-Hodgkin's lymphoma 21 SCID 20 EMT 20 spinal cord compression 19 epithelial ovarian cancer 19 CTX 18 more...

Symptom diarrhea 190 nausea 171 pain 170 fatigue 140 vomiting 132 nausea and vomiting 88 asthenia 49 bone pain 47 dyspnea 39 headache 35 myalgia 33 weakness 24 constipation 24 anorexia 24 chills 21 hot flashes 20 arthralgia 20 paresthesia 19 erythema 15 discomfort 15 discomfort 14 abdominal pain 14 hot flushes 13 back pain 13 cachexia 12 dizziness 11 lethargy 11 Ill 10 starvation 8 analgesia 8 sleepiness 7 cough 7 anesthesia 7 flushing 6 seizures 6 chest pain 5 cancer pain 5 polyuria 5 insomnia 5 menopausal symptoms 5 ataxia 5 persistent cough 4 abdominal discomfort 4 overweight 4 hemoptysis 4 Cushingoid 3 thinning 3 lightheadedness 3 physical symptom 3 low back pain 3 paraparesis 3 shoulder pain 3 Scratch 3 night sweats 3 Depressive symptoms 3 shortness of breath 3 exertional dyspnea 3 epigastric pain 3 blurred vision 3 tonic-clonic seizure 3 acidity 3 neck pain 2 polydipsia 2 exhaustion 2 groin pain 2 decreased appetite 2 hip pain 2 stomach pain 2 tenesmus 2 splenomegaly 2 respiratory distress 2 angina 2 fever of unknown origin 2 bitter taste 2 Flu-like symptoms 2 tachypnea 2 muscle cramps 2 HSA 2 myoclonus 2 masculinization 2 more...

Drug Herceptin 395 Taxol 149 Docetaxel 145 DM1 96 Adriamycin 82 Bevacizumab 74 Taxotere 74 Vinorelbine 59 Fulvestrant 57 G-CSF 54 CTX 52 CSF 46 Ixabepilone 45 Xeloda 35 MAP 33 Pertuzumab 32 CTX 28 GEO 26 Navelbine 24 Everolimus 24 Gemzar 22 CTC 21 CTC 21 Dermatol 18 CTX 18 Zoledronic acid 17 ICI 16 lysine 16 ADM 16 Arimidex 16 IL-2 14 Filgrastim 13 Zoledronic acid 13 Tykerb 12 Filgrastim 12 Cremophor EL 11 Femara 10 EE2 10 CPT-11 10 Pemetrexed 10 Zoladex 9 ABC 9 IFN-gamma 9 ROC 9 Etoposide 8 Monit 7 TAC 7 Albumin 7 Novantrone 7 uPA 7 Spiegel 7 ROS 7 Alliance 7 Gefitinib 7 Leucovorin 6 Cetuximab 6 Epidoxorubicin 6 Zoladex 6 TAT 6 vitamin E 6 Dexrazoxane 5 Bortezomib 5 Imatinib 5 ADR 5 Alimta 5 Idarubicin 4 NADH 4 Gleevec 4 IL-11 4 ETS 4 Pirarubicin 4 NVP 4 VCR 4 Bayer 4 CAM 4 Sorafenib 4 Denosumab 4 Aromasin 4 Insulin detemir 4 Dasatinib 3 more...

Enzyme ERK 1030 focal adhesion kinase 86 mitogen-activated protein kinase 71 PARP 65 protein kinase 55 P-glycoprotein 34 alkaline phosphatase 32 urokinase-type plasminogen activator 29 luciferase 28 caspase-3 28 ACS 25 cdc2 22 thymidine phosphorylase 20 alanine aminotransferase 20 lactate dehydrogenase 18 reverse transcriptase 18 aspartate aminotransferase 18 MEK 16 topoisomerase 15 phosphatidylinositol 3-kinase 15 topoisomerase 15 phosphoinositide 3-kinase 14 proteasome 14 thymidylate synthase 12 dihydropyrimidine dehydrogenase 12 CYP3A4 11 dihydropyrimidine dehydrogenase 10 ATPase 10 lysyl oxidase 9 MDR 9 protein kinase C 9 AST 8 cathepsin D 8 MMP 8 GSK 7 dihydrofolate reductase 7 caspase-1 7 collagenase 7 MTD 6 caspase-9 6 TAT 6 hyaluronidase 6 hyaluronidase 6 catalase 6 RNA polymerase 6 peroxidase 6 creatine kinase 6 plasmin 6 TOR 6 trypsin 5 indoleamine 2,3-dioxygenase 5 sulfatase 5 thymidine kinase 5 cathepsin B 5 DHAD 5 caspase-8 5 MIP 5 prostate-specific antigen 5 MAP 5 gamma-glutamyl transpeptidase 5 APC 5 ALDH 5 cathepsin K 4 RNase 4 aldehyde dehydrogenase 4 matrix metalloproteinase 9 4 prostate-specific membrane antigen 4 neuraminidase 3 sialyltransferase 3 DNase 3 RNase 3 thrombin 3 farnesyltransferase 3 phosphatidylinositol-4,5-bisphosphate 3-kinase 3 phospholipase D 3 DNA polymerase 3 transcriptase 3 phospholipase C 3 CEP 3 acid phosphatase 3 more...

Compound Clin 841 Dec 556 MDA 516 DNA 295 acetate 130 Adriamycin 116 Paclitaxel 113 Tamoxifen 108 Tamoxifen 102 Docetaxel 97 Capecitabine 96 5-FU 74 calcium 58 tyrosine 55 Gemcitabine 54 Gemcitabine 54 CTX 52 ADR 46 glucose 45 oxygen 42 PEG 36 water 36 CAM 33 MTT 32 Estrogen 30 Estrogen 29 ATP 29 CAP 29 folinic acid 27 Mitoxantrone 26 MBC 26 MBC 26 sulfate 25 ACS 25 ACS 25 Epirubicin 25 sodium 23 Mitoxantrone 23 Progesterone 23 MAP 22 TNF 22 phosphate 21 methionine 21 lysine 20 creatinine 20 VP-16 20 Anastrozole 20 hyaluronic acid 20 PEG 19 DDP 19 Luminal 18 Exemestane 18 iron 18 Aminoglutethimide 18 MMC 17 ICI 16 Letrozole 16 Methotrexate 16 galactose 16 Pac 15 CBDCA 15 serine 15 MTS 15 CBDCA 15 ACTH 15 TTP 14 iodine 13 Optimal 13 ASA 13 pyrimidine 12 formaldehyde 12 pyrimidine 12 nitrogen 12 cysteine 12 MPA 11 potassium 11 ADP-ribose 11 zinc 11 ethanol 11 arginine 11 more...

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