Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0278488 (metastatic breast cancer)
 7,812 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical and laboratory evidence of a dose-response relationship has prompted the investigation of high-dose therapy with bone marrow transplantation in the treatment of women with metastatic breast cancer. Remission rates are high, but only a small proportion appear durable. An antitumor effect is associated with allogeneic graft-versus-host disease (GVHD) as well as with a similar syndrome that can be induced following autologous transplantation (autologous GVHD) by treatment with cyclosporine A following marrow infusion. The clinical manipulation of autologous GVHD may increase the potency of high-dose therapy. Clinical studies indicate that autologous GVHD can be induced in women with breast cancer and can be augmented by the administration of interferon gamma. Preliminary evidence indicates associated antitumor activity in vitro.
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PMID:Autologous graft-versus-host disease: immunotherapy of breast cancer after bone marrow transplantation. 840 Mar 31

MDA-MB-231, an HLA-A2(+), HER2/neu(+) allogeneic breast cancer cell line genetically modified to express the costimulatory molecule CD80 (B7-1), was used to vaccinate 30 women with previously treated stage IV breast cancer. Expression of CD80 conferred the ability to deliver a costimulatory signal and thereby improved the antigen presentation capability of the tumor cells to patient T cells in vitro. Patients were vaccinated with 10(7) or 10(8) irradiated gene-modified tumor cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) or BCG, three times at 2-week intervals and then monthly until progressive disease developed. GM-CSF-related flulike symptoms and minor injection site reactions were observed frequently. Prolonged disease stabilization was observed in four patients but no objective tumor regressions were seen. Immune responses were measured in matched peripheral blood samples collected before and after treatment from 9 of 15 patients treated at the 10(8) tumor cell dose. Four patients exhibited MHC class I-restricted cytokine production in response to the parental breast cancer cell line. One patient maintained an increased number of circulating tumor-specific, interferon gamma-secreting CD8(+) T cells for 24 months after the last vaccination. One patient exhibited a tumor-specific interleukin 5 response to an autologous tumor cell line. This immunization strategy proved to be safe and feasible, and induced tumor-specific immune responses in a minority of patients; however, no objective tumor regressions were observed.
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PMID:Vaccination of women with metastatic breast cancer, using a costimulatory gene (CD80)-modified, HLA-A2-matched, allogeneic, breast cancer cell line: clinical and immunological results. 1288 50