Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0278488 (
metastatic breast cancer
)
7,812
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It is recommended not to use transdermal fentanyl (Fe) patches (
TFP
) in cancer cachexia but
TFP
may be the only available option for pain. Limited evidence suggests lower Fe absorption from
TFP
in cachexia. We describe a case of
metastatic breast cancer
with refractory cachexia. Her pain was uncontrolled on
TFP
and was route switched and drug rotated to intravenous morphine (M). We were conservative and did not use the 1:100
TFP
to oral M conversion ratio. Assuming opioid needs were similar before and after switch/rotation, the suitable conversion ratio in this case was about 1:25. Absent clear guidelines on converting from
TFP
in cachexia, it is better to avoid
TFP
. When essential to use
TFP
in cachexia, caution should be taken when switching from
TFP
to avoid overdose.
...
PMID:Transdermal fentanyl to parenteral morphine route switch and drug rotation in refractory cancer cachexia. 3149 73
