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Query: UMLS:C0278134 (anesthesia)
 110,339 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The experiments were performed on male rats, drinking 2% NaCl solution ad libitum for 12 days instead of tap water. The pituitary gland was exposed by the transpharyngeal approach under urethane-chloralose anaesthesia. The posterior lobe remained in neural and partial vascular connection with the hypothalamus, whereas the anterior lobe was entirely removed. Samples of the outflow medium from the incubated in situ rat posterior pituitary lobe were collected during 30 min intervals. Substance P-like peptides and vasopressin activities were assayed by the biological tests. Injections of hypertonic solution into the internal carotid artery did not change vasopressin release, but induced an increase in Substance P release from the posterior pituitary lobe into the incubation medium. Under conditions of unexcitability of the osmosensitive cells, triggering vasopressin release, the injection of hypertonic solution into the internal carotid artery stimulated the Substance P-like peptides release from the posterior pituitary lobe.
Acta Physiol Pol
PMID:Substance P-like peptides and vasopressin release from posterior pituitary lobe incubated in situ after intracarotid injections of hypertonic solution in rats. 2 85

Two hours of pentobarbital anesthesia resulted in marked elevation of serotonin (5-HT) level and decreased accumulation of 5-hydroxyindolacetic acid (5-HIAA) after probenecid, in specific parts of rat brain. In hypoxia, either no change (cortex, hypothalamus) or an increase (striatum, pons with medulla) in 5-HT content was observed. Concomitantly, the decrease of 5-HIAA level and its accumulation after transport inhibition occured. Pentobarbital pretreatment of hypoxic rats resulted in further diminution of 5-HT degradation after probenecid, having synergistic character in pons with medulla, which points to the specific sensitivity of serotonergic system in the latter area. Hypoxia-induced decrease of 5-HIAA level was prevented by pentobarbital pretreatment. The possible participation of 5-HIAA efflux inhibition in this phenomenon is discussed.
Pol J Pharmacol Pharm
PMID:Effect of pentobarbital anesthesia on serotonin metabolism in hypoxic rat brain. 4 Dec 28

Central action of catecholamines on the cardiovascular system in rats. Acta Physiol Pol., 1978, 29 (2): 123--130. It was demonstrated that noradrenaline, adrenaline, dopamine and isoproterenol as well as normethanephrine administered into the lateral ventricle of the rat brain, under urethane anaesthesia, caused significant changes in arterial blood pressure. This action is due to stimulation of central adrenergic receptors. Arterial blood pressure rise after intraventricular administration of noradrenaline is caused by activation of the renin-angiotensin system in the periphery. The results of these experiments point to a role of central catecholamines in functional regulation ofthe cardiovascular system.
Acta Physiol Pol
PMID:Central action of catecholamines on the cardiovascular system in rats. 20 81

The supraorbital branch of the trigeminal nerve of rats in chloralose anaesthesia was stimulated with electrical pulses. The stimulation of the afferent fibres of the trigeminal nerve evoked the retractive jerks of the outstretched tongue. These evoked tongue jerks (ETJ) were recorded on the tape of the line recorder through an isotonic transducer. The caniulae were inserted into the lateral cerebral ventricles by means of streotaxic apparatus and perfusion was performed with inflow of GABA or beta-phenyl-GABA-containing fluid into the right lateral ventricle and outflow through the left lateral ventricle. Perfusion with solution of 0.01 mol/l GABA reduced the amplitude of ETJ 25.9% while perfusion with hypertonic NaCl solution increased it by 19.5%, and perfusion with solution of 0.2 mol/l beta-phenyl-GABA reduced that amplitude by 39.9%.
Acta Physiol Pol
PMID:Inhibition of evoked tongue jerks during the rat's cerebral ventricles perfusion with gamma-aminobutiric acid and beta-phenyl-gamma-aminobutiric acid. 21 31

In the light of CSFP measurements by Lundberg's method in 46 patients the authors showed the role of hyperventilation in lowering of intracranial pressure. A considerable efficacy of dexamethasone was demonstrated as well, the use of this drug permitted to achieve stabilization of CSFP during and after the operation. The investigations showed a considerable effectiveness of such drugs as mannitol and furosemide in lowering of CSFP. Pancuronium was found to be superior to suxamethonium for administration during induction of anaesthesia because the former caused no CSFP rise. In polygraphic investigations of nocturnal sleep with parallel recording of CSFP a rise of CSFP was demonstrated during REM phase of sleep.
Neurol Neurochir Pol
PMID:[Cerebrospinal fluid pressure measurements in the ventricular system during and after surgery in patients with supratentorial brain tumors]. 21 39

The effect of increased concentration of vasopressin and oxytocin in the cerebrospinal fluid on the excitability of the hypoglossal nerve nucleus was investigated. The experiments were carried out on rats under chloralose anaesthesia. Retractory jerks of the outstretched tongue were evoked by supra- or infraorbital nerve stimulation during perfusion of the cerebral ventricles with McIlwain-Rodnight solution. The solution contained synthetic arginine vasopressin 0.05 U/ml or synthetic oxytocin 0.05 U/ml. Perfusion of the ventricles with vasopressin increased and perfusion with oxytocin decreased the evoked tongue jerks.
Acta Physiol Pol
PMID:Effect of vasopressin and oxytocin perfusion of the cerebral ventricles on evoked tongue jerks. 21 38

On dogs under Eunarkon anesthesia (0,03 ml Eunarkon/kg body weight) after one intramuscular lethal injection of phoschlor (500 mg/lg body weight = LD100) the proteolytic activity (APR) was estimated in the blood plasma at pH 3,5-APR-3,5 and in the hemolyzed blood at pH-7,4-APR-7,4. The results showed that heavy poisoning with phoschlor led to metabolic disturbances in the proteolytic system of the blood plasma and blood, the expression of which was increasing in the course of time a statistically important increase (alpha = 0,001) of APR-3,5 and APR-7,4. APR induction in blood is not a result of direct activation of enzymes by pesticides. It takes place outside the circulation system.
Pol Arch Weter 1979
PMID:[Proteolytic activity of blood plasma and hemolysed blood in dogs after acute chlorophos poisoning]. 40 Jan 84

For activation of electrocorticographic records the authors administered intravenously thiopental or Brietal to 86 patients undergoing operations for various types of focal epilepsy. Thiopental was administered either in intravenous drip infusion as 0.2% solution, or in a single injection of 2.5% solution. Brietal was injected as 1% solution intravenously. Thiopental activated electrocorticographic tracings in 56.3% and Brietal in 84% of the patients. In the conclusions the authors stress that both these agents may be used for activation of pathological discharges in ECoG in patients with epilepsy operated upon under general anaesthesia. Brietal seems to be better and it may be administered many times.
Neurol Neurochir Pol
PMID:[Comparison between thiopental and brietal in the activation electrocorticographic records in epileptics]. 40 22

In the reported case unilateral external ophthalmoplegia developed in a young woman, with concomitant pain and anaesthesia in the area innervated by the 1st branch of the trigeminal nerve. After ruling out an expanding lesion of the central nervous system, aneurysm, diabetes, myasthenia, multiple sclerosis and other diseases dexamethasone was administered in a total dose of 30 mg. Complete clinical remission was achieved. In the light of observations and a survey of the peritinent literature it has been accumed that the disease was caused by a non-specific process in the small vessels in the vicinity of the cavernous sinus.
Neurol Neurochir Pol 1979
PMID:[Tolosa-Hunt syndrome (ophthalmoplegia dolorosa)]. 52 41

The purpose of this work was to compare the oxytocic activity of plasma and posterior pituitary lobe extract in rats after sham operation, ovariectomy and after subcutaneous implantation of stilboestrol or progesterone tablets in ovariectomized rats. On the 5th day after ovariectomy or implantation of hormones, sample of 2 ml of blood were obtained under urethane anaesthesia from the cephalic end of the right external jugular vein, and the animals were killed by decapitation. The posterior pituitary lobe was removed and homogenized in 0.9% NaCl solution acidified with glacial acetic acid. The oxytocic activity of plasma and extracts of the posterior pituitary lobe was determined by the method of Van Dongen and Hays on fragments of lactating rat mammary tissue. On the 5th day after ovariectomy or implantation of stilboestrol the oxytocic activity was found to be significantly increased in the plasma and posterior pituitary lobe, and after progesterone implantation it was decreased in the posterior pituitary lobe.
Acta Physiol Pol
PMID:Oxytocic activity of plasma and posterior pituitary lobe after ovariectomy and implantation of stilboestrol or progesterone tablets in female rats. 53 70


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