Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278134 (anesthesia)
 110,339 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Author looks over the novelties in anaesthesiology in the 90-ies; (1) effort to relief not only the postoperative, but in general, every kind of pain; (2) publication of evidence based guidelines; (3) standpoints according to perioperative risk factors; (4) conception of preemptive analgesia; (5) usage of modern brain imaging techniques in anaesthesiology also; (6) researches about the sites, where general anaesthetics exert their effect; (7) new volatile anaesthetics (desflurane, sevoflurane); (8) researches, targeting the use of xenon; (9) new i.v. anaesthetics-analgesics (propofol, remifentanil, S(+)-ketamine, eltanolone) and their administration (TCI); (10) potential interactions between NO and anaesthetic agents; (11) new neuromuscular blocking drugs (mivacurium, rocuronium, cis-atracurium) and the new possibilities of neuromuscular monitoring; (12) question of difficult intubation (McCoy and bullard laringoscopes, laryngeal mask); (13) synthesis of the new elements for the challenges of the surgical practice: the anaesthesiological solution of laparoscopic surgery, one-day surgery, minimally invasive heart-surgery; (14) TIVA (recognition of awareness during operation); (15) closed circuit anaesthesia; (16) reduction of expenses; (17) application of computer and data management techniques; (18) organizational steps in order to achieve an integrated standard throughout the country.
 ...
PMID:[Advances in anesthesiology in the 90's]. 960 64

This paper describes practical aspects relating to the safe use of target controlled infusion systems in anaesthesia. Consideration is given to the correct use of syringes and infusion lines for any target controlled infusion system. The importance of appropriate connections, minimising infusion line dead space and the avoidance of syphoning are emphasised. The first two commercially available infusion pumps to incorporate the 'Diprifusor' module for the administration of propofol by target controlled infusion are the Graseby 3500 (Graseby Medical Ltd) and the Vial Master TCI (Fresenius Vial SA, originally developed by Becton Dickinson). Particular features of these systems are discussed. Finally, the practical consequences of possible misuse of infusion systems incorporating pharmacokinetic models are considered.
Anaesthesia 1998 Apr
PMID:Practical use of 'Diprifusor' systems. 964 Jan 12

In this multi-centre, randomized trial, we compared the safety and efficacy of Diprifusor TCI with manually controlled infusion (MCI) of propofol for anaesthesia. With approval, 123 adult male and female patients were studied. Firstly, each investigator anaesthetized five patients to familiarize themselves with Diprifusor TCI. In Stage 2, 98 patients were randomized to receive propofol-based anaesthesia via TCI or MCI. Adjuvant drugs, airway management and monitoring were managed at the discretion of the anaesthetist. Results are presented as mean (SD). Induction times were significantly longer [67 (32) vs 54 (17)s] and induction doses were significantly lower [14 (5) vs 16 (4) ml] in the TCI vs the MCI group. Recovery times and total doses were not significantly different. There were statistically but not clinically significant differences in mean arterial blood pressure and heart rate. Quality of anaesthesia and ease of control of anaesthesia were similar. We conclude that Diprifusor TCI and MCI are similar in terms of safety and efficacy.
 ...
PMID:Safety and efficacy of target controlled infusion (Diprifusor) vs manually controlled infusion of propofol for anaesthesia. 1038 58

Total intravenous propofol anesthesia with target control (TCI) infusion was used in 61 surgical patients (43 women, 18 men, ASAI-II). Propofol concentration in the central compartment at awakening was in high correlation with the effective concentration (Ce) at the moment of falling asleep (r = 0.64). A model investigation demonstrated the advantages of longer induction for minimization of the hemodynamic disorders. Propofol TCI in a dose of 2 micrograms/ml led to an increase in the EEG spectral potency in the 1-12 Hz range, appearance of biomodality, and a decrease in the right-side frequency. The studies helped determine the policy of intravenous propofol TCI anesthesia using the Ce values at the moment when the patient lost consciousness and the right-side frequency of EEG spectrum.
 ...
PMID:[Total intravenous anesthesia based on propofol infusion with target concentration: a new procedural solution]. 1083 30

Twenty patients were prospectively and randomly studied to investigate effects of infusion methods of propofol on quality of sedation and ease of sedation control during gynecological laparotomy under spinal anesthesia. After establishment of spinal anesthesia, patients were randomly assigned to one of the following two groups, i.e. conventional continuous infusion group (Cont group) and target-controlled infusion group (TCI group). In the Cont group, propofol was started at a rate of 6 mg.kg-1.hr-1 until response to command disappeared. In the TCI group, the initial target concentration of propofol was set at 1.2 micrograms.ml-1 until response to command disappeared. Thereafter infusion rate or target concentration was adjusted to maintain Mackenzie's score at 3 or 4. Predicted concentration of propofol was 1.2 +/- 0.01 micrograms.ml-1 at induction of sedation and 1.2 +/- 0.11 micrograms.ml-1 during stable sedation in the TCI group. Satisfaction VAS, anxiety VAS, discomfort VAS, sedation score and times of changing infusion condition were similar in both groups. Total dose of propofol was significantly less in the TCI group. In conclusion, quality of sedation and ease of control of sedation were comparable in both groups and continuous infusion method is simple.
 ...
PMID:[Effects of infusion methods of propofol on quality of sedation and ease of sedation control during gynecological laparotomy under spinal anesthesia]. 1107 58

The benefits of using endoscopic TCI for frozen semen come from being able to achieve the same or better results without the need and risks of general anesthesia and surgery. The ability to do all fresh and chilled inseminations this way will certainly improve conception rates without the owner having to make a decision about exposing their bitch to the risks of anesthesia and surgery. The other potential uses open up a whole new field for canine theriogenology. Above all, the client response to the technique is overwhelmingly positive. At times the learning process will be discouraging, but the end result is worth the effort. The endoscope should not be treated as something special for frozen semen insemination but should be used at every opportunity in order to develop experience and expertise in all situations.
 ...
PMID:Transcervical insemination techniques in the bitch. 1126 93

Sixty unpremedicated healthy adult patients were studied during induction of anaesthesia with intravenous propofol delivered by a 'Diprifusor' target-controlled infusion. Bispectral index (BIS) and spectral edge frequency (SEF95) were measured concurrently with the predicted blood and effect site propofol concentrations. Logistic regression was used to calculate the predicted propofol blood and effect site concentrations required to produce unconsciousness and no response to a noxious stimulus in 50% and 95% of patients and to correlate BIS with these end-points. The Diprifusor TCI software produces anaesthesia at consistent target concentrations. Bispectral index correlates well with clinical end-points and may be useful during propofol anaesthesia.
Anaesthesia 2002 Mar
PMID:Propofol effective concentration 50 and its relationship to bispectral index. 1187 13

The growing importance of ambulatory surgery during the past decade has led to the development of efficient anesthetic techniques in terms of quality and safety of anesthesia and recovery. In these challenging objectives, intravenous techniques have played an important role, as they provide safe, efficient, and cost-effective anesthesia in the ambulatory setting. Among the numerous intravenous drugs, propofol, with its fast and smooth onset of action, short duration of action, and low incidence of postoperative side effects appears to be the anesthetic of choice in this situation. The recent development of new techniques of administration (such as TCI, monitored anesthesia care, or patient-controlled sedation) and monitoring (such as the BIS and the availability of "hit and run" drugs such as remifentanil) will optimize intraoperative conditions and recovery, thus allowing faster home readiness in the ambulatory setting.
 ...
PMID:Intravenous techniques in ambulatory anesthesia. 1281 95

Myocarditis is often self-limited and without sequelae, most commonly the result of the viral infection. Recently it has been pointed out that there are some cases of myocarditis progressing to a chronic phase like dilated cardiomyopathy. Worsening congestive heart failure and findings of new electrocardiographic changes are the most catastrophic, sometimes fatal, perioperative events. We experienced a case of a 45-year-old woman with previous history of idiopathic acute cardiomyopathy for non-cardiac surgery. For electrocardiogram monitoring, a five-lead system to detect the intraoperative ischemic events was used to detect frequent ST-T-wave abnormalities. Reducing cardiac irritability and preventing infection are the main points for this anesthetic management. We gave general anesthesia, not combining with epidural anesthesia, to avoid epidural abscess which may cause recurrence of myocarditis. We employed total intravenous anesthesia (TIVA) technique using propofol administration with TCI system and repetitive fentanyl injections. Propofol target concentration was titrated according to bispectral index (BIS) between 40-60. The patient emerged quite well within 20 minutes after discontinuing propofol. We could maintain hemodynamics stably and no severe adverse effects were observed perioperatively. Thus this anesthesia technique was safe and useful to maintain the hemodynamics stably in the case with previous history of idiopathic acute cardiomyopathy.
 ...
PMID:[Anesthetic management with total intravenous anesthesia for a patient with previous history of acute myocarditis]. 1516 Jun 66

Forty women under general anaesthesia (computer-controlled TCI-infusion) in two groups were subjected to non-invasive haemodynamic monitoring together with arterial gasometry and capnography. Simultaneous continuous monitoring of aortic blood flow and PetCO2 allows an undelayed recognition of major circulatory disturbances, before significant changes in heart rate and arterial pressure occur.
 ...
PMID:[Respiratory and hemodynamic monitoring during laparoscopy and two computer-controlled TCI anesthesiologic technique]. 1518 26


1 2 3 4 Next >>