Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278080 (physical dependence)
 1,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
opioid receptor 135
Sep 108
GABA 50
Mol 32
NMDA receptor 31
mu opioid receptor 25
beta-endorphin 21
Gen 15
DBA 15
nitric oxide synthase 13
delta opioid receptor 12
5-hydroxytryptamine 12
calcium channel 11
PCP 11
CB1 11
NR2B 10
dynorphin 10
adenylate cyclase 10
WIN 9
adenylyl cyclase 9
more...
Disease
physical dependence 1658
addiction 193
depression 120
alcoholism 78
fits 68
chronic pain 53
drug addiction 45
drug abuse 29
prolapse 23
alcohol abuse 22
cancer 20
Dependence 18
drug withdrawal 18
substance abuse 16
anxiety disorders 16
Abuse 16
DBA 15
nicotine addiction 14
Opiates 12
PCP 11
more...
Symptom
pain 178
analgesia 152
seizures 78
diarrhea 50
tremor 47
constipation 30
hypothermia 25
anesthesia 21
nausea 21
vomiting 21
cancer pain 19
insomnia 18
ataxia 18
sleepiness 17
acute pain 14
agitation 12
dizziness 12
cough 11
polydipsia 11
headache 10
more...
Drug
Ethanol 36
caffeine 15
PCP 11
Butorphanol 11
9-THC 5
ICI 5
Fentanyl 5
Clonidine 5
CTX 4
ascorbate 3
Tianeptine 3
CSF 3
CDP 3
Halazepam 2
Subutex 2
Nephron 2
CAM 2
Buspar 2
Brotizolam 2
lactose 2
more...
Enzyme
protein kinase 16
protein kinase C 15
PCP 11
adenylate cyclase 10
mitogen-activated protein kinase 9
monoamine oxidase 8
tyrosine hydroxylase 6
asparaginase 6
acetylcholinesterase 6
CaMKII 6
AMPK 5
ERK 5
ATPase 4
alcohol dehydrogenase 4
demethylase 4
DIPP 3
ACS 3
NO synthase 3
glutaminase 3
phospholipase A2 3
more...
Compound
ethanol 327
Dec 119
Morphine 98
water 83
Clin 75
Naloxone 65
GABA 50
GABA 50
calcium 36
glutamate 31
sulfate 30
cAMP 30
tyrosine 27
Phe 23
sodium 22
Gly 21
gamma-aminobutyric acid 20
noradrenaline 19
NMDA 18
arginine 17
more...