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Query: UMLS:C0278134 (anesthesia)
 110,339 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

C57B1/6 mice were given intravenous tumor cells on day O. Mice were then given either a brief exposure to halothane anesthesia or given halothane and then underwent a hind limb amputation. Immune testing was done at varying time intervals and correlated with the development of artificial pulmonary metastases. The effects of a single 15 minute exposure to halothane on the immune system are probably short-lived and no effect on cell-mediated cytotoxicity was seen on day 7, nor was an increase in pulmonary metastases observed. However, when anesthesia was combined with surgery, cell-mediated cytotoxicity was impaired and an increase in pulmonary metastases was seen. The use of thiabendazole (TBZ), an nonspecific immunopotentiator, in the perioperative period restored the cell-mediated cytotoxic response and resulted in a significant decrease in pulmonary metastases.
Cancer 1978 Mar
PMID:Halothane, surgery, immunosuppression and artificial pulmonary metastases. 63 70

The effects of operation (lower-limb amputation) on the growth of the Lewis lung tumour and its metastases were studied. The role of C. parvum in counteracting these effects was investigated. Anaesthesia alone or with amputation did not affect primary tumour growth. C. parvum depressed this growth. Anaesthesia did not affect the number of pulmonary metastases, but amputation caused a significant increase. C. parvum inhibited metastases and completely counteracted the effects of operation on them. Large doses of cortisone acetate significantly increased metastases but small doses had no effect. Experiments with adrenalectomized mice suggested the effects of operation were due to non-specific stress.
Br J Cancer 1978 Apr
PMID:Effects of amputation and Corynebacterium parvum on tumour metastases in mice. 64 27

Records of 15 patients having hidden-loop colostomies were reviewed. All patients had metastatic colonic cancers with impending obstructions. Six colostomies were subsequently opened because of obstructions due to cancer. All colostomy openings were done using local anesthesia in the emergency room. This technique prevented six major celiotomies and provided additional time of living without a stoma. There were two postoperative stomal prolapses, one of which necessitated reoperation. A hidden-loop colostomy is easily constructed and readily opened. It should be considered at celiotomy for selected patients who have metastatic colonic cancer with impending obstruction.
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PMID:Hidden-loop colostomy. 64 1

Three patients presented an unilateral whitish cloudiness of the corneal epithelium which reduced the vision considerably. In two cases, radiotherapy was carried out previously (because of pterygium and because of teleangiectasia of the conjunctiva). In the eye of one patient, a superficial corneal lesion developed during general anesthesia. The corneal epithelium was scraped off in all cases, but the opacities reappeared. Histologically, the epithelium showed dyskeratosis with signs of malignancy. --7 illustrations (3 sketches of the corneas, 4 histological photographs).
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PMID:[Dyskeratosis of the corneal epithelium (author's transl)]. 65 Dec 25

Direct contact irradiation may be used in the curative treatment of patients with carefully selected early rectal lesions. With earlier diagnosis, a large number of patients may present with suitable lesions. The treatments last three minutes and are administered every two weeks to a total dose of 9,000 rad to 12,500 rad. The patients require no general anesthesia or hospitalization and may continue working during this treatment. There appears to be no risk of morbidity or mortality. The rectum is preserved. Most beneficial of all to the patient, a colostomy is avoided, although later surgery is not precluded for local failures. It has been found that recurrence, should it occur, appears within the 18 months immediately following treatment. Good palliation can be achieved in some cases for patients with metastatic disease, for their local symptoms. We believe that the endocavity method of irradiation contributes an important advance in the management of patients with cancer of the rectum and feel it should be available universally.
Cancer 1978 Sep
PMID:Treatment of rectal carcinomas by means of endocavity irradiation. 69 8

Our patients who are to undergo breast surgery are placed into one of four groups with a number of subdivisions. Each has a variable amount of preoperative work-up depending on the patient's age and constitutional status, the degree of suspicion as to the malignancy of the lesion, the type of anesthesia (local or general), the place where the biopsy is being done (in-patient or out-patient)and on the type of informed consent signed by the patient. Breast x-rays are used on a judicious and selective basis and thermography and ultrasound are used routinely.
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PMID:Preoperative work-up in breast surgery. 70 Sep 31

The origin, background, and mechanism of operation of the Maternal Mortality Study Committee in Wisconsin is outlined. Its value as a teaching vehicle is emphasized. Trends in maternal mortality in Wisconsin and the continued decline are presented, with 45 per 100,000 live births in 1953 to 9.2 per 100,000 live births in 1975. An appeal for standardization of terms and definitions and a continuation of these studies in each state is made. Study committees in many states are inactive. It is suggested that chairmen of maternal mortality committees in many states are inactive. It is suggested that chairmen of maternal mortality committees and representatives meet in geographic areas comparable to Districts of The American College of Obstetricians and Gynecologists to compare trends and statistics. Hemorrhage, once considered the important cause, has decreased from 56.4% of maternal loss to a low of 12.1% in 1975. Presently, a category listed as "other causes"--that is, other than hemorrhage, sepsis, and toxemia--account for approximately 60% of deaths. This group includes anesthesia, emboli and coincidental disease involving kidneys, heart, malignancy, and diabetes. An appeal is made to continue these studies.
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PMID:Mothers are still mortal. 70 97

We have tried to present a comprehensive survey of present-day management of hemorrhoids, fistulae and fissures, be it in the office or in the hospital. There is great socioeconomic pressure lately for cost-containment, which is apt to effect better medical judgment in the selection of type and place of management. Minor operations can and should be done, as always, on an outpatient basis. General anesthesia is not a minor matter and hemorrhoidectomy is not a minor operation. The major function of outpatient service in the management of anal disease is that of accurate and comprehensive diagnosis. Hundreds of patients come to us only because they fear cancer and it is not enough for us to hunt for and treat the vague little disorders of which they complain. The incidence of cancer of the colon rectum in this country just recently has slightly surpassed that of lung cancer. Adjuvant treatments (e.g., chemotherapy, radiotherapy, immunotherapy and their combinations) are promising but still in the investigational stage. Early diagnosis is our finest weapon with subsequent surgical management. The challenge and responsibility for early diagnosis of colorectal cancer is ours alone. We must first recognize it and then meet it firmly and squarely. We must feel for (digital rectal), look for (sigmoidoscopy), and search for (barium enema x-ray examination) colorectal cancer in all of our patients regardless of the insignificance of anal symptoms and anal findings. Our countrymen fear cancer. We have the devices to allay their fears or to cure their cancers if they are found early enough. We have a straightforward moral commitment and a national trust.
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PMID:Hemorrhoids, fistulae and fissures: office and hospital management--a critical review. 73 38

Cancer of the nose is very common and lesions seen by reconstructive surgeons are often recurrent and extensive. Surgical removal of cancer of the nasal skin can usually be accomplished under local anesthesia, and in most instances frozen section histologic examination should be used to confirm the adequacy of excision. The location and three dimensional extent of the tumor will dictate the choices of repair or reconstruction as well as the timing thereof. Very small lesions can be excised with primary closure; other well circumscribed tumors can be excised and the defect closed with an appropriate nasal flap. In our experience most nasal skin cancers have been managed by excision and full-thickness skin grafting. We have found the skin of the neck and that of the preauricular region to provide the best skin cover except in the upper third of the nose where upper eyelid skin provides excellent coverage. We have used composite grafts from the ear to replace up to two-thirds of an alar rim. Nasolabial, cheek, and midline forehead flaps are useful in a variety of instances, but usually when less than one-half of the nose has been excised. We have been pleased, in most instances, with the Converse scalping flap for near total, subtotal, and extensive three-dimensional lower nasal defects. (Transverse superficial temporal artery pedicle flaps can be successfully used to reconstruct large nasal defects with adjacent cheek loss.) We have rarely used distant flaps. Regardless of what regional pedicle flap has been transferred to the nose, subsequent revisions of a relatively minor nature will nearly always enhance the result. Patients who have undergone extended total nasectomies are probably best managed with a prosthesis, as prognosis is often guarded and flap reconstruction may be quite unsatisfactory. In our experience, defects in lining and support can usually be repaired with local nasal tissue.
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PMID:Cancer of the nose: ablation and repair. 78 30

A set of feedings of a lipid solution of 7,12-dimethylbenz(a)anthracene given biweekly by gastric intubation to young adult female mice of the non-inbred CF-1 strain elicited lymphatic leukemia in 73% of the animals in 112 +/- 24 days. Brief ether anesthesia facilitated alimentary administration of hydrocarbons and steroids. Inoculation of whole blood of mice with lymphatic leukemia into the subcutaneous tissue of allogeneic newborn resulted in lymphosarcomas at the injection site sometimes associated with leukemia. The lymphosarcomas of infant mice regressed rapidly following administration of cortisone or dexamethasone. They frequently, but not invariably, recurred; 14% of the mice were free from lymphosarcoma 3 months after treatment with the glucocorticoids.
Cancer 1976 Jan
PMID:Induction of lymphatic leukemia in non-inbred mice and its control with glucocorticoids. The Lucy Wortham James lecture. 81 25


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