Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0278126 (
loss of equilibrium
)
140
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The pathogenesis of
inflammatory bowel disease
(
IBD
) is due in part to a
loss of equilibrium
among the gut microbiota, epithelial cells, and resident immune cells. The gut microbiota contains a large proportion of probiotic commensal
Lactobacillus
species; some natural microbiota and probiotics confer protection against
IBD
. In this study, mice with colitis triggered by dextran sodium sulphate (DSS) were given
Lactobacillus plantarum
orally. We assessed the damage caused by DSS and the therapeutic activity of
L. plantarum
. The colitis triggered by DSS was less severe in the mice that received the
L. plantarum
treatment, which also diversified the microbe species in the colon, enhanced the ratio of Firmicutes to Bacteroidetes, and diminished the relative abundance of
Lactobacillus
. The taxonomic units of greatest diversity in the DSS and
L. plantarum
groups were identified using a linear discriminant and effect size (LEfSe) analysis.
Aliihoeflea
was established to be the genus of bacteria that was affected in the
L. plantarum
group most extensively. In conclusion, gut health was promoted by
L. plantarum
, as it diversified the microbes in the colon and restricted the activity of pathogenic bacteria in the intestine. Moreover, according to the LEfSe analysis, the DSS group was impacted more significantly by gut microorganisms than the
L. plantarum
group, suggesting that
L. plantarum
improved the stability of the intestinal tract.
...
PMID:The Impact of
Lactobacillus plantarum
on the Gut Microbiota of Mice with DSS-Induced Colitis. 3091 54
