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Query: UMLS:C0278134 (anesthesia)
 110,339 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Influence of a New Benzonaphtyridone Derivative (IFC-45) with Antidepressant Activity on the Central Nervous System. Part II: The Influence on the Amphetamine and Reserpine Effects and Other Pharmacological Studies. Pol. J. Pharmacol, Pharm. 1975, 27, 479--491. IFC-45 (chem. formula see p. I, page 471) potentiated amphetamine action in a similar manner as standard drugs, had significant but slightly less than the compared standards anti-reserpine activity. IFC-45 did not act anticonvulsivantly, did not affect physostigmine toxicity or evipan anaesthesia.
Pol J Pharmacol Pharm
PMID:The influence of a new benzonaphtyridone derivative (IFC-45) with antidepressant activity on the central nervous system. Part II. The influence on the amphetamine and reserpine effects and other pharmacological studies. 118 53

A transient rise of intracranial pressure in cats under chloralose-urethane anaesthesia increased the activity of the sympathetic vertebral nerve, cardiac nerve and in the first phase phrenic nerve. If the vagus nerves were intact this rise in sympathetic activity was associated with bradycardia. These effects developed with a delay, as a rule after abatement of the transient intracranial pressure rise. The authors suggest that Cushing's reaction is caused by medullary ischaemia and development of local metabolic acidosis activating simultaneously the sympathetic and parasympathetic neurons in the medulla oblongata.
Acta Physiol Pol
PMID:The effect of acute rise in intracranial pressure on the sympathetic cardiac, vertebral and phrenic nerve activities. 127 95

Esters of N,N-diethylaminoacetic acid and hydroxyamines, obtained from structurally different natural monoterpenes, were pharmacologically examined. It was proved that salts of the obtained compounds had local anesthetic properties in infiltration anesthesia, compounds 9, 6 and 8 having been more potent than lidocaine. Compounds 7-9 slightly increased the arrhythmogenic dose, and compound 12 - the lethal dose of strophanthin. All the examined compounds transiently decreased the arterial blood pressure and displayed a cardiopressive activity.
Pol J Pharmacol Pharm
PMID:Synthesis and local anesthetic and circulatory actions of aminoesters and hydroxyamine monoterpene derivatives. 128 4

A few derivatives of natural, bicyclic monoterpenes, which are propranolol analogs, were synthetized. Those compounds were studied pharmacologically in order to determine their toxicity, antiarrhythmic activity in selected experimental models of arrhythmia, the local anesthetic effect and influence on the cardiovascular system. The tested compounds showed a less potent or similar toxicity towards reference drugs, were devoid of an antiarrhythmic activity in the model of barium arrhythmia, yet some of them (compounds 9 and 12) increased the arrhythmogenic dose of strophanthin. All the compounds studied had a local anesthetic effect stronger than lidocaine in infiltration anesthesia, and compound 8--also in surface anesthesia.
Pol J Pharmacol Pharm
PMID:Propranolol analogs containing natural monoterpene structures: synthesis and pharmacological properties. 130 58

The intravenous administration of ketamine hydrochloride to fifteen patients undergoing surgery produced no change in circulating plasma dopamine-beta-hydroxylase (DBH), although it produced a significant increase both in systolic blood pressure (BP) and diastolic BP during anesthesia. Halothane anesthesia that depress BP also produced no change in plasma DBH activity.
Mater Med Pol
PMID:Changes in human plasma dopamine-beta-hydroxylase activity after ketamine and halothane anesthesia. 130 75

The results of injections of propofol and thiopentone intra-arterially are compared in rabbits according to histopathological criteries. Thirteen New Zealand type rabbits are used. Two ml of 2.5% Thiopentone and 2 ml of 1% Propofol are administered to the rabbits under anesthesia. Three days after, their ears are amputated and sent to this pathological blind examination. In both groups, we saw neither a morphological change along the vessel walls nor significant bleeding. But between the groups there was a significant difference about oedema. Consequently, 2.5% thiopentone which is routinely used after intra-arterial administration, may be responsible of the gangrenous change but it is discussable and it makes significant oedema in animal models although propofol does not have this effect.
Mater Med Pol
PMID:The histopathological comparison of the results of the intra-arterial injections of propofol and thiopentone in rabbits. 130 69

Experiments were performed on six male cats under nitrous oxide in oxygen anesthesia. Animals were paralysed and artificially ventilated. Subarachnoid hemorrhage (SAH) was produced by basilar artery puncture following clivectomy. After 10 minutes (3 cats) and 60 minutes (3 cats) the basilar artery was dissected and fixed for electronmicroscopic examination. Ultrastructural examinations revealed in the cytoplasm of the endothelial cells on the side of the vessel lumen, the presence of spherical or flattened cylindrical structures identified as Weibel-Palade bodies. In the endothelium of the proximal segment, 10 and 60 minutes after puncture, the number of these electron-dense bodies increased, and was higher than in the corresponding distal segment. The possible role of the Weibel-Palade bodies in SAH after-effects is discussed.
Neuropatol Pol 1992
PMID:The possible role of endothelium in prevention of rebleeding in experimental subarachnoid hemorrhage (SAH). 134 Sep 19

Three children aged 7, 9 and 11 were treated because of traumatic dislocation of the hip. There was one case of anterior and two cases of posterior iliac dislocation. The reduction was performed under general anaesthesia directly after admission. In two children derotational shoe for 6 weeks and a plaster for 3 weeks in third case were used in after treatment. The unweighing of the limb was maintained for 6 weeks more. Subsequently, the gradual weight bearing was allowed. Radiographic examination of two children 1.5 and 3.75 years after injury revealed normal hip joints. There was no restriction of physical activity of these children.
Chir Narzadow Ruchu Ortop Pol 1991
PMID:[Traumatic hip dislocation in children]. 136 79

The authors reviewed a series of 38 consecutive patients with trigeminal neuralgia treated by percutaneous thermocoagulation in 1984-90. In 10 patients in whom the result of the treatment was unsatisfactory the coagulation was repeated (in 2 out of 10 twice). The analysis of the results showed that good outcome was connected with permanent anaesthesia in the area innervated by the coagulated branch. If anaesthesia was not present 24 hours after the treatment, it suggested that an insufficient lesion was done and consequently unsatisfactory result was likely. In patients in whom there was a sensory impairment after either thermocoagulation or other form of treatment (injection of alcohol or rhizotomy) repeated thermocoagulation not only did not give good results but could lead to worsening of the pain.
Neurol Neurochir Pol 1992
PMID:[Late results of the treatment of trigeminal neuralgia by the method of thermocoagulation of the gasserian ganglion]. 140 3

Changes in the basic, hemodynamic parameters during the first 30 minutes of epidural anesthesia in relation of the dose, concentration, and volume of bupivacaine used are discussed. It was found, that in a proper epidural anesthesia a significant effect on the value of basic hemodynamic parameters was exerted only by a volume of administered bupivacaine solution, whereas its concentration or dose do not play any significant role. However, further prospective studies are necessary to extend this observation on the wider population.
Pol Tyg Lek
PMID:[Mathematical analysis of relations between dose, level or volume of bupivacaine and various hemodynamic parameters in epidural anesthesia]. 143 48


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