Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0278134 (anesthesia)
 110,339 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

39 selected patients had their inguinal herniae repaired on 41 separate occasions in a health center. Local anaesthesia allowed adequate painfree surgery when supplemented with Diazepam and Pentazocin. All patients could return to their own homes within 6 hours. With an observation time of between one month and six years no recurrences have so far been observed. Apart from a mild post-operative pain, there were no complications. All returned to their normal employment after 5 to 32 days (average 20 days) depending on occupational demands. The pros and cons of out-patient surgery under local anaesthesia are discussed.
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PMID:Inguinal herniorrhaphy in a health center. 49 70

In previous studies we demonstrated the adverse effects of ethyl alcohol in murine head injury. Using this model in this study, effects of prior administration of pentazocine (Talwin) on the survival of mice are reported. Swiss Webster mice were randomly divided into one of three groups. Group I (n = 20) received pentazocine and Group II (n = 20, controls) received saline. Groups I and II were then injured under ether anaesthesia by allowing a weight to fall from a height of 15 cm on the cranium. Ten animals received pentazocine and were anaesthetized but had no head trauma (Group III). In Group II, 85% survived 24 h, and in Group I, 35% survived; all mice in Group III survived 24 h (significance: chi 2, p less than 0.005; Group I versus Groups II and III). Pentazocine increases the lethality of murine head injury.
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PMID:Effects of pentazocine in experimental head injury. 204 10

The study investigated the possibility of pharmacological servical ripening induced by Dinoprostone (Prepidil Gel--Upjohn Co) prior to therapeutic abortion in primigravida. The study concerned patients-volunteers choosen by random. 73 patients were divided into two groups with the same average age, term of gestation, cervix consistency and passage through the cervical canal before the application of gel. In the first group therapeutic abortion was carried out 6 hours after the application of gle into cervical canal, and in the second group--4 hours after the gel application. Cervical maturation, testified by its consistency and spontaneous cervical ripening, was equal in both groups (average delta Hegar I was 7.32 and delta Hegar II--7.02), and it enabled medical procedure only with the local anaesthesia with 2% hylocein in 82% ob pregnant women. In a fifth of patients ob both groups it was necessary to do additional mechanical dilatation, which was easily performed due to the already soft cervix; these patients were also administered 1 ampulla ob Fortral I.V. In both groups during the action of Dinoprostone there were no significant changes either in blood pressure or in body temperature. More expressed uterine activity, followed by initial and incompleted abortions, were more frequent in patients of the first group (3529%) than in those from the second group (17.95%) in which only contractions occurred (33.33%). The rate of gastrointestinal side effects was 29.41% in the first group and 41.03% in the second group. There was no uterine complication during the activity of Dinoprostone as well as during and after medical procedure.
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PMID:[Cervical maturation using Prepidil gel in pregnancy termination in primigravidas]. 221 33

Twelve systemically healthy patients each (ASA risk groups 1-2) who required oral surgery under local anesthesia received the short-acting benzodiazepin Midazolam for analgosedation as well as the analgesics Pentazocin or Piritramid. Both i.v. medications are suitable as adjuvants for local anesthesia since neither clinically relevant respiratory and circular depression nor major sleepiness were observed.
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PMID:[Analgosedation as an adjuvant during surgery under local anesthesia]. 263 69

Myasthenics must be considered as surgical risk patients. It is imperative to know the exact pathophysiology of the disease pattern with its three types of crisis including their treatment in order to perform safe anaesthesia and to reduce the rate of perioperative complications. In the preoperative phase we must consider a few specific angles besides the routine manipulations: Treatment with cholinesterase inhibitors as practised in myasthenics is continued unchanged or with only slightly reduced dosage up to the day of the operation. If necessary, oral administration may be changed to intramuscular or intravenous application. Premedication is carried out as far as possible without any drugs contraindicated in myasthenics. The patient may get regional or full anaesthesia, the latter always via intubation. We prefer inhalation anaesthetics because they are easily monitored. Neuroleptanalgesia, however, is also possible. One must accept the somewhat higher risk of postoperative respiratory insufficiency since in most cases subsequent artificial respiration must be performed anyway. Relaxation is effected, if at all necessary, via a non-depolarising muscle relaxant in low dosage (one-half to one-tenth of normal dosage). Measurement and monitoring of neuromuscular transmission via the nerve stimulator is mandatory. Succinylcholine is used only in case of vital indication (half of the normal dose). After surgery the patient is transferred to the intensive care ward in intubated position, extubation being performed only after spontaneous breathing has been safely assured. In postoperative analgetic treatment the opiate antagonist pentazocine (Fortral) showed the best results as far as our experience goes. With careful monitoring, however, it is also possible to employ other highly effective analgesics.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Myasthenia gravis as an anesthesia risk]. 301 75

A new short general anaesthesia for minor gynaecological operations is presented, which is also suitable for out-patients. The patient receives 0.05 mg. Atropin and 10 mg. Diazapam i.m. 30 minutes prior to the operation. Pentazocin in a dosage of 0.75 mg/kg. body weight was injected intravenously. 1 minute later Etomidate in a dosage of 0.3 mg/kg. body weight was injected intravenously. 1/3 of the initial dose of Etomidate was given as necessary at an average of 5 minutes following the initial dose. Through-out the procedure the patients spontaneously breathe room air. As advantages of the method are listed the minimal disturbances of the heart and the circulatory system, the lack of respiratory depression, the lack of specific organ toxicity, the absence of measurable release of histamine, the unlimited frequent repetition possible, the lack of damage to the personnel by anaesthetic gases and the safety and simplicity of the anaesthesia.
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PMID:[Short gynaecological general anaesthesia with pentazocin and etomidate combined with room air (author's transl)]. 677 9

The influence of an i. v. anaesthesia with Pentazocin/Etomidate on heart rate, arterial pressure and bood gases under spontaneous breathing of room air has been investigated on 50 patients with surgical and urological diseases. Heart rate, arterial pressure, pH, HCO3- and pO2 remained unaltered. There was only a slight increase in the beginning of the anaesthesia after injection of Pentazocin in pCO2 and a decrease in oxygen saturation which both were slightly significant. The use of this anaesthesia for ambulatory care is discussed.
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PMID:[Pentazocin/etomidate, an intravenous anaesthesia under spontaneous breathing of room air (author's transl)]. 678 74