Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278080 (physical dependence)
 1,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
opioid receptor 135
Sep 108
GABA 50
Mol 32
NMDA receptor 31
mu opioid receptor 25
beta-endorphin 21
DBA 15
Gen 15
nitric oxide synthase 13
delta opioid receptor 12
5-hydroxytryptamine 12
PCP 11
CB1 11
calcium channel 11
adenylate cyclase 10
dynorphin 10
NR2B 10
CA1 9
substance P 9
GABA(A) receptor 9
adenylyl cyclase 9
WIN 9
tap 8
calcitonin 8
glutamate receptor 7
THC 7
tyrosine hydroxylase 7
orexin 7
nicotinic acetylcholine receptor 7
membrane-bound 7
L-type calcium channel 7
neuronal nitric oxide synthase 6
CA3 6
L-asparaginase 6
cannabinoid receptor 6
cholecystokinin 6
microsomal 6
interferon 6
Leu5 6
cage 6
Met-enkephalin 6
CAS 6
vasopressin 6
calmodulin 6
5-HT1A 5
CaMKII 5
cAMP-dependent protein kinase 5
polypeptide 5
acetylcholinesterase 5
ICD 5
OFQ 5
rat) 5
AMP 5
NR1 5
mouse) 5
kappa opioid receptor 5
Met 5
Tic 4
MOR-1 4
prodynorphin 4
brain-derived neurotrophic factor 4
albumin 4
glutamate transporter 4
ATPase 4
PKC 4
DAF 4
NR2A 4
endoplasmic reticulum 4
neutral endopeptidase 4
ERK1 4
bradykinin B2 receptor 4
HT3 4
alcohol dehydrogenase 4
ATP 3
APA 3
OPRM1 3
Leu-enkephalin 3
olfactory 3
Pol 3
CSF 3
corticotropin-releasing factor 3
cAMP response element binding protein 3
MIF 3
Neuropeptide FF 3
ERK 3
peptidase 3
G protein-coupled receptor 3
thymus 3
ionotropic 3
REM 3
SCH 3
c-fos 3
MAPK 3
JAMA 3
Orexin 3
Mu opioid receptor 3
GluR5 3
TRH 3
reserved 3
muscarinic receptor 3
CCK 3
cAMP response element-binding protein 3
brain protein 3
GTP 3
chloride channel 3
Cad 3
beta 1 3
GSH 3
ASP 3
DIPP 3
arrestin 3
KOR 3
ACS 3
ANA 3
OXR1 2
JNK 2
dopamine D2 receptor 2
dopamine D1 receptor 2
cytochrome P-450 2
reductase 2
Cav1.3 2
adrenocorticotropic hormone 2
CPA 2
cytochrome b5 2
cytokine 2
GLT-1 2
oxytocin 2
phospholipase A2 2
arginine vasopressin 2
CAM 2
sigma receptor 2
galanin 2
lymphoid 2
CDP 2
EphB1 2
MEK 2
GLT1 2
PLA 2
guanine nucleotide-binding regulatory protein 2
SAR 2
mu2 2
gut 2
tumor necrosis factor 2
PSD-95 2
Iba1 2
fatty acid amide hydrolase 2
ARC 2
AC8 2
RNase 2
lipoxygenase 2
CB2 2
COX-2 2
dopamine D3 receptor 2
glutaminase 2
proenkephalin 2
p38 2
mitogen-activated protein 2
IR1 2
interleukin-2 2
MOP 2
protein phosphatase 2
EphB2 2
serotonin transporter 2
CO2 2
VIII 2
IFN 2
NMR 2
aquaporin 4 2
GTPase 2
neurotensin 2
CHA 2
interleukin-6 2
castor 2
CREB 2
dimeric 2
interleukin-4 2
MAST 2
extracellular signal-regulated kinase 2
prolactin 2
NADH 2
arrestin 2 2
NMDA receptor subunit 2
antioxidant enzyme 2
PKA 1
nociceptin receptor 1
NQO1 1
HOS 1
ornithine transcarbamylase 1
TLR4 1
extracellular signal-regulated kinase 1 1
guanine nucleotide-binding protein 1
casein 1
FKBP51 1
Gsalpha 1
LAO 1
MC5R 1
reticulon 1 1
EP2 1
ACTH 1
proton pump 1
5-HT2A 1
SCA2 1
IL-1 1
orexin receptor-1 1
leu5 1
VEGF-B 1
alanine aminotransferase 1
monocyte chemotactic protein 1 1
LSD 1
alpha1-acid glycoprotein 1
interleukin 1 beta 1
all-trans 1
GAD 1
p75 1
heme oxygenase-1 1
endothelin-1 1
cytochrome P450 1
MC3 1
TIP 1
PKG 1
histamine H1 receptor 1
MPDZ 1
cyclooxygenase 1
GRK6 1
somatostatin 1
histidine decarboxylase 1
TOF 1
MPDZ protein 1
calmodulin-dependent protein kinase IV 1
4E-BP1 1
CCM 1
neurotrophic factor 1
D2 dopamine receptor 1
L-glutaminase 1
CBT 1
guanine nucleotide binding protein 1
methyltransferase 1
PCA 1
gamma2 1
phosphoprotein 1
Cav2.1 1
EP1 1
DHH 1
mTOR 1
LHRH 1
aminopeptidase 1
ADM 1
mGlu5 1
monoacylglycerol lipase 1
5-lipoxygenase 1
OGF 1
RGS2 1
P38 1
dopamine beta-hydroxylase 1
pleiotrophin 1
CGRP-receptor component protein 1
EXT 1
P56 1
CCL21 1
ATF6 1
CREB-binding protein 1
PAG 1
CNIH3 1
NPFF 1
GPI 1
SYM 1
CCK-B 1
GluR6 1
neurotrophin 1
growth hormone 1
NSA 1
GDP 1
glutathione peroxidase 1
Neuropeptide Y 1
gastrin 1
alternatively spliced 1
MMP 1
novel gene 1
period 2 1
C-reactive protein 1
cerebellin 1
protein kinase C inhibitor 1
apelin 1
lipopolysaccharide 1
phosducin-like 1
TPL-2 1
CA2 1
unknown function 1
OX1R 1
BDH 1
ERK2 1
B12 1
Net 1
prostaglandin receptor 1
ENT 1
histone 1
bradykinin 1
IL-1 beta 1
DMH 1
non-functional 1
THP 1
Cytochrome P-450 1
Mal 1
apolipoprotein D 1
interacting protein 1
TBS 1
GTP-binding protein 1
cystatin A 1
cAMP-response element 1
IL-6 1
mGlu1 1
MRI 1
Midkine 1
CTX 1
CBR 1
RTN1 1
transporter associated with antigen processing 1
dream 1
manganese superoxide dismutase 1
more...
Disease
physical dependence 1658
addiction 193
depression 120
alcoholism 78
fits 68
chronic pain 53
drug addiction 45
drug abuse 29
prolapse 23
alcohol abuse 22
cancer 20
drug withdrawal 18
Dependence 18
anxiety disorders 16
substance abuse 16
Abuse 16
DBA 15
nicotine addiction 14
Opiates 12
PCP 11
cognitive impairment 10
psychosis 10
confusion 10
alcohol withdrawal syndrome 10
tobacco dependence 9
cold 9
schizophrenia 8
dysphoria 8
hallucinations 7
THC 7
stroke 7
coma 7
dementia 7
HIV 6
catalepsy 6
cirrhosis 6
Cannabis 6
NAME 6
substance use 6
tranquilizers 5
violence 5
virus infection 5
herpes simplex 5
posttraumatic stress disorder 5
aggression 5
diabetes 5
chronic disease 5
ICD 5
delirium 5
delirium tremens 5
drunk 5
respiratory disease 5
epilepsy 5
neuroblastoma 5
Tic 4
amnesia 4
mental illness 4
Morphine dependence 4
migraine 4
gastroesophageal reflux disease 4
cross-dependence 4
AIDS 4
sexual dysfunction 4
asthma 4
pertussis 4
tic 4
heroin addiction 3
neuropathy 3
West 3
CAM 3
fatty liver 3
clinical depression 3
heavy drinking 3
heroin abuse 3
malnutrition 3
obesity 3
pruritus 3
hyperlipidemia 3
immunodeficiency 3
xerostomia 3
GAD 3
SCH 3
chronic obstructive pulmonary disease 3
Evans 3
narcolepsy 3
suicide 3
lung cancer 3
GSH 3
tumor 3
narcotic dependence 3
panic disorder 3
liver fibrosis 2
vascular disease 2
proptosis 2
binge eating 2
morning drinking 2
SAR 2
liver disease 2
excessive drinking 2
encephalopathy 2
compulsion 2
akinesia 2
cocaine addiction 2
nystagmus 2
bone cancer 2
obsessive-compulsive disorder 2
cholera 2
cholestasis 2
psychomotor impairment 2
suicidal ideas 2
substance use disorders 2
osteoporosis 2
disinhibition 2
borderline personality disorder 2
Opioid dependence 2
emphysema 2
polydrug abuse 2
dehydration 2
tuberculosis 2
alcohol use disorder 2
anxiety neurosis 2
hepatic encephalopathy 2
affective disorder 2
cocaine abuse 2
sleep disorders 2
sympathomimetic 2
tetraplegia 2
sinusitis 2
neonatal abstinence syndrome 2
Alzheimer's disease 2
Best 2
peripheral neuropathy 2
hypertension 2
glioma 2
cataplexy 1
RSV infection 1
Nicotine withdrawal 1
Poland 1
herpes zoster 1
parkinsonism 1
acute promyelocytic leukemia 1
sleep disturbances 1
Neuroblastoma 1
anguish 1
DWI 1
Habituation 1
Dementia with Lewy bodies 1
celiac disease 1
bruxism 1
vasculitis 1
Duchenne muscular dystrophy 1
CNS diseases 1
Edwards 1
duodenal ulcer 1
ischemia 1
MICA 1
hypochondriasis 1
metabolic disorder 1
hypoglycemia 1
fecal incontinence 1
Dissociation 1
audiogenic seizure 1
phenylketonuria 1
PTP 1
Tourette syndrome 1
trichotillomania 1
eating disorder 1
sickle cell disease 1
priapism 1
Primary insomnia 1
HSS 1
TBS 1
osteoarthritis 1
stereotypies 1
social phobia 1
Fabry 1
FAS 1
developmental disabilities 1
alcohol hallucinosis 1
PML 1
Vagal bradycardia 1
galactorrhea 1
strabismus 1
anhedonia 1
hyperglycemia 1
Frey 1
Pfeiffer 1
mania 1
antisocial behavior 1
multiple sclerosis 1
ovarian cancer 1
kleptomania 1
diabetic neuropathy 1
sexual assault 1
encephalitis 1
behavior disorder 1
SCA2 1
Ludwig 1
psychopathy 1
Substance dependence 1
Withdrawal syndrome 1
fear and anxiety 1
neuroticism 1
suicide attempts 1
Gaucher disease 1
aphasia 1
agoraphobia 1
hallucinosis 1
marijuana abuse 1
chronic bronchitis 1
carcinogenesis 1
blindness 1
oral cancer 1
hypomania 1
galactorrhea 1
incontinence 1
memory impairment 1
renal impairment 1
panic attacks 1
Syndrome 1
Neuroblastoma 1
incontinence 1
myocardial infarction 1
stress incontinence 1
ash 1
pathological intoxication 1
arthritis 1
siderosis 1
Chronic insomnia 1
paraplegia 1
HOS 1
Subependymal giant cell astrocytoma 1
Leigh syndrome 1
hepatitis 1
paranoid state 1
hepatitis B 1
BED 1
tumor growth 1
CTX 1
PAM 1
delusions 1
pneumonia 1
social stress 1
hyperphagia 1
hepatorenal syndrome 1
pyuria 1
tumorigenesis 1
senile dementia 1
petit mal 1
cardiovascular disease 1
lysosomal storage disease 1
RGS 1
erythroleukemia 1
bladder cancer 1
glaucoma 1
infectious diseases 1
rare disease 1
rheumatism 1
rapid reinstatement 1
glioblastoma 1
pancreatitis 1
photosensitivity 1
PCA 1
hypersexuality 1
Alcohol problem 1
Symptom
pain 178
analgesia 152
seizures 78
diarrhea 50
tremor 47
constipation 30
hypothermia 25
vomiting 21
anesthesia 21
nausea 21
cancer pain 19
insomnia 18
ataxia 18
sleepiness 17
acute pain 14
agitation 12
dizziness 12
polydipsia 11
cough 11
headache 10
tachypnea 7
weakness 7
anorexia 6
nausea and vomiting 6
muscle rigidity 6
incoordination 6
fatigue 5
Neuropathic pain 4
retching 3
hunger 3
persistent cough 3
tonic seizure 3
discomfort 3
discomfort 3
myalgia 2
physical symptom 2
shortness of breath 2
overweight 2
functional recovery 2
asthenia 2
hypertonia 2
twitching 2
back pain 2
tonic-clonic seizure 2
respiratory distress 2
Sedation 2
lethargy 2
low back pain 2
apathy 1
cachexia 1
numbness 1
hyperesthesia 1
loss of balance 1
photophobia 1
lassitude 1
blackout 1
stigma 1
decreased appetite 1
chronic back pain 1
vertigo 1
impaired motor coordination 1
acute low back pain 1
ENT 1
dyspnea 1
dystonia 1
sore throat 1
catatonia 1
hypotonia 1
dysuria 1
breakthrough pain 1
paresthesia 1
abdominal pain 1
sneezing 1
hopelessness 1
facial pain 1
hyperacusis 1
dysarthria 1
acidity 1
prostration 1
renal colic 1
starvation 1
dental pain 1
spasticity 1
intention tremor 1
thirsty 1
chest pain 1
myoclonus 1
abdominal discomfort 1
hangover 1
bone pain 1
nasal congestion 1
erythema 1
generalized pain 1
bitter taste 1
spasm 1
dysesthesia 1
clonus 1
Drug
Ethanol 36
caffeine 15
PCP 11
Butorphanol 11
Fentanyl 5
ICI 5
9-THC 5
Clonidine 5
CTX 4
CSF 3
ascorbate 3
Tianeptine 3
CDP 3
Zomepirac sodium 2
Subutex 2
CAM 2
Buspar 2
Brotizolam 2
Bretazenil 2
Nephron 2
NADH 2
Buspar 2
Tapentadol 2
Halazepam 2
lactose 2
LAAM 2
Rimonabant 1
Abecarnil 1
Magnolia bark 1
Zonisamide 1
Phenytoin 1
Flupirtine maleate 1
Theophylline 1
Triazolam 1
CTX 1
Ramelteon 1
Diphenhydramine 1
DPA 1
ROC 1
Tween 40 1
nitroglycerin 1
Morphine sulfate 1
Codeine 1
Narcan 1
Flunitrazepam 1
Leaf 1
Compound 18 1
Hydrocodone bitartrate 1
p75 1
Biopolymers 1
Spectrum 1
HCH 1
Codeine 1
Dakar 1
7-Nitroindazole 1
DHT 1
Ringer's solution 1
ENT 1
Aprepitant 1
Diurnal 1
Proglumide 1
Pitressin 1
Papaverine 1
Glutathione 1
DHT 1
GVG 1
CTX 1
Gabapentin 1
IL-2 1
Ketorolac tromethamine 1
Alpidem 1
citric acid 1
Adenosine triphosphate 1
Xyrem 1
Ritanserin 1
Uncaria hook 1
Photofrin 1
CET 1
Ouabain 1
Tuareg 1
Ketorolac 1
ETS 1
DFP 1
Phosphoramidon 1
Phentolamine 1
ADM 1
Propofol 1
Glycyrrhiza 1
Enzyme
protein kinase 16
protein kinase C 15
PCP 11
adenylate cyclase 10
mitogen-activated protein kinase 9
monoamine oxidase 8
tyrosine hydroxylase 6
CaMKII 6
acetylcholinesterase 6
asparaginase 6
AMPK 5
ERK 5
ATPase 4
demethylase 4
alcohol dehydrogenase 4
ACS 3
phospholipase A2 3
glutaminase 3
DIPP 3
NO synthase 3
NADPH oxidase 2
calcineurin 2
lipoxygenase 2
RNase 2
RNase 2
MEK 2
CPR 2
NQO1 1
5'-nucleotidase 1
NADPH-diaphorase 1
monoacylglycerol lipase 1
nitrate reductase 1
succinate dehydrogenase 1
creatine kinase 1
P-glycoprotein 1
PKG 1
phosphodiesterase 1
succinic dehydrogenase 1
catalase 1
MMP 1
tryptophan hydroxylase 1
GRK5 1
MDP 1
nitrate reductase 1
peroxidase 1
carboxypeptidase A 1
dopamine beta-hydroxylase 1
PAM 1
cdc2 1
nitrate reductase 1
glutathione peroxidase 1
glutamate decarboxylase 1
nitrate reductase 1
alanine aminotransferase 1
cholinesterase 1
lactate dehydrogenase 1
aryl hydrocarbon hydroxylase 1
histidine decarboxylase 1
NADPH oxidase 1
nitrate reductase 1
prostaglandin synthetase 1
CD10 1
reverse transcriptase 1
nitrate reductase 1
Alternating 1
ACE 1
alkaline phosphatase 1
Compound
ethanol 327
Dec 119
Morphine 98
water 83
Clin 75
Naloxone 65
GABA 50
GABA 50
calcium 36
glutamate 31
cAMP 30
sulfate 30
tyrosine 27
Phe 23
sodium 22
Gly 21
gamma-aminobutyric acid 20
noradrenaline 19
NMDA 18
Buprenorphine 17
arginine 17
leucine 16
Nicotine 16
caffeine 16
DBA 15
DBA 15
DBA 15
methionine 12
glucose 11
5-HT 11
PCP 11
Diazepam 11
DNA 11
Butorphanol 10
DSM 10
acetic acid 10
aspartic acid 9
HCl 9
Naltrexone 9
Risperidone 9
NH2 9
nitric oxide 9
NIDA 9
Methadone 8
Buspirone 8
aldehyde 8
piperazine 6
Heroin 6
DAMGO 6
D-Ala 6
Zolpidem 6
Cocaine 6
threonine 6
galactose 6
AMP 6
Flumazenil 6
acetaldehyde 6
oxygen 5
Asp 5
4-chlorophenyl 5
Midazolam 5
AMPA 5
ICI 5
4-chlorophenyl 5
Tramadol 5
phosphate 5
nitrogen 4
hydroxyindoleacetic acid 4
CTX 4
2,4-dichlorophenyl 4
alcohol dehydrogenase 4
aspartic acid 4
1H-pyrazole 4
2,4-dichlorophenyl 4
GSH 4
Prone 4
GSH 4
aspartic acid 4
aspartic acid 4
zinc 4
1H-pyrazole 4
His 4
Salt 4
TRH 4
aldehyde 4
1-methyl-4-piperidinol 3
Pentobarbital 3
Agmatine 3
ANA 3
ACS 3
propionic acid 3
MK801 3
iron 3
tryptophan 3
Baclofen 3
GTP 3
AEA 3
Glutamate 3
ANA 3
alanine 3
CPA 3
2-methylpiperazine 3
Veronal 3
GM1 3
ACS 3
potassium 3
tryptophan 3
Alprazolam 3
tryptophan 3
cyclopentyl 3
propionic acid 3
tryptophan 3
ATP 3
urea 3
Pentobarbital 3
CAM 2
propylene glycol 2
acetamide 2
pyridazine 2
1,1,1-trichloroethane 2
piperidine 2
glutamine 2
TSH 2
cGMP 2
Norepinephrine 2
Ceftriaxone 2
lysine 2
nicotinamide 2
hydrogen 2
aniline 2
gamma-hydroxybutyric acid 2
Ketamine 2
MEK 2
toluene 2
Nalorphine 2
pyridazine 2
PGE2 2
Pargyline 2
salt 2
DOPAC 2
dipropyl 2
CDP 2
SR 141716 2
Propranolol 2
A101 2
Nalbuphine 2
serine 2
Propranolol 2
MOP 2
APAP 2
Hydromorphone 2
Dopamine 2
Levallorphan 2
prostaglandin E1 2
CO2 2
acetate 2
Oxycodone 2
cinnamyl 2
piperidine 2
Paroxetine 2
Methamphetamine 2
Nifedipine 2
CPA 2
NOP 2
NADH 2
AEA 2
acetamide 2
Sodium 2
HVA 2
PNU 2
CPA 2
R 2 2
Nitrendipine 2
Barbiturate 2
ACTH 2
vinyl 2
CPA 2
cyanide 2
propylene glycol 1
PAG 1
quinoline 1
Cardiol 1
alpha-MSH 1
Luminal 1
cyclohexane 1
Alfentanil 1
Loperamide 1
CNA 1
Hydrocodone 1
Chloral hydrate 1
formic acid 1
MMC 1
DPH 1
methylhistamine 1
Thebaine 1
Sucrose 1
Venlafaxine 1
EAA 1
Adrenal 1
hydroxide 1
delta8-THC 1
glycerol 1
Vitamin D 1
formic acid 1
heptyl 1
cyclohexanecarboxamide 1
X 13 1
NPA 1
MHPG 1
TOF 1
TIF 1
Cholesterol 1
Pimozide 1
L-carnitine 1
Temazepam 1
Aniracetam 1
Honokiol 1
valine 1
Ethylketocyclazocine 1
Mepyramine 1
N2O 1
Spiperone 1
Codeine 1
Methionine 1
heptyl 1
2-butenyl 1
Caryophyllene 1
Oxazepam 1
Austin 1
DuP 697 1
LSD 1
acetyl-CoA 1
DIDS 1
CAT 1
Mequitazine 1
DFO 1
Mecamylamine 1
Taurine 1
ammonia 1
glutamic acid 1
THP 1
5-hydroxytryptophan 1
BDH 1
ACh 1
formic acid 1
Dynorphin 1
isoleucine 1
TNF 1
Phosphoramidon 1
Ouabain 1
Amphetamine 1
Choline 1
ornithine 1
1,1'-biphenyl 1
PGE 1
D-Histidine 1
formic acid 1
Sumatriptan 1
Endomorphin-1 1
Metiamide 1
PLA 1
VMA 1
retinoic acid 1
isoleucine 1
Pindolol 1
5-methylisoxazole 1
Sibutramine 1
Pentazocine 1
Ascorbic acid 1
Hexobarbital 1
cadmium 1
ornithine 1
Sinomenine 1
Serine 1
Metformin 1
formic acid 1
Sufentanil 1
quinoline 1
Mequitazine 1
Mequitazine 1
Nordihydroguaiaretic acid 1
DLG 1
ecgonine methyl ester 1
butyric acid 1
Morphine sulfate 1
Doxepin 1
2-pyrrolidinone 1
DBH 1
Valproic acid 1
Amphetamine 1
6-Hydroxydopamine 1
formic acid 1
beta-alanine 1
Hexobarbital 1
Benzoylecgonine 1
ornithine 1
copper 1
Ketorolac 1
CPP 1
Nitrite 1
Nitrite 1
Allopregnanolone 1
aminomethyl 1
Allopregnanolone 1
d-Amphetamine 1
proline 1
C6H8O4 1
Nimodipine 1
Glycine, 1
Glycine, 1
ornithine 1
Metformin 1
CPP 1
Theophylline 1
ornithine 1
Cyclazocine 1
Propoxyphene 1
Nitrazepam 1
Yohimbine 1
Tranylcypromine 1
more...