Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0278488 (metastatic breast cancer)
 7,812 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

39 previously treated patients with metastatic breast cancer were treated in a partially randomized study evaluating VP-16 and the combination of Vincristine (VCR) and Adriamycin (ADR). Of the 19 patients treated with VP-16 initially, two had partial remissions. No responses were noted in eleven patients who corssed-over after failing VCR plus ADR. Of the 20 patients treated with VCR plus ADR initially, four patients had partial responses. An additional 2/15 patients responded on crossover after failing initially on VP-16. No significant differences in time to last follow-up or death could be detected between the two treatment programs.
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PMID:Evaluation of VP-16 and the combination of adriamycin and vincristine in advanced breast cancer. 101 48

Vincristine (VCR) and etoposide (VP-16) have been shown to be synergistic in a murine model, and this combination was studied in a phase II trial. Eligibility required measurable disease, a performance status of 0-2, a life expectancy of > or = 2 months, an interval of at least 3 weeks since the receipt of previous radiation therapy or chemotherapy and recovery from related toxicity, no prior treatment with VCR or VP-16, and no more than two prior chemotherapy regimens (only one for treatment of metastatic disease). Treatment consisted of 0.5 mg i.v. (bolus) VCR followed by 200 mg/m2 VP-16 given over 2 h. Both drugs were given daily for 3 consecutive days every 3 weeks (total dose: VCR, 1.5 mg; VP-16, 600 mg/m2). A total of 18 patients with metastatic breast cancer were accured; 14 had adjuvant chemotherapy and 8 had chemotherapy for advanced disease. As judged by International Union Against Cancer (UICC) criteria, one complete response (CR) and three partial responses (PR) were obtained, for a CR + PR rate of 22% (95% confidence interval, 6%-48%). All responders had soft-tissue involvement only. Six patients had stable disease and 8 showed progression. The median time to treatment failure was 3.5 months, and the median survival from study entry was 8.3 months. The major toxicity was myelosuppression, with 9 patients (50%) experiencing a total WBC of < 1,000/mm3. Grade 2-3 neurologic toxicity was noted in 6 patients (33%) and grade 3 nausea and vomiting was noted in 5 (28%). The combination of VCR and VP-16 is active in advanced breast cancer but is not convincingly superior to either of these agents used alone.
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PMID:Vincristine with high-dose etoposide in advanced breast cancer: a phase II trial of the Piedmont Oncology Association. 798 95

We present an elderly patient with metastatic breast cancer and Parkinson's disease (PD) of moderate severity who developed paralytic ileus of protracted course after a low dose of 0.16 mg/m(2) intravenous vincristine. Since colonic myenteric plexus involvement occurs in PD, we suggest that it may predispose to vinca alkaloids-induced autonomic neuropathy. Vincristine should be used with caution in this clinical setup.
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PMID:Vincristine-induced paralytic ileus in Parkinson's disease. 1859 Oct 64