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Query: UMLS:C0278134 (anesthesia)
 110,339 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Numerous reports have described a definite sense of well-being after anesthesia with propofol (Disoprivan). The present study was designed to assess postoperative mood as recorded with a quantitative self-rating method. Postoperative recovery and amnesia were also investigated. Thirty unpremedicated female patients aged 20-60 (ASA grade 1 or 2) who were scheduled for minor gynecological operations were enrolled in the study after informed consent. The patients were randomly allocated to three study groups: group A, induction with propofol 2 mg/kg and maintenance with propofol 0.15 mg/kg per min together with N2O/O2; group B, induction with propofol 2 mg/kg and maintenance with enfluran and N2O/O2; group C, induction with thiopental until loss of the eye lash reflex and maintenance with enfluran and N2O/O2. Postoperative amnesia was assessed by showing five picture cards at 5-min intervals, starting when the patients were able to state the correct date of birth. A test of recovery (p-deletion) was carried out after 30 and again after 60 min. The postoperative mood state was evaluated with the adjective checklist of Janke and Debus 5 h after waking. In good agreement with published reports, propofol patients recovered more rapidly than thiopental patients. A significant but irrelevant amnesia occurred after 5 min in group B. However, in some cases amnesia lasting up to 20 min was observed. The global mood status showed a significantly higher score for positive items and a lower score for negative items after propofol administered by either technique than after thiopental (P = 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Recovery, amnesia and affective state following propofol in comparison with thiopental]. 219 98

The effects of Disoprivan on cerebral blood flow (CBF), cerebral oxygen consumption, and CO2-reactivity of the cerebral vessels were studied in 11 male patients between 49 and 63 years of age who were about to undergo coronary artery bypass surgery. Mean perfusion pressure was decreased by 25% under anaesthesia by 0.2 mg/kg per minute Disoprivan, but remained within the ranges of autoregulation. CBF decreased by 51% and cerebral vascular resistance (CVR) increased by 55% following a 36% decrease in cerebral oxygen consumption which was associated with a decrease in neuronal activity in the EEG. Hyperventilation led to a 25% further decrease in CBF due to a 43% increase in CVR while cerebral oxygen consumption remained unchanged. Hypoventilation was followed by a 67% increase in CBF and a 44% decrease in CVR cerebral oxygen consumption was decreased by 38%. This study shows that the reactivity of the cerebral vessels to changes in paCO2 is well maintained under Disoprivan.
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PMID:[Effect of Disoprivan (propofol) on the circulation and oxygen consumption of the brain and CO2 reactivity of brain vessels in the human]. 310 19

In a preliminary pilot study, the effect of disoprivan for sedation during regional anesthesia was investigated. In 15 patients (ASA I or II), lumbar epidural anesthesia with bupivacaine 0.75% was performed at L 3/4. For premedication morphine or pethidine combined with scopolamine was given. After injection of the local anesthetic, a 30-min period was allowed for establishing the physiological side effects of epidural blockade, to present any further changes in circulatory and/or cardiac function. Disoprivan (1 mg/kg body weight) was injected i.v. followed by continuous disoprivan infusion. Three groups of 5 patients each were given 1, 1.5, or 2 mg/kg per hour disoprivan. Changes in heart rate, blood pressure, and respiratory rate were studied. Recovery time and personal assessment of sleep were registered. Side-effects of clinical relevance from the cardiovascular and pulmonary systems were also registered. A dose-dependent upper airway obstruction that could easily be managed by an oral or nasal airway was seen in 9 of 15 patients. Eight patients had postoperative nausea or vomiting; 9 complained of pain during the bolus injection that they could not remember postoperatively. All patients described their sleep as pleasant. Recovery time from sleep was between 1 and 12 min. All changes from normal values increased in percentage with increasing disoprivan dosage. Disoprivan (1 or 1.5 mg/kg per hour) seems to be excellent for sedation during regional anesthesia and is perhaps even superior to other available drugs.
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PMID:[Disoprivan (Propofol) sedation during regional anesthesia. A pilot study]. 325 31

Disoprivan (Propofol) was used for induction and maintenance of anaesthesia for short surgical procedures in non-premedicated and premedicated (0.5 mg atropine, 3 mg midazolam) patients. A dose of 130-150 mg Disoprivan was adequate for induction, and a dose of 72 and of 62 micrograms/kg body weight/min anaesthesia respectively, for maintenance, together with N2O/O2 2:1. The anaesthesia was characterized by an apnoea of 40-60 s duration, a decrease in arterial blood pressure of 20%, a slowing of heart rate in non-premedicated patients by 12 beats/min and a rapid and pleasant recovery with lack of emetic sequelae. Disoprivan is considered useful for this type of anaesthesia.
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PMID:[Disoprivan for the induction and maintenance of short anesthesia]. 349 Aug 2

The purpose of this study was to evaluate disoprofol as the hypnotic for total intravenous anaesthesia. Sixty women undergoing minor gynaecological surgery participated and were randomly assigned to four groups (N = 15 in each group). Disoprofol, 2 mg/kg was given i.v. to induce anaesthesia after a bolus injection of either fentanyl 1.875 micrograms/kg or alfentanil 18.75 micrograms/kg. Vecuronium, 0.06 mg/kg, was given for muscle relaxation when indicated. One-half of the patients received acute premedication with midazolam, 5 mg i.v. Anaesthesia was maintained with a continuous infusion of disoprofol 150 micrograms/kg/min and either fentanyl 0.125 micrograms/kg/min or alfentanil 1.25 micrograms/kg/min. These drug combinations were compatible and produced good operating conditions. Awakening time was significantly shorter for women who received no premedication and was not affected by the narcotic used. Respiration returned more quickly when fentanyl was the narcotic given and was not affected by premedication. Both hypotension and bradycardia were seen in some patients, but other side effects were infrequent. This total intravenous anaesthesia technique was very well accepted by the patients and the nurses who cared for them in the postoperative period.
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PMID:Disoprofol (ICI 35868) for total intravenous anaesthesia. 640 21

Disoprofol has been used to induce and, by continuous infusion, to maintain a light level of general anaesthesia in 100 patients undergoing surgery with the aid of a regional block. Its effects have been compared with 100 patients anaesthetised in a similar manner with Althesin. Disoprofol proved to be a very satisfactory agent for use by this method and apart from an appreciable incidence of pain on injection the number of complications was small and comparable to those found with Althesin, which caused more involuntary movements. Recovery was particularly rapid and clear-headed following disoprofol, and occurred highly significantly more quickly than after Althesin. Disoprofol, however, will not be marketed in the present formulation which has Cremophor EL as the solubilising agent.
Anaesthesia 1982 Mar
PMID:Continuous intravenous infusion of disoprofol (ICI 35868, Diprivan). Comparison with Althesin to cover surgery under local analgesia. 697 52

The duration of sleep following intravenous administration of three doses of disoprofol (1.2 and 3 mg/kg) was compared with that following methohexione 1 or 2 mg/kg. Disoprofol and methohexitone were shown to be approximately equipotent. Side-effects were dose-related for both drugs, but the incidence was significantly less following disoprofol than methohexitone 2 mg/kg. The most frequent side-effects were pain on injection, myoclonia and hiccup. Studies of blood concentrations of disoprofol show that the profile is dose-independent and conforms to a two-compartment model with a very short distribution phase (about 2 minutes) and short elimination phase (about 70 minutes). Waking blood levels gave no indication of acute tolerance. Disoprofol would appear to be particularly useful for induction of a short period of sleep using a small dose given quickly, or for maintenance of sleep by continuous infusion.
Anaesthesia 1981 Sep
PMID:Dose-response relationship for disoprofol (ICI 35868; Diprivan). Comparison with methohexitone. 703 Jan 20

Electroencephalographic (EEG) recordings performed in piglets during Trapanal anaesthesia showed distinct changes in bioelectrical brain activity in some piglets when castration was carried out. Only an additional extradural anaesthesia seemed to interrupt the transmission of peripheral pain stimuli to the central nervous system. Based on the protocol used EEG did not reveal a marked response to noxious stimulation. Castration of piglets up to two weeks of age were performed during general anaesthesia with Trapanal or Disoprivan or local anaesthesia with Hostacain or without any anaesthesia. The different modes of anaesthesia have had no effects to postoperative wound healing and weight gain between groups as well as between males and females within single groups. With regard to insufficient analgesia and/or partially extreme secondary effects the application of investigated anaesthetic methods on the occasion of castration of piglets is not justifiable at present. Castration in piglets up to an age of two month without anaesthesia is allowed by the animal protection law. However, due to improved wound healing and decreased response to surgical stimulus we suggest to perform castration during the first 10 days after delivery.
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PMID:[Piglet castration--pain sensation and pain elimination]. 820 50

Full-field electroretinograms were obtained from 20 normal children during general anesthesia and compared with electroretinograms obtained with topical anesthesia. Disoprofol and fentanyl induced a reduction in the b-wave amplitudes and an increase in the cone b-wave implicit time, but the changes were small and fall within the range limits seen with topical anesthesia (i.e., average +/- 2 SD).
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PMID:Full-field electroretinograms during general anesthesia in normal children compared to examination with topical anesthesia. 824 80

The injection anaesthetic propofol (Disoprivan) was used in 85 cats for performing gastroduodenoscopy. Anaesthesia and feasibility for executing endoscopy were evaluated. Two cats suffered from a transient (30 sec) respiratory arrest. In any other cases stable cardiovascular and acceptable respiratory conditions were observed. The endoscopy was easy to perform and no emesis was induced. Anaesthesia of the cat with propofol can be very well controlled. It is characterised by gentle induction and a recovery free from excitation.
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PMID:[Propofol--a short-term narcotic--tested in gastroduodenoscopy in the cat]. 847 Jan 10


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