Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278488 (metastatic breast cancer)
 7,812 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
HER2 1013
epidermal growth factor receptor 535
estrogen receptor 503
Sep 455
hormone receptor 391
aromatase 356
Mol 277
tyrosine kinase 167
progesterone receptor 166
She 143
neu 139
mTOR 124
CDK4 105
vascular endothelial growth factor 99
DM1 95
albumin 94
PI3K 89
granulocyte colony-stimulating factor 86
erbB-2 79
E-cadherin 75
cytokine 74
EGFR 71
p53 70
nodal 68
AKT 64
VEGF 63
epidermal growth factor 63
PARP 63
PIK3CA 62
ESR1 58
collagen 55
CEA 54
BRCA1 54
carcinoembryonic antigen 53
granulocyte 51
oestrogen receptor 50
G-CSF 50
CD44 45
Aromatase 45
CD8 44
Bcl-2 42
FDG 41
CA15 40
MRI 40
cage 39
San 38
matrix metalloproteinase 38
IL-6 38
PTEN 37
interferon 37
EGF receptor 37
cytokeratin 36
MMP-9 35
catenin 35
P-glycoprotein 34
prolactin 34
caspase-3 33
CXCR4 33
receptor tyrosine kinase 33
fibronectin 33
MAPK 32
alkaline phosphatase 32
glycoprotein 32
vimentin 32
ERBB2 30
Ki-67 30
chemokine 29
ATP 29
mucin 27
cyclin-dependent kinase 27
ERK 27
serum albumin 27
CSF 26
cyclin-dependent kinase 4 26
STAT3 26
tyrosine kinase receptor 26
FAC 25
ACS 25
CAF 25
Rho 25
ERK1 25
CD4 25
cyclin 24
mucin 1 24
focal adhesion kinase 24
GM-CSF 24
EGF 24
CXCL12 23
Estrogen receptor 23
BRCA2 23
LHRH 23
MMP-2 22
histone 22
tumor necrosis factor 22
TNF 22
metastasis suppressor 22
CD34 22
insulin-like growth factor 21
urokinase-type plasminogen activator 21
hemoglobin 21
p38 21
EMT 20
thymidine phosphorylase 20
cyclin D1 20
non-Hodgkin's lymphoma 20
cyclooxygenase-2 20
insulin 20
cytokeratin 19 20
histone deacetylase 20
poly(ADP-ribose) polymerase 19
CD45 19
proto-oncogene 18
FISH 18
interleukin-2 18
mammaglobin 18
MUC1 18
CTX 18
endoplasmic reticulum 18
androgen receptor 18
Cyclin 18
interleukin-6 17
CD24 17
polypeptide 17
PEG 17
epithelial cell adhesion molecule 16
RANKL 16
lactate dehydrogenase 16
IL-8 16
IFN 16
PD-L1 15
ACTH 15
N-cadherin 15
MMP9 15
growth hormone 15
phosphatidylinositol 3-kinase 15
c-Jun 14
FAK 14
phosphoinositide 3-kinase 14
VEGFR2 14
IL-2 14
macrophage colony-stimulating factor 14
HER3 14
osteopontin 14
TTP 14
proteasome 14
HLA 14
granulocyte-macrophage colony-stimulating factor 13
ZEB1 13
bcl-2 13
FSH 13
AKT1 13
C30 13
Cyclin-dependent kinase 13
TGF-beta 13
alanine aminotransferase 13
lectin 12
parathyroid hormone-related protein 12
HDC 12
EP4 12
PD-1 12
more...
Disease
metastatic breast cancer 7812
breast cancer 4590
cancer 3299
tumor 2351
metastases 1588
neutropenia 470
carcinoma 449
primary tumor 294
tumor growth 245
MCF 224
tumor progression 218
bone metastases 206
thrombocytopenia 181
myelosuppression 169
leukopenia 139
brain metastases 132
ovarian cancer 104
lung metastases 102
anemia 101
prostate cancer 97
DM1 95
lung cancer 93
liver metastases 92
tumorigenesis 91
stomatitis 89
congestive heart failure 84
peripheral neuropathy 80
hand-foot syndrome 77
adenocarcinoma 71
colorectal cancer 69
ductal carcinoma 68
rash 67
mammary tumor 65
melanoma 65
measurable disease 63
non-small cell lung cancer 62
multiple myeloma 58
neuropathy 58
hypercalcemia 55
recurrent breast cancer 55
carcinogenesis 52
hypertension 49
carcinoma of the breast 49
leukemia 47
bone disease 46
osteoporosis 40
agranulocytosis 40
aggressiveness 39
depression 38
heart failure 38
inflammatory breast cancer 35
carcinomatosis 33
colon cancer 32
lymphoma 31
sepsis 31
ductal carcinoma in situ 30
sepsis 30
residual disease 30
carcinoma of the breast 29
pneumonia 29
solid tumor 28
endometrial cancer 28
systemic disease 27
sensory neuropathy 26
sarcoma 26
tumor angiogenesis 25
Hodgkin's disease 25
hepatocellular carcinoma 24
diabetes 24
pancreatic cancer 24
gastric cancer 23
renal cell carcinoma 23
evaluable disease 23
non-Hodgkin's lymphoma 21
proteinuria 21
SCID 20
EMT 20
spinal cord compression 19
epithelial ovarian cancer 19
CTX 18
Luminal 18
cardiomyopathy 18
lymphadenopathy 17
glioblastoma 17
infiltrating ductal carcinoma 17
Febrile neutropenia 16
hyperglycemia 16
minimal residual disease 16
squamous cell carcinoma 16
Leukemia 16
TTP 15
cold 15
head and neck cancer 15
TTP 15
hypercalcemia of malignancy 14
phlebitis 14
cervical cancer 14
renal failure 14
CNS metastases 13
lymphopenia 13
pulmonary embolism 13
hematologic malignancies 12
aggression 12
pancytopenia 12
rheumatoid arthritis 12
influenza 12
skin metastases 12
graft-versus-host disease 12
dysphagia 11
dermatitis 11
uterus 11
herpes simplex 11
bladder cancer 11
bowel obstruction 11
metastatic melanoma 11
lobular breast carcinoma 11
acute myeloid leukemia 11
Blocking 10
amenorrhea 10
cancer recurrence 10
interstitial pneumonia 10
B-cell lymphoma 10
infectious diseases 10
tumor vasculature 10
brain tumor 10
diplopia 10
small cell lung cancer 9
cytomegalovirus 9
West 9
malignant pleural effusion 9
metastatic gastric cancer 9
hyperprolactinemia 9
invasive cancer 9
Hand-foot syndrome 9
PDB 9
Best 9
obesity 9
Breast carcinoma 8
deep vein thrombosis 8
renal cancer 8
lung carcinoma 8
adenoma 8
confusion 8
retinoblastoma 8
emotional distress 8
cardiovascular disease 8
NOD 8
immunodeficiency 8
liver disease 8
pathological fracture 8
hemolytic anemia 7
uterine cancer 7
skin cancer 7
acute leukemia 7
EMA 7
acute lymphoblastic leukemia 7
epithelial tumor 7
HIV 7
meningioma 7
suicide 7
more...
Symptom
diarrhea 190
nausea 171
pain 170
fatigue 140
vomiting 132
nausea and vomiting 88
asthenia 49
bone pain 47
dyspnea 39
headache 35
myalgia 33
constipation 24
anorexia 24
weakness 24
chills 21
arthralgia 20
hot flashes 20
paresthesia 19
erythema 15
discomfort 15
discomfort 14
abdominal pain 14
hot flushes 13
back pain 13
cachexia 12
dizziness 11
lethargy 11
Ill 10
analgesia 8
starvation 8
cough 7
sleepiness 7
anesthesia 7
seizures 6
flushing 6
chest pain 5
menopausal symptoms 5
insomnia 5
polyuria 5
cancer pain 5
ataxia 5
persistent cough 4
hemoptysis 4
abdominal discomfort 4
overweight 4
Cushingoid 3
thinning 3
lightheadedness 3
paraparesis 3
night sweats 3
Depressive symptoms 3
Scratch 3
exertional dyspnea 3
shortness of breath 3
blurred vision 3
tonic-clonic seizure 3
acidity 3
shoulder pain 3
physical symptom 3
low back pain 3
epigastric pain 3
neck pain 2
polydipsia 2
exhaustion 2
groin pain 2
stomach pain 2
tenesmus 2
splenomegaly 2
angina 2
bitter taste 2
fever of unknown origin 2
respiratory distress 2
tachypnea 2
Flu-like symptoms 2
hip pain 2
HSA 2
muscle cramps 2
decreased appetite 2
myoclonus 2
masculinization 2
inanition 1
acute pain 1
vaginal pain 1
ophthalmoplegia 1
acute abdomen 1
muscle stiffness 1
rib pain 1
agitation 1
rigors 1
photopsia 1
anal pain 1
thigh pain 1
Sister Mary Joseph's nodule 1
No adverse effect 1
spasm 1
clubbing 1
excessive sweating 1
dysarthria 1
stridor 1
dysuria 1
asterixis 1
acute stress 1
right upper quadrant pain 1
numbness 1
axillary pain 1
pallor 1
Cushingoid 1
metamorphopsia 1
testicular pain 1
memory loss 1
tinnitus 1
dental pain 1
pelvic pain 1
collapse 1
periorbital edema 1
heartburn 1
tremor 1
arm weakness 1
Murphy's sign 1
hepatomegaly 1
chest tightness 1
sore throat 1
hoarseness 1
Neuropathic pain 1
acute abdominal pain 1
Flare 1
Negative myoclonus 1
dry skin 1
peau d'orange 1
Drug
Herceptin 395
Taxol 149
Docetaxel 145
DM1 96
Adriamycin 82
Taxotere 74
Bevacizumab 74
Vinorelbine 59
Fulvestrant 57
G-CSF 54
CTX 52
CSF 46
Ixabepilone 45
Xeloda 35
MAP 33
Pertuzumab 32
CTX 28
GEO 26
Everolimus 24
Navelbine 24
Gemzar 22
CTC 21
CTC 21
Dermatol 18
CTX 18
Zoledronic acid 17
ICI 16
lysine 16
ADM 16
Arimidex 16
IL-2 14
Zoledronic acid 13
Filgrastim 13
Tykerb 12
Filgrastim 12
Cremophor EL 11
Femara 10
CPT-11 10
Pemetrexed 10
EE2 10
Zoladex 9
ROC 9
IFN-gamma 9
ABC 9
Etoposide 8
TAC 7
Monit 7
Albumin 7
Alliance 7
Novantrone 7
ROS 7
Spiegel 7
uPA 7
Gefitinib 7
Leucovorin 6
TAT 6
Zoladex 6
Epidoxorubicin 6
Cetuximab 6
vitamin E 6
Imatinib 5
ADR 5
Alimta 5
Dexrazoxane 5
Bortezomib 5
Sorafenib 4
NVP 4
Idarubicin 4
NADH 4
Bayer 4
Aromasin 4
ETS 4
CAM 4
VCR 4
Pirarubicin 4
Denosumab 4
Gleevec 4
IL-11 4
Insulin detemir 4
2-Methoxyestradiol 3
Fareston 3
Dasatinib 3
Ibandronate 3
Erlotinib 3
Mutagen 3
TTC 3
EPI 3
Hypaque 3
Estrogens 3
Tarceva 3
Gel 3
VCR 3
Vitamin E 3
PTH 3
CDX 3
Hypaque 3
Fareston 3
CDX 3
Irinotecan 2
Verteporfin 2
Lupron 2
TAK 2
Leaf 2
Glutethimide 2
Bifidobacterium 2
Luteinizing 2
Idoxifene 2
Xanthium 2
nitroglycerin 2
Vandetanib 2
Cardiovasc 2
Vindesine 2
Vindesine 2
Paraplatin 2
Emodin 2
Ambisome 2
Oxaliplatin 2
Indomethacin 2
Tipifarnib 2
Amifostine 2
IFN-beta 2
Raloxifene 2
Paraffin 2
Norplant 2
Emodin 2
Fragment 2
Epoetin 2
Edatrexate 2
Trabectedin 2
CDP 1
NH3 1
Gestrinone 1
lactose 1
R1881 1
Doxycycline 1
Axitinib 1
Acyclovir 1
Trilostane 1
ACT 1
Depo-Provera 1
AraC 1
Portal 1
CCL 1
Podophyllum 1
BH4 1
Sunitinib malate 1
Velban 1
Check 1
Activin 1
Triad 1
Heme 1
Fludarabine 1
balanced salt solution 1
Vicryl 1
Fluorescein 1
Biopolymers 1
DMAP 1
Diurnal 1
DNase I 1
DHT 1
more...
Enzyme
ERK 1030
focal adhesion kinase 86
mitogen-activated protein kinase 71
PARP 65
protein kinase 55
P-glycoprotein 34
alkaline phosphatase 32
urokinase-type plasminogen activator 29
luciferase 28
caspase-3 28
ACS 25
cdc2 22
alanine aminotransferase 20
thymidine phosphorylase 20
reverse transcriptase 18
aspartate aminotransferase 18
lactate dehydrogenase 18
MEK 16
topoisomerase 15
topoisomerase 15
phosphatidylinositol 3-kinase 15
phosphoinositide 3-kinase 14
proteasome 14
dihydropyrimidine dehydrogenase 12
thymidylate synthase 12
CYP3A4 11
ATPase 10
dihydropyrimidine dehydrogenase 10
protein kinase C 9
MDR 9
lysyl oxidase 9
MMP 8
cathepsin D 8
AST 8
caspase-1 7
dihydrofolate reductase 7
collagenase 7
GSK 7
hyaluronidase 6
RNA polymerase 6
hyaluronidase 6
plasmin 6
catalase 6
creatine kinase 6
peroxidase 6
TOR 6
caspase-9 6
TAT 6
MTD 6
indoleamine 2,3-dioxygenase 5
caspase-8 5
thymidine kinase 5
MIP 5
APC 5
MAP 5
prostate-specific antigen 5
gamma-glutamyl transpeptidase 5
DHAD 5
trypsin 5
sulfatase 5
ALDH 5
cathepsin B 5
cathepsin K 4
RNase 4
matrix metalloproteinase 9 4
aldehyde dehydrogenase 4
prostate-specific membrane antigen 4
sialyltransferase 3
DNase 3
sialyltransferase 3
farnesyltransferase 3
RNase 3
thrombin 3
transcriptase 3
sialyltransferase 3
DNA polymerase 3
phosphatidylinositol-4,5-bisphosphate 3-kinase 3
aldehyde dehydrogenase 3
aldehyde dehydrogenase 3
farnesyltransferase 3
STK11 3
glyceraldehyde-3-phosphate dehydrogenase 3
CEP 3
acid phosphatase 3
transglutaminase 3
MMP-3 3
phosphodiesterase 3
CEP 3
phospholipase C 3
phospholipase D 3
neuraminidase 3
thyroid peroxidase 3
aldehyde dehydrogenase 3
IKK 3
aldehyde dehydrogenase 3
matrix metalloproteinase 2 3
MDP 3
cathepsin L 2
GRK5 2
PDK1 2
thromboplastin 2
CPT 2
AMPK 2
m-calpain 2
NOS 2
firefly luciferase 2
AMP-activated protein kinase 2
caspase-7 2
phosphoglucose isomerase 2
DCF 2
deoxycytidine kinase 2
phospholipase A2 2
lipase 2
15-hydroxyprostaglandin dehydrogenase 2
granzyme B 2
arginase 2
ornithine decarboxylase 2
enolase 2
cathepsin G 2
carboxylesterase 2
glucose-6-phosphate dehydrogenase 2
PDE 2
kinesin 2
cytosine deaminase 2
adenylate cyclase 2
SNO 2
AMPK 2
CPT 2
caspase-7 2
arylsulfatase 2
demethylase 2
CPT 2
neutrophil elastase 2
ribonuclease 1
TdT 1
NO synthase 1
cathepsin S 1
conjugase 1
CaMKII 1
legumain 1
monoamine oxidase 1
diamine oxidase 1
MDH 1
peroxiredoxin 1
TRS 1
CDR 1
CAO 1
triphosphatase 1
phosphatidylinositol 4-kinase 1
5'-nucleotidase 1
MSAS 1
dihydropteroate synthase 1
ribonuclease 1
glutathione S-transferase 1
protein phosphatase 2A 1
glutaminase 1
apyrase 1
subtilisin 1
ubiquitin-protein ligase 1
proteinase K 1
more...
Compound
Clin 841
Dec 556
MDA 516
DNA 295
acetate 130
Adriamycin 116
Paclitaxel 113
Tamoxifen 108
Tamoxifen 102
Docetaxel 97
Capecitabine 96
5-FU 74
calcium 58
tyrosine 55
Gemcitabine 54
Gemcitabine 54
CTX 52
ADR 46
glucose 45
oxygen 42
PEG 36
water 36
CAM 33
MTT 32
Estrogen 30
ATP 29
Estrogen 29
CAP 29
folinic acid 27
MBC 26
MBC 26
Mitoxantrone 26
Epirubicin 25
ACS 25
ACS 25
sulfate 25
Mitoxantrone 23
sodium 23
Progesterone 23
MAP 22
TNF 22
methionine 21
phosphate 21
creatinine 20
VP-16 20
lysine 20
hyaluronic acid 20
Anastrozole 20
DDP 19
PEG 19
Aminoglutethimide 18
Exemestane 18
iron 18
Luminal 18
MMC 17
ICI 16
galactose 16
Methotrexate 16
Letrozole 16
Pac 15
CBDCA 15
ACTH 15
serine 15
MTS 15
CBDCA 15
TTP 14
iodine 13
ASA 13
Optimal 13
pyrimidine 12
pyrimidine 12
cysteine 12
nitrogen 12
formaldehyde 12
arginine 11
ethanol 11
zinc 11
MPA 11
MPA 11
ADP-ribose 11
potassium 11
MPA 11
aldosterone 11
Ifosfamide 10
CPT-11 10
fluorine 10
MEK 10
BCG 10
threonine 9
MDR 9
nitric oxide 9
GalNAc 9
vitamin D 8
Toremifene 8
Vimentin 8
retinoic acid 8
BCNU 8
DMAP 8
DFS 7
NAD 7
anthracene 7
MTX 7
boron 7
Asp 7
glutamine 7
Wellcome 7
salt 7
ADP 7
hydrogen 7
TEM 7
Estradiol 7
TPA 7
cAMP 7
His 6
PGE 6
Cardiol 6
TBI 6
TRH 6
glutamate 6
bromide 6
TSH 6
TPA 6
Hematoxylin 6
leucine 5
Tegafur 5
Topotecan 5
THP 5
NAD 5
tryptophan 5
5-formyltetrahydrofolate 5
TNM 5
proline 5
Resveratrol 5
TOF 5
ADP 5
AMP 5
A 71 5
DTPA 5
silicon 5
Gly 5
THP 5
alanine 5
NH2 5
ammonium 5
acetonitrile 5
Vinblastine 5
ADP 5
Curcumin 5
PMA 4
GMP 4
Melatonin 4
Triton X-100 4
DDC 4
ICRF-187 4
Norton 4
Phe 4
cobalt 4
Vitamin E 4
strontium 4
dUTP 4
more...