Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278080 (physical dependence)
 1,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
opioid receptor 135
Sep 108
GABA 50
Mol 32
NMDA receptor 31
mu opioid receptor 25
beta-endorphin 21
Gen 15
DBA 15
nitric oxide synthase 13
5-hydroxytryptamine 12
delta opioid receptor 12
calcium channel 11
CB1 11
PCP 11
dynorphin 10
adenylate cyclase 10
NR2B 10
adenylyl cyclase 9
WIN 9
CA1 9
substance P 9
GABA(A) receptor 9
tap 8
calcitonin 8
orexin 7
THC 7
glutamate receptor 7
membrane-bound 7
L-type calcium channel 7
tyrosine hydroxylase 7
nicotinic acetylcholine receptor 7
CAS 6
cholecystokinin 6
vasopressin 6
interferon 6
calmodulin 6
cannabinoid receptor 6
cage 6
L-asparaginase 6
more...
Disease
physical dependence 1658
addiction 193
depression 120
alcoholism 78
fits 68
chronic pain 53
drug addiction 45
drug abuse 29
prolapse 23
alcohol abuse 22
cancer 20
Dependence 18
drug withdrawal 18
substance abuse 16
Abuse 16
anxiety disorders 16
DBA 15
nicotine addiction 14
Opiates 12
PCP 11
alcohol withdrawal syndrome 10
confusion 10
psychosis 10
cognitive impairment 10
cold 9
tobacco dependence 9
schizophrenia 8
dysphoria 8
coma 7
dementia 7
stroke 7
THC 7
hallucinations 7
cirrhosis 6
NAME 6
HIV 6
Cannabis 6
catalepsy 6
substance use 6
aggression 5
more...
Symptom
pain 178
analgesia 152
seizures 78
diarrhea 50
tremor 47
constipation 30
hypothermia 25
vomiting 21
nausea 21
anesthesia 21
cancer pain 19
ataxia 18
insomnia 18
sleepiness 17
acute pain 14
dizziness 12
agitation 12
cough 11
polydipsia 11
headache 10
tachypnea 7
weakness 7
incoordination 6
nausea and vomiting 6
muscle rigidity 6
anorexia 6
fatigue 5
Neuropathic pain 4
tonic seizure 3
hunger 3
persistent cough 3
discomfort 3
retching 3
discomfort 3
myalgia 2
physical symptom 2
shortness of breath 2
respiratory distress 2
asthenia 2
tonic-clonic seizure 2
more...
Drug
Ethanol 36
caffeine 15
PCP 11
Butorphanol 11
9-THC 5
ICI 5
Fentanyl 5
Clonidine 5
CTX 4
CSF 3
Tianeptine 3
ascorbate 3
CDP 3
Brotizolam 2
CAM 2
Zomepirac sodium 2
Buspar 2
Tapentadol 2
Bretazenil 2
Subutex 2
Halazepam 2
NADH 2
Buspar 2
Nephron 2
lactose 2
LAAM 2
Diurnal 1
Aprepitant 1
Rimonabant 1
Glutathione 1
GVG 1
Phenytoin 1
Flupirtine maleate 1
Triazolam 1
CTX 1
DPA 1
ROC 1
citric acid 1
Uncaria hook 1
Ritanserin 1
more...
Enzyme
protein kinase 16
protein kinase C 15
PCP 11
adenylate cyclase 10
mitogen-activated protein kinase 9
monoamine oxidase 8
tyrosine hydroxylase 6
asparaginase 6
CaMKII 6
acetylcholinesterase 6
ERK 5
AMPK 5
ATPase 4
alcohol dehydrogenase 4
demethylase 4
phospholipase A2 3
ACS 3
NO synthase 3
glutaminase 3
DIPP 3
calcineurin 2
lipoxygenase 2
CPR 2
RNase 2
RNase 2
MEK 2
NADPH oxidase 2
nitrate reductase 1
monoacylglycerol lipase 1
nitrate reductase 1
succinate dehydrogenase 1
creatine kinase 1
P-glycoprotein 1
PKG 1
catalase 1
phosphodiesterase 1
MDP 1
nitrate reductase 1
peroxidase 1
carboxypeptidase A 1
more...
Compound
ethanol 327
Dec 119
Morphine 98
water 83
Clin 75
Naloxone 65
GABA 50
GABA 50
calcium 36
glutamate 31
sulfate 30
cAMP 30
tyrosine 27
Phe 23
sodium 22
Gly 21
gamma-aminobutyric acid 20
noradrenaline 19
NMDA 18
arginine 17
Buprenorphine 17
Nicotine 16
caffeine 16
leucine 16
DBA 15
DBA 15
DBA 15
methionine 12
Diazepam 11
DNA 11
5-HT 11
PCP 11
glucose 11
DSM 10
acetic acid 10
Butorphanol 10
nitric oxide 9
NIDA 9
aspartic acid 9
Risperidone 9
more...