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Query: UMLS:C0278134 (anesthesia)
 110,339 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The cardiodepressive effects of ketamine (1mg/kg), etomidate (0.3mg/kg), methohexitone (1mg/kg) and propanidid (4mg/kg) have been compared by means of the systolic time intervals on patients during a steady-state halothane--N2O:02(1.1)-- anaesthesia. This anaesthesia served as a pharmacological model of reduced myocardial function, and moreover, it should block the centrally-elicited cardiac stimulation by ketamine, thus unmasking the direct negative inotropic action of this anaesthetic. Ketamine and etomidate are of lesser cardiac depressant action than methohexitone or even propanidid. Diazepam (0.2-0.25mg/kg) proved to be able to attenuate or abolish, respectively, the ketamine-induced increases of heart rate and blood pressure in normo- and hypertensive patients, and might therefore be useful for induction anaesthesia in cardiac and coronary risk patients, as proved on two patients with recent myocardial infarction.
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PMID:[Cardiodepressive effects due to ketamine, etomidate, methohexitone and propanidid. A clinical study by means of the systolic-time-intervals (author's transl)]. 101 52

In the young child, the ocular tension cannot be taken without general anesthesia. Most of the anesthetic drugs lower the ocular tension which may give false low results in glaucoma. Ketamine is the only practical drug elevating the ocular tension. To determine the amount of the change in ocular tension under ketamine, the ocular tension was measured under I.M. ketamine 5 to 10 mg/kg in 30 children without ocular disease. The ocular tension before the anesthesia has not been measured. As soon as the child fell asleep, the ocular tension was recorded between 15 to 20 minutes. We noticed that the ocular tension remains stable in the beginning, but that it tends to rise after eight minutes of narcosis. So the ocular tension must be measured as soon as possible after induction, as soon as the child does not react to stimuli. Abnormal ocular tensions under ketamine are discussed. The ocular tensions under two different types of anesthesia (ketamine and methohexital + Thalamonal) are compared. Some examples of ocular tensions in glaucoma under ketamine are presented.
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PMID:Ocular tonometry in the child under general anesthesia with IM ketamine. 101 31

Until recently Ketamine has been the anaesthetic most commonly used for electrocochleography. It was believed that the use of a conventional anaesthetic machine would produce artifacts in the recordings but experience has shown that this is not the case; in fact quieter tracings are obtained due to the abolition of muscle potentials. Ketamine is preferred for children under 3 years old but the others receive a general inhalation anaesthetic. The intramuscular route is chosen for the administration of Ketamine in order to minimize the occurrence of hallucinations in the recovery period. Consistent results have been obtained with a dosage related to the metabolic rate of the child. One milligram of Ketamine is administered for each 35 cm2 of surface area. General inhalation anaesthesia is given by a semiopen circuit and an oral endotracheal tube is used. Induction is with methohexitone or nitrous oxide and halothane, and maintenance is also with nitrous oxide and halothane. The main drawback is pollution of the atmosphere of the sound-proofed testing room with halothane. This has been overcome by ducting the expired gases outside the room using an Enderby valve.
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PMID:Anaesthesia for electrocochleography. 103 39

Definition and classification of glaucomas. Indication of drugs contraindicated in glaucomas. Discussion of the problem of tonometry in anaesthesia in congenital glaucoma suspicion with special regard to factors influencing intraocular pressure. Discussion of correlation between intraocular pressure and systemic blood pressure. Report on own experiences with Ketamine and discussion of advantage and disadvantage of the drug for tonometry in anaesthesia in infants. Explanation of the method of impression--and applanation tonometry with regard to Glaucotest, a new borderline--tonometer suitable for the anaesthesiologist.
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PMID:[Glaucoma, tonometry and anaesthesia (author's transl)]. 109 67

Ketamine [dl-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone] hydrochloride was used in conjunction with Acepromazine [10-3-(dimethylamino)-propyl]phenothiazin-2-yl-methyl ketone] Maleate to produce surgical depth anesthesia in guinea pigs. In tests with 97 animals, an intramuscular injection of 44 mg/kg ketamine hydrochloride plus 2 mg Acepromazine Maleate was found to be effective in producing a surgical level of anesthesia within 2 min after administration. The anesthetic state lasted for an average of 1.5 h and could be safely extended by supplemental administrations of the drugs. This anesthetic combination was found to be fast acting, safe, and easily controlled.
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PMID:A safe and fast-acting surgical anesthetic for use in the guinea pig. 115 May 67

Ketamine, a rapid-acting general anesthetic, was administered intravenously to 26 epileptics. The effects of ketamine on the patients' clinical seizures and electroencephalograms were compared with similar periods during alert and sleep states. Epileptic discharges were present in the alert electroencephalogram of 17 (65 percent) of the patients. Epileptic discharges were precipitated or aggravated by sleep in 15 patients (58 percent) and by ketamine in eight patients (31 percent). No siezures were recorded during ketamine anesthesia. Ketamine neither precipitates nor aggravates seizures and is less effective than natural sleep as an activator of epileptic discharges.
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PMID:Effects of ketamine in epilepsy. 116 44

Regional anesthesia employing the spinal, epidural, or caudal approach was used to anesthetize 200 children, varying in age from 17 days to 15 years. Lidocaine in concentrations varying according to age was used. Ketamine (1 to 2 mg./kg.) was given in the majority of cases to ensure a quiet patient prior to block. No major anesthetic complications or deaths were attributable to the anesthetic technic. The caudal approach proved easiest.
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PMID:Regional anesthesia in children. 116 30

To study the effects of Ketamine and Innovar on renal function, the renal cortical and medullary blood flows of dog were measured using a thermo-electrical flowmeter, along with the urine output, blood pressure and pulse rate. Ketamine decreased the renal cortical blood flow and the urine output. Innovar increased the renal cortical blood flow, but did not alter the medullary blood flow appreciably, and decreased the urine output. Neither of these variations in renal blood flows ran parallel with variations in the arterial pressure nor did variations in the urine output run parallel with those in the blood flows. All anaesthetic agents are inhibitory to kidney, but Innovar may be preferred to other anaesthetics in view of the finding that the renal blood flows are well maintained even under anaesthesia with this agent.
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PMID:The effects of ketamine and innovar on the renal cortical and medullary blood flow of the dog. 120 Mar 37

In 68 from 1- to 14-years-old children rectal temperature was measured in Ketamine and Halothane anesthesia and with room temperatures ranging from 22-25 and 26-28 degree centigrade, while orthopedic repair operations were performed on the extremities. Independent of the quality of the premedication, which consisted either of Ketamine (Atropine or Thalamonal) Atropine a significant rise in temperature of 0,4 to 0,5 degrees C. was found within one hour of Ketamine anesthesia, but only with room temperatures of 26-28 degrees C., while with lower room temperatures (22-25 degrees C.) rectal temperature remained unchanged. The rise in temperature occurred both in Ketamine monoanesthesia with spontaneous respiration and in Ketamine-N2O-O2 anesthesia with respiration controlled.
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PMID:[Clinical investigations of the temperature effects of ketamine and halothane in children (author's transl)]. 123 68

Ketamine is an induction agent. This experimental study was designed to investigate the immediate effects of ketamine upon haemodynamics, inotropism and myocardial oxygen consumption during induction. In a circulatory steady state of a piritramide - nitrous oxide - oxygen basic anaesthesia normoventilated dogs (n = 8) received intravenous injections of 5.0 and 10.0 mg/kg ketamine within 30 sec at random. Immediately after administration of 10.0 mg/kg ketamine the cardiac output (thermo dilution method) rose (27%) on account of tachycardia while the total peripheral resistance (40%) and the mean arterial pressure (23%) decreased. The decrease in stroke volume (37%) and the inotropic parameter dp/dt max (42%) as well as the increase in the end-diastolic left ventricular pressure (31%) and in the pressure of the pulmonary artery (11%) suggest considerable myocardial depressor properties of ketamine. The change in haemodynamics was paralleled with an increase in myocardial oxygen consumption (47%), which was initially met by an increase in coronary blood flow (25%) and an additional oxygen utilization (20%). The increase in arterio-coronary venous oxygen difference is believed to be due to a constriction of the coronary arteries after ketamine. Since external cardiac work remained unchanged,while myocardial contractility and myocardial wall tension (Psyst) decreased, the increase in heart rate (63%) explains the rise in myocardial oxygen consumption. The efficiency of cardiac work, which is defined as the ratio of myocardial displacement work to myocardial energy demand, decreased (31%) and illustrated the uneconomic work of the heart under the influence of ketamine. The clinical utilization of the data obtained from this study are discussed.
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PMID:[The effect of ketamine on haemodynamics and myocardial oxygen consumption in anaesthetized dogs (author's transl)]. 123 85


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