Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0278488 (
metastatic breast cancer
)
7,812
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Gene expression profiling has been suggested to predict breast cancer outcome. The prognostic value of the 8q22-24 position in breast cancer remains to be elucidated. The present study evaluated expression patterns of the genes located at this position in metastatic and non-
metastatic breast cancer
. A total of 85 patients with recurrent/metastatic (n=15) and non-metastatic (n=70) early-stage, estrogen receptor-positive and lymph node-negative breast tumors were included. In addition, 15 normal breast tissue samples were used as controls. Demographic and clinical features were recorded. Subsequently, mRNA copy numbers of
exostosin
glycosyltransferase 1 (
EXT1
), WNT1 inducible signaling pathway protein 1 (
WISP1
), ATPase family, AAA domain containing 2 (
ATAD2
), TSP-like 5 (
TSPYL5
), metadherin (
MTDH
) and cyclin E2 (
CCNE2
) genes were measured by reverse transcription-quantitative polymerase chain reaction assay. The expression of
EXT1
and
WISP1
exhibited a significant decline in the
metastatic breast cancer
group compared to the control (P=0.015 and P=0.012, respectively). The expression of
TSPYL5
,
MTDH
and
ATAD2
was significantly decreased in the metastatic (P=0.002, P=0.018 and P=0.016, respectively) and non-metastatic (P=0.038, P=0.045 and P=0.000, respectively) breast cancer groups compared with the control. The expression of
CCNE2
in the metastatic and non-
metastatic breast cancer
groups was significantly increased compared with the control (P=0.002 and P=0.001, respectively).
WISP1
expression demonstrated a correlation with patient age and tumor size, and
TSPYL5
expression was correlated with lymphovascular invasion. None of the genes investigated exhibited any correlation with stage and grade of disease. The
TSPYL5
,
MTDH
,
ATAD2
and
CCNE2
genes may be implicated in the pathogenesis of human breast cancer, while the
WISP1
and
EXT1
genes may have the potential to serve as promising indicators of the risk of metastasis. However, further studies are required to validate these results.
...
PMID:Gene expression profiling of the 8q22-24 position in human breast cancer:
TSPYL5
,
MTDH
,
ATAD2
and
CCNE2
genes are implicated in oncogenesis, while
WISP1
and
EXT1
genes may predict a risk of metastasis. 2789 39
