UMLS:C0278080 - FACTA Search

Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Target Concepts:

Query: UMLS:C0278080 (physical dependence)
1,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

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Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein
opioid receptor	135
Sep	108
GABA	50
Mol	32
NMDA receptor	31
mu opioid receptor	25
beta-endorphin	21
DBA	15
Gen	15
nitric oxide synthase	13
delta opioid receptor	12
5-hydroxytryptamine	12
PCP	11
calcium channel	11
CB1	11
dynorphin	10
NR2B	10
adenylate cyclase	10
adenylyl cyclase	9
GABA(A) receptor	9
substance P	9
WIN	9
CA1	9
calcitonin	8
tap	8
orexin	7
membrane-bound	7
L-type calcium channel	7
nicotinic acetylcholine receptor	7
tyrosine hydroxylase	7
glutamate receptor	7
THC	7
Met-enkephalin	6
cholecystokinin	6
interferon	6
microsomal	6
CAS	6
Leu5	6
calmodulin	6
vasopressin	6
neuronal nitric oxide synthase	6
CA3	6
L-asparaginase	6
cannabinoid receptor	6
cage	6
ICD	5
rat)	5
NR1	5
AMP	5
mouse)	5
cAMP-dependent protein kinase	5
Met	5
kappa opioid receptor	5
5-HT1A	5
acetylcholinesterase	5
polypeptide	5
CaMKII	5
OFQ	5
glutamate transporter	4
Tic	4
PKC	4
brain-derived neurotrophic factor	4
albumin	4
NR2A	4
neutral endopeptidase	4
DAF	4
prodynorphin	4
ERK1	4
bradykinin B2 receptor	4
MOR-1	4
endoplasmic reticulum	4
HT3	4
ATPase	4
alcohol dehydrogenase	4
ASP	3
cAMP response element-binding protein	3
TRH	3
MAPK	3
APA	3
peptidase	3

Disease
physical dependence	1658
addiction	193
depression	120
alcoholism	78
fits	68
chronic pain	53
drug addiction	45
drug abuse	29
prolapse	23
alcohol abuse	22
cancer	20
Dependence	18
drug withdrawal	18
anxiety disorders	16
substance abuse	16
Abuse	16
DBA	15
nicotine addiction	14
Opiates	12
PCP	11
alcohol withdrawal syndrome	10
cognitive impairment	10
confusion	10
psychosis	10
cold	9
tobacco dependence	9
schizophrenia	8
dysphoria	8
dementia	7
stroke	7
coma	7
hallucinations	7
THC	7
HIV	6
cirrhosis	6
substance use	6
catalepsy	6
NAME	6
Cannabis	6
violence	5
chronic disease	5
epilepsy	5
tranquilizers	5
virus infection	5
delirium tremens	5
drunk	5
aggression	5
posttraumatic stress disorder	5
herpes simplex	5
respiratory disease	5
delirium	5
ICD	5
diabetes	5
neuroblastoma	5
Tic	4
asthma	4
sexual dysfunction	4
amnesia	4
mental illness	4
migraine	4
cross-dependence	4
AIDS	4
tic	4
pertussis	4
gastroesophageal reflux disease	4
Morphine dependence	4
narcolepsy	3
CAM	3
West	3
fatty liver	3
SCH	3
clinical depression	3
xerostomia	3
GAD	3
GSH	3
obesity	3
hyperlipidemia	3
chronic obstructive pulmonary disease	3
heroin abuse	3
Evans	3

Symptom
pain	178
analgesia	152
seizures	78
diarrhea	50
tremor	47
constipation	30
hypothermia	25
nausea	21
anesthesia	21
vomiting	21
cancer pain	19
insomnia	18
ataxia	18
sleepiness	17
acute pain	14
agitation	12
dizziness	12
cough	11
polydipsia	11
headache	10
weakness	7
tachypnea	7
anorexia	6
nausea and vomiting	6
incoordination	6
muscle rigidity	6
fatigue	5
Neuropathic pain	4
tonic seizure	3
hunger	3
discomfort	3
discomfort	3
retching	3
persistent cough	3
myalgia	2
physical symptom	2
shortness of breath	2
tonic-clonic seizure	2
hypertonia	2
twitching	2
asthenia	2
Sedation	2
back pain	2
overweight	2
functional recovery	2
respiratory distress	2
lethargy	2
low back pain	2
apathy	1
cachexia	1
numbness	1
hyperesthesia	1
loss of balance	1
photophobia	1
lassitude	1
blackout	1
stigma	1
decreased appetite	1
chronic back pain	1
vertigo	1
impaired motor coordination	1
acute low back pain	1
dysarthria	1
acidity	1
hypotonia	1
breakthrough pain	1
abdominal pain	1
sneezing	1
thirsty	1
sore throat	1
catatonia	1
prostration	1
renal colic	1
starvation	1
dental pain	1
spasticity	1
chest pain	1
myoclonus	1
abdominal discomfort	1
hangover	1

Enzyme
protein kinase	16
protein kinase C	15
PCP	11
adenylate cyclase	10
mitogen-activated protein kinase	9
monoamine oxidase	8
tyrosine hydroxylase	6
CaMKII	6
acetylcholinesterase	6
asparaginase	6
AMPK	5
ERK	5
ATPase	4
demethylase	4
alcohol dehydrogenase	4
ACS	3
phospholipase A2	3
glutaminase	3
DIPP	3
NO synthase	3
NADPH oxidase	2
calcineurin	2
lipoxygenase	2
RNase	2
RNase	2
MEK	2
CPR	2
NQO1	1
5'-nucleotidase	1
NADPH-diaphorase	1
monoacylglycerol lipase	1
nitrate reductase	1
succinate dehydrogenase	1
creatine kinase	1
P-glycoprotein	1
PKG	1
phosphodiesterase	1
succinic dehydrogenase	1
catalase	1
MMP	1
tryptophan hydroxylase	1
GRK5	1
MDP	1
nitrate reductase	1
peroxidase	1
carboxypeptidase A	1
dopamine beta-hydroxylase	1
PAM	1
cdc2	1
nitrate reductase	1
glutathione peroxidase	1
glutamate decarboxylase	1
nitrate reductase	1
alanine aminotransferase	1
cholinesterase	1
lactate dehydrogenase	1
aryl hydrocarbon hydroxylase	1
histidine decarboxylase	1
NADPH oxidase	1
nitrate reductase	1
prostaglandin synthetase	1
CD10	1
reverse transcriptase	1
nitrate reductase	1
Alternating	1
ACE	1
alkaline phosphatase	1