Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0278488 (metastatic breast cancer)
 7,812 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Leuprolide (Lupron, TAP Pharmaceuticals, North Chicago), a gonadotropin-releasing hormone analogue, was administered to 26 premenopausal women with metastatic breast cancer. Of 25 evaluable patients, 11 (44%) had a partial response with a median duration of 39 weeks and five (20%) remained stable. Six patients showed early rapid progression of their disease. Toxicity was mild and included hot flashes, nausea, vomiting, and headache. Leuprolide induced amenorrhea in all patients who received treatment for ten weeks or longer. We conclude that this GnRH analogue provides a safe and effective means of producing medical castration in premenopausal patients with metastatic breast carcinoma.
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PMID:Medical castration produced by the GnRH analogue leuprolide to treat metastatic breast cancer. 392 58

We included 58 premenopausal patients with metastatic breast cancer in an open study with leuprorelin acetate monthly depot. The overall response rate was 15/50 patients (30%). The median duration to tumour progression according to Kaplan-Meier analysis was 12 months. After leuprorelin acetate treatment permanent suppression of ovarian function was recorded with oestradiol levels below 30 pg/ml. The side effects were acceptable. The most common were: menopausal complaints, headache, dizziness and nausea. Changes of laboratory parameters were caused by cessation of ovarian function and progression of the underlying disease. Leuprorelin acetate is an effective drug for first line palliative treatment of premenopausal, metastatic breast cancer. The objective response rate is similar to other GnRH analogues and to reported data on surgical oophorectomy.
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PMID:Clinical efficacy of leuprorelin acetate monthly depot in premenopausal patients with metastatic breast cancer. 2159 Jan 27