Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278488 (metastatic breast cancer)
 7,812 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Until 1971 13 cases of breast cancer in men were observed in our service. In the world literature it accounts for 1% of all cancer of the breast; in our series we have found 4% of all breast cancer. Men present themselves for treatment later and with more advanced local signs than women. In our series, the greatest number of cases occurs near the seventies in men, which is about twenty years later than in women. The etiology is remained unknown, but Klinefelter's disease seems to be a risk for breast cancer. If there are no metastasis, we prefer in our service the surgical treatment as unique treatment. If possible the operation of Patey is realised, but sometimes we have to do a simple mastectomy only as a safe alternative for poor risk patient. In case of metastatic breast cancer the adjuvant treatment was X-ray therapy, chemotherapy and in some of our cases hormonotherapy. We do not have any experience with suppressive hormonal therapy such as orchiectomy or adrenalectomy. Most of the authors think that prognosis of breast cancer in males is worse than in women; the constant central localization of the tumour may be an explanation for that. The fate of women with central lesions is as poor as in males.
 ...
PMID:[Breast cancer in males]. 46 63

Male breast cancer is a rare disease. Symptoms and signs resemble breast cancer in women: A palpable mass, enlarged lymph nodes or skin changes (ulceration, secretion, peau d'orange) mandate mammography, ultrasound to assess the regional lymph nodes. The definitive diagnosis is made by biopsy. Men with breast cancer are treated along the same principles as women: resection followed by systemic and radiation therapy. Tamoxifen, not aromatase inhibitors, is the adjuvant therapy of choice for estrogen receptor positive tumors. Therapy of men with metastatic breast cancer follows the same principles as therapy of women.
 ...
PMID:[Male Breast Cancer: What is Different?]. 2683 23