Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0278488 (metastatic breast cancer)
 7,812 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 44-year-old premenopausal woman with metastatic breast cancer to the bones was treated with tamoxifen and tegafur followed by a minimal dose of tamoxifen alone, with complete response for more than 90 months. Initially, tamoxifen was given with a dose of 20 mg daily in combination with 600 mg daily of tegafur for 22 months, a remission of low back pain and recalcification of the lytic lesion in the pelvis. After reduction of tamoxifen dose to 10 mg/daily and withdrawal of tegafur, regression of the disease continued for another 68+ months. Bone metastasis completely disappeared, and the patient is still in remission. No significant side effects from tamoxifen were encountered. Tamoxifen appears to be a useful and safe treatment for recurrent breast cancer.
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PMID:[A case of recurrent breast cancer responding to long-term administration of tamoxifen]. 643 1

A 75-year-old woman with low back pain had attended a local orthopedic clinic since around December 1990, but no remission had been achieved. The patient also had a gait disturbance, and visited our hospital for detailed examinations in May 1992. Bone scintigraphy revealed metastatic tumors of L 1 and L 2. Histopathological findings and tumor marker measurements led to a diagnosis of primary breast cancer. The patient was treated with TAM (20 mg/day) and 5-FU (150 mg/day). The tumor marker levels showed repeated cycles of slight increases and decreases. Acute elevations of the tumor markers occurring on January 24, 1997, and January 5, 2001, were successfully treated with MPA (800 mg/day) and 5'-DFUR (600 mg/day), but continuous administration of these drugs was difficult because of their adverse effects. A significant increase in the tumor marker levels (CA15-3 600 U/ml, CEA 197 ng/ml) was again observed on December 2, 2003. The patient showed no favorable response to the combination of MPA and 5'-DFUR but had persistent back pain. Exemestane given at 25 mg/day markedly improved both clinical symptoms and tumor marker levels. The results indicate that exemestane would be an effective hormone therapy for metastatic breast cancer.
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PMID:[Effective reduction of elevated tumor markers by exemestane--a 12-year follow-up of a case of bone metastatic breast cancer]. 1579 20

A 71-year-old woman with a 10-month history of atraumatic low back pain was referred to physical therapy after an insidious exacerbation of symptoms. Red flags raised suspicions for spinal compression fracture, necessitating the physical therapist to contact her physician and recommend imaging. Radiographs and magnetic resonance imaging were ordered, the latter of which showed an acute fracture at T10, with lesions at T9 and in the liver suggesting metastasis. Following bone scintigraphy and an ultrasound-guided biopsy of a liver lesion, she was diagnosed with metastatic breast cancer. J Orthop Sports Phys Ther 2018;48(7):595. doi:10.2519/jospt.2018.7768.
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PMID:Differential Diagnosis of a Pathological Spine Fracture. 3006 19