UMLS:C0278080 - FACTA Search

Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0278080 (physical dependence)
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Human Gene/Protein
MPDZ protein	14.2
CNIH3	11.6
beta3 adrenoceptor	11.2
reticulon 1	11.1
Mu opioid receptor	10.1
DIPP	9.9
OXR1	9.8
phosducin-like	9.8
MPDZ	9.5
CGRP-receptor component protein	9.3
MOR-1	9.2
RGS4 protein	9.1
RTN1	8.8
HAO	8.8
mu opioid receptor	8.6
Neuropeptide FF	8.6
cerebellin	8.6
orexin receptor-1	8.5
AC7	8.5
L-glutaminase	8.4
NGD	8.4
EphB1	8.2
AC8	8.2
delta opioid receptor	8.0
Cav1.3	8.0
opioid receptor	7.8
guanine nucleotide-binding regulatory protein	7.8
P58	7.6
BDH	7.6
DHH	7.4
NPFF	7.4
leu5	7.4
B28	7.2
GluR5	7.2
Spn	7.2
Tic	7.2
KOR	7.1
IR1	7.1
Cav2.2	7.1
RGS7	7.1
PSD-93	7.1
OPRM1	7.1
extracellular signal-regulated kinase 5	7.0
SYM	6.9
TPL-2	6.9
NSA	6.9
arrestin 2	6.8
GRK6	6.8
prodynorphin	6.7
RGS9	6.7
WIN	6.7
P56	6.6
kappa opioid receptor	6.6
MAST	6.5
EphB2	6.5
GLT1	6.5
OGF	6.5
spinophilin	6.4
MC5R	6.4
PML protein	6.4
Met-enkephalin	6.4
12-LOX	6.4
apolipoprotein D	6.4
Leu5	6.4
dopamine D3 receptor	6.3
cystatin A	6.3
L-asparaginase	6.3
OX1R	6.3
bradykinin B2 receptor	6.3
OFQ	6.2
mu2	6.2
HOT	6.2
NR2B	6.1
nociceptin receptor	6.1
prostaglandin receptor	6.1
SCA2	6.1
PKC-gamma	6.1
mGlu1	6.1
aquaporin 4	6.1
FKBP51	6.1

Disease
physical dependence	14.2
Alcohol problem	13.2
Vagal bradycardia	11.6
morning drinking	11.5
cross-dependence	11.1
pathological intoxication	10.9
rapid reinstatement	10.9
Morphine dependence	10.7
narcotic dependence	10.5
alcohol hallucinosis	9.7
Opiates	9.0
Withdrawal syndrome	9.0
paranoid state	9.0
Opioid dependence	9.0
Primary insomnia	8.8
Subependymal giant cell astrocytoma	8.7
alcohol withdrawal syndrome	8.5
Substance dependence	8.4
polydrug abuse	8.3
suicidal ideas	8.3
Nicotine withdrawal	7.8
Chronic insomnia	7.8
tobacco dependence	7.8
heroin abuse	7.7
Dependence	7.6
anxiety neurosis	7.6
nicotine addiction	7.5
psychomotor impairment	7.5
marijuana abuse	7.5
kleptomania	7.3
drug withdrawal	7.2
drug addiction	7.1
delirium tremens	7.0
addiction	7.0
neonatal abstinence syndrome	7.0
Tic	6.8
heroin addiction	6.7
tranquilizers	6.5
alcoholism	6.3
dysphoria	6.3
hallucinosis	6.3
excessive drinking	6.1
SCA2	6.0
BED	6.0
audiogenic seizure	5.9
THC	5.9
drug abuse	5.9
chronic pain	5.7
hypersexuality	5.6
catalepsy	5.6
Pfeiffer	5.5
fits	5.4
prolapse	5.2
bone cancer	5.2
Cannabis	5.2
alcohol abuse	5.2
Abuse	5.2
TBS	5.1
cocaine addiction	5.1
compulsion	5.0
Habituation	5.0
drunk	4.9
petit mal	4.9
PCP	4.9
DBA	4.8
clinical depression	4.8
anguish	4.8
cocaine abuse	4.7
hypomania	4.6
tic	4.6
DWI	4.6
siderosis	4.6
GAD	4.5
substance abuse	4.5
heavy drinking	4.5
narcolepsy	4.5
RGS	4.4
trichotillomania	4.3
behavior disorder	4.3
anxiety disorders	4.3

Symptom
tonic seizure	8.1
physical symptom	7.3
cancer pain	6.9
muscle rigidity	6.7
retching	6.7
analgesia	6.7
impaired motor coordination	6.6
generalized pain	6.6
polydipsia	6.6
persistent cough	6.6
acute low back pain	6.1
acute pain	6.1
lassitude	6.1
incoordination	6.0
thirsty	5.9
constipation	5.8
intention tremor	5.8
Neuropathic pain	5.8
hyperacusis	5.7
hangover	5.7
tachypnea	5.7
prostration	5.7
tremor	5.6
breakthrough pain	5.5
loss of balance	5.4
blackout	5.4
hyperesthesia	5.2
insomnia	5.0
hypertonia	4.9
tonic-clonic seizure	4.9
Sedation	4.8
hypothermia	4.8
clonus	4.7
sleepiness	4.7
chronic back pain	4.7
dizziness	4.6
renal colic	4.6
ataxia	4.4
dysesthesia	4.3
agitation	4.3
twitching	4.2
seizures	4.2
catatonia	4.1
nausea	4.1
nasal congestion	4.1
diarrhea	4.1
decreased appetite	4.0
dental pain	4.0
asthenia	3.9
bitter taste	3.8
pain	3.7
vomiting	3.7
photophobia	3.6
nausea and vomiting	3.6
abdominal discomfort	3.5
hunger	3.3
sneezing	3.3
cough	3.1
anorexia	3.1
hopelessness	3.0
facial pain	3.0
dysuria	3.0
shortness of breath	2.9
sore throat	2.8
lethargy	2.8
bone pain	2.6
myalgia	2.5
dysarthria	2.3
apathy	2.2
myoclonus	2.2
paresthesia	2.0
low back pain	1.9
numbness	1.9
anesthesia	1.9
ENT	1.9
weakness	1.8
headache	1.8
cachexia	1.8
hypotonia	1.7
back pain	1.7

Enzyme
DIPP	9.8
PCP	5.8
asparaginase	5.4
glutaminase	4.9
CaMKII	4.8
monoacylglycerol lipase	4.8
carboxypeptidase A	4.3
GRK5	4.1
monoamine oxidase	3.8
demethylase	3.8
dopamine beta-hydroxylase	3.8
histidine decarboxylase	3.7
Alternating	3.6
aryl hydrocarbon hydroxylase	3.6
succinic dehydrogenase	3.5
tryptophan hydroxylase	3.4
prostaglandin synthetase	3.4
PAM	3.4
adenylate cyclase	3.3
glutamate decarboxylase	3.1
alcohol dehydrogenase	3.0
tyrosine hydroxylase	3.0
AMPK	3.0
PKG	2.9
CPR	2.9
MDP	2.8
5'-nucleotidase	2.6
protein kinase C	2.5
nitrate reductase	2.4
nitrate reductase	2.4
nitrate reductase	2.4
nitrate reductase	2.4
nitrate reductase	2.4
nitrate reductase	2.3
NADPH-diaphorase	2.3
MMP	2.2
lipoxygenase	2.1
acetylcholinesterase	2.0
phospholipase A2	2.0
protein kinase	1.9
NADPH oxidase	1.9
NO synthase	1.9
NQO1	1.6
succinate dehydrogenase	1.2
RNase	1.2
cdc2	1.2
calcineurin	1.2
RNase	1.1
MEK	1.1
CD10	1.0
mitogen-activated protein kinase	0.9
NADPH oxidase	0.8
cholinesterase	0.6
P-glycoprotein	0.5
ATPase	0.2
ACE	0.1
phosphodiesterase	0.0
creatine kinase	0.0
ERK	0.0
glutathione peroxidase	-0.2
ACS	-0.4
alanine aminotransferase	-0.5
lactate dehydrogenase	-0.6
reverse transcriptase	-0.7
alkaline phosphatase	-1.3
catalase	-1.5
peroxidase	-1.8