Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278080 (physical dependence)
 1,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
opioid receptor 0.001
MPDZ protein 0.001
mu opioid receptor 0.000
CNIH3 0.000
beta3 adrenoceptor 0.000
reticulon 1 0.000
Mu opioid receptor 0.000
DIPP 0.000
OXR1 0.000
delta opioid receptor 0.000
MOR-1 0.000
phosducin-like 0.000
MPDZ 0.000
CGRP-receptor component protein 0.000
RGS4 protein 0.000
Neuropeptide FF 0.000
HAO 0.000
RTN1 0.000
GABA 0.000
cerebellin 0.000
orexin receptor-1 0.000
AC7 0.000
L-glutaminase 0.000
EphB1 0.000
AC8 0.000
NGD 0.000
NMDA receptor 0.000
Cav1.3 0.000
WIN 0.000
guanine nucleotide-binding regulatory protein 0.000
Tic 0.000
NR2B 0.000
P58 0.000
GluR5 0.000
BDH 0.000
KOR 0.000
PCP 0.000
OPRM1 0.000
kappa opioid receptor 0.000
Met-enkephalin 0.000
Leu5 0.000
NPFF 0.000
DHH 0.000
prodynorphin 0.000
leu5 0.000
IR1 0.000
L-asparaginase 0.000
B28 0.000
Spn 0.000
CB1 0.000
dynorphin 0.000
Cav2.2 0.000
OFQ 0.000
RGS7 0.000
DBA 0.000
PSD-93 0.000
extracellular signal-regulated kinase 5 0.000
arrestin 2 0.000
SYM 0.000
bradykinin B2 receptor 0.000
TPL-2 0.000
NSA 0.000
L-type calcium channel 0.000
beta-endorphin 0.000
GRK6 0.000
RGS9 0.000
MAST 0.000
EphB2 0.000
GLT1 0.000
P56 0.000
dopamine D3 receptor 0.000
GABA(A) receptor 0.000
OGF 0.000
spinophilin 0.000
ASP 0.000
mu2 0.000
MC5R 0.000
brain protein 0.000
PML protein 0.000
12-LOX 0.000
orexin 0.000
apolipoprotein D 0.000
THC 0.000
cystatin A 0.000
OX1R 0.000
aquaporin 4 0.000
HOT 0.000
nociceptin receptor 0.000
prostaglandin receptor 0.000
NR1 0.000
SCA2 0.000
MIF 0.000
PKC-gamma 0.000
mGlu1 0.000
FKBP51 0.000
cannabinoid receptor 0.000
NR2A 0.000
HINT 0.000
CNA 0.000
chemokine receptor 2 0.000
RGS2 0.000
TIP 0.000
CaMKII 0.000
Orexin 0.000
VEGF-B 0.000
Win 0.000
NMDA receptor subunit 0.000
sigma receptor 0.000
cAMP response element binding protein 0.000
DAF 0.000
5-hydroxytryptamine 0.000
TRK 0.000
adenylyl cyclase 0.000
NSP 0.000
Cav2.1 0.000
FOG 0.000
D3R 0.000
AC1 0.000
neuronal nitric oxide synthase 0.000
regulator of G protein signaling 0.000
TIF 0.000
CAS 0.000
CBR 0.000
DREAM 0.000
neuronal nicotinic acetylcholine receptor 0.000
Gsalpha 0.000
CP47 0.000
LAO 0.000
glutamate transporter 0.000
HT3 0.000
CCK-B 0.000
cAMP response element-binding protein 0.000
RGS4 0.000
EPM 0.000
Leu-enkephalin 0.000
calcium channel 0.000
MOP 0.000
nicotinic acetylcholine receptor 0.000
DMH 0.000
mGlu5 0.000
MC1 0.000
Iba1 0.000
TBS 0.000
glutamate receptor 0.000
EXT 0.000
HAD 0.000
GluR6 0.000
fatty acid amide hydrolase 0.000
GLT-1 0.000
Midkine 0.000
proenkephalin 0.000
melanocortin-4 receptor 0.000
neutral endopeptidase 0.000
mouse) 0.000
PKC-beta 0.000
dopamine D1 receptor 0.000
CHA 0.000
calmodulin-dependent protein kinase IV 0.000
rat) 0.000
melanocortin receptor 0.000
more...
Disease
physical dependence 0.999
addiction 0.001
Alcohol problem 0.001
cross-dependence 0.000
morning drinking 0.000
Morphine dependence 0.000
Vagal bradycardia 0.000
narcotic dependence 0.000
Opiates 0.000
alcoholism 0.000
drug addiction 0.000
rapid reinstatement 0.000
pathological intoxication 0.000
alcohol withdrawal syndrome 0.000
Dependence 0.000
alcohol hallucinosis 0.000
drug withdrawal 0.000
nicotine addiction 0.000
fits 0.000
chronic pain 0.000
tobacco dependence 0.000
Opioid dependence 0.000
paranoid state 0.000
Withdrawal syndrome 0.000
drug abuse 0.000
Primary insomnia 0.000
Subependymal giant cell astrocytoma 0.000
depression 0.000
polydrug abuse 0.000
suicidal ideas 0.000
Substance dependence 0.000
heroin abuse 0.000
delirium tremens 0.000
prolapse 0.000
Nicotine withdrawal 0.000
alcohol abuse 0.000
Chronic insomnia 0.000
anxiety neurosis 0.000
dysphoria 0.000
psychomotor impairment 0.000
marijuana abuse 0.000
Tic 0.000
Abuse 0.000
tranquilizers 0.000
kleptomania 0.000
neonatal abstinence syndrome 0.000
heroin addiction 0.000
THC 0.000
DBA 0.000
substance abuse 0.000
PCP 0.000
catalepsy 0.000
anxiety disorders 0.000
hallucinosis 0.000
excessive drinking 0.000
Cannabis 0.000
SCA2 0.000
BED 0.000
audiogenic seizure 0.000
drunk 0.000
hypersexuality 0.000
Pfeiffer 0.000
bone cancer 0.000
hallucinations 0.000
tic 0.000
cocaine addiction 0.000
clinical depression 0.000
compulsion 0.000
TBS 0.000
Habituation 0.000
GAD 0.000
petit mal 0.000
heavy drinking 0.000
narcolepsy 0.000
cocaine abuse 0.000
delirium 0.000
sexual dysfunction 0.000
anguish 0.000
confusion 0.000
hypomania 0.000
DWI 0.000
siderosis 0.000
amnesia 0.000
RGS 0.000
trichotillomania 0.000
alcohol use disorder 0.000
behavior disorder 0.000
psychosis 0.000
coma 0.000
PTP 0.000
hypochondriasis 0.000
Ludwig 0.000
akinesia 0.000
pyuria 0.000
hepatorenal syndrome 0.000
ICD 0.000
galactorrhea 0.000
cataplexy 0.000
xerostomia 0.000
NAME 0.000
HOS 0.000
fear and anxiety 0.000
bruxism 0.000
stereotypies 0.000
substance use 0.000
cognitive impairment 0.000
respiratory disease 0.000
SCH 0.000
panic disorder 0.000
galactorrhea 0.000
tetraplegia 0.000
sympathomimetic 0.000
priapism 0.000
CAM 0.000
binge eating 0.000
HSS 0.000
Leigh syndrome 0.000
MICA 0.000
lysosomal storage disease 0.000
agoraphobia 0.000
senile dementia 0.000
Dementia with Lewy bodies 0.000
PAM 0.000
proptosis 0.000
substance use disorders 0.000
gastroesophageal reflux disease 0.000
borderline personality disorder 0.000
hepatic encephalopathy 0.000
antisocial behavior 0.000
chronic disease 0.000
posttraumatic stress disorder 0.000
disinhibition 0.000
RSV infection 0.000
Neuroblastoma 0.000
Neuroblastoma 0.000
fecal incontinence 0.000
social phobia 0.000
panic attacks 0.000
social stress 0.000
affective disorder 0.000
CNS diseases 0.000
Frey 0.000
anhedonia 0.000
sinusitis 0.000
migraine 0.000
rheumatism 0.000
schizophrenia 0.000
Gaucher disease 0.000
Evans 0.000
neuroblastoma 0.000
sleep disorders 0.000
herpes simplex 0.000
pertussis 0.000
Tourette syndrome 0.000
phenylketonuria 0.000
aggression 0.000
violence 0.000
nystagmus 0.000
SAR 0.000
sexual assault 0.000
more...
Symptom
analgesia 0.001
cancer pain 0.000
tremor 0.000
pain 0.000
constipation 0.000
seizures 0.000
tonic seizure 0.000
polydipsia 0.000
acute pain 0.000
muscle rigidity 0.000
diarrhea 0.000
hypothermia 0.000
physical symptom 0.000
insomnia 0.000
retching 0.000
incoordination 0.000
persistent cough 0.000
sleepiness 0.000
tachypnea 0.000
ataxia 0.000
nausea 0.000
impaired motor coordination 0.000
generalized pain 0.000
Neuropathic pain 0.000
dizziness 0.000
vomiting 0.000
acute low back pain 0.000
lassitude 0.000
agitation 0.000
thirsty 0.000
intention tremor 0.000
hyperacusis 0.000
hangover 0.000
prostration 0.000
breakthrough pain 0.000
loss of balance 0.000
blackout 0.000
hyperesthesia 0.000
hypertonia 0.000
tonic-clonic seizure 0.000
Sedation 0.000
cough 0.000
clonus 0.000
chronic back pain 0.000
nausea and vomiting 0.000
renal colic 0.000
twitching 0.000
anesthesia 0.000
dysesthesia 0.000
catatonia 0.000
anorexia 0.000
nasal congestion 0.000
decreased appetite 0.000
asthenia 0.000
dental pain 0.000
bitter taste 0.000
hunger 0.000
photophobia 0.000
abdominal discomfort 0.000
headache 0.000
sneezing 0.000
shortness of breath 0.000
hopelessness 0.000
facial pain 0.000
weakness 0.000
dysuria 0.000
lethargy 0.000
sore throat 0.000
myalgia 0.000
bone pain 0.000
dysarthria 0.000
apathy 0.000
myoclonus 0.000
low back pain 0.000
paresthesia 0.000
numbness 0.000
ENT 0.000
back pain 0.000
discomfort 0.000
cachexia 0.000
fatigue 0.000
hypotonia 0.000
functional recovery 0.000
discomfort 0.000
spasticity 0.000
vertigo 0.000
spasm 0.000
dystonia 0.000
respiratory distress 0.000
overweight 0.000
erythema 0.000
stigma 0.000
acidity 0.000
chest pain 0.000
starvation 0.000
dyspnea 0.000
abdominal pain 0.000
Drug
Halazepam 0.001
Butorphanol 0.000
Flupirtine maleate 0.000
Zomepirac sodium 0.000
Buspar 0.000
Hydrocodone bitartrate 0.000
Bretazenil 0.000
Buspar 0.000
Uncaria hook 0.000
Magnolia bark 0.000
Tuareg 0.000
Ethanol 0.000
Brotizolam 0.000
Xyrem 0.000
Subutex 0.000
Abecarnil 0.000
Tianeptine 0.000
Alpidem 0.000
LAAM 0.000
Tapentadol 0.000
Narcan 0.000
Ramelteon 0.000
7-Nitroindazole 0.000
PCP 0.000
Ketorolac tromethamine 0.000
Compound 18 0.000
Morphine sulfate 0.000
Proglumide 0.000
Fentanyl 0.000
Aprepitant 0.000
CET 0.000
GVG 0.000
Ritanserin 0.000
9-THC 0.000
Tween 40 0.000
Phosphoramidon 0.000
Clonidine 0.000
Triazolam 0.000
Pitressin 0.000
Ketorolac 0.000
Rimonabant 0.000
caffeine 0.000
Codeine 0.000
Flunitrazepam 0.000
Codeine 0.000
Zonisamide 0.000
Papaverine 0.000
CDP 0.000
ICI 0.000
Gabapentin 0.000
Adenosine triphosphate 0.000
Photofrin 0.000
DFP 0.000
Diphenhydramine 0.000
Phentolamine 0.000
DPA 0.000
Phenytoin 0.000
Glycyrrhiza 0.000
CTX 0.000
Diurnal 0.000
Theophylline 0.000
Propofol 0.000
Dakar 0.000
DHT 0.000
DHT 0.000
Ouabain 0.000
CAM 0.000
ETS 0.000
Ringer's solution 0.000
ADM 0.000
HCH 0.000
p75 0.000
Glutathione 0.000
CTX 0.000
CTX 0.000
ascorbate 0.000
lactose 0.000
CSF 0.000
ROC 0.000
Spectrum 0.000
Nephron 0.000
Biopolymers 0.000
ENT 0.000
nitroglycerin 0.000
NADH 0.000
citric acid 0.000
Leaf 0.000
IL-2 0.000
Enzyme
DIPP 0.000
PCP 0.000
asparaginase 0.000
CaMKII 0.000
glutaminase 0.000
monoamine oxidase 0.000
adenylate cyclase 0.000
monoacylglycerol lipase 0.000
protein kinase C 0.000
demethylase 0.000
carboxypeptidase A 0.000
protein kinase 0.000
GRK5 0.000
tyrosine hydroxylase 0.000
AMPK 0.000
dopamine beta-hydroxylase 0.000
histidine decarboxylase 0.000
alcohol dehydrogenase 0.000
Alternating 0.000
aryl hydrocarbon hydroxylase 0.000
succinic dehydrogenase 0.000
tryptophan hydroxylase 0.000
prostaglandin synthetase 0.000
PAM 0.000
glutamate decarboxylase 0.000
acetylcholinesterase 0.000
CPR 0.000
PKG 0.000
MDP 0.000
5'-nucleotidase 0.000
phospholipase A2 0.000
nitrate reductase 0.000
nitrate reductase 0.000
nitrate reductase 0.000
nitrate reductase 0.000
nitrate reductase 0.000
mitogen-activated protein kinase 0.000
nitrate reductase 0.000
lipoxygenase 0.000
NADPH-diaphorase 0.000
NO synthase 0.000
MMP 0.000
NADPH oxidase 0.000
NQO1 0.000
RNase 0.000
calcineurin 0.000
RNase 0.000
MEK 0.000
succinate dehydrogenase 0.000
cdc2 0.000
CD10 0.000
ATPase 0.000
ERK 0.000
NADPH oxidase 0.000
cholinesterase 0.000
P-glycoprotein 0.000
ACE 0.000
phosphodiesterase 0.000
creatine kinase 0.000
ACS 0.000
glutathione peroxidase 0.000
alanine aminotransferase 0.000
lactate dehydrogenase 0.000
reverse transcriptase 0.000
alkaline phosphatase 0.000
catalase 0.000
peroxidase 0.000
Compound
Morphine 0.001
1-methyl-4-piperidinol 0.001
Naloxone 0.001
ethanol 0.000
Butorphanol 0.000
Levallorphan 0.000
Buprenorphine 0.000
DuP 697 0.000
D-Histidine 0.000
Gelsemine 0.000
Buspirone 0.000
Thebaine 0.000
Nalorphine 0.000
D-Phenylalanine 0.000
Veronal 0.000
Zolpidem 0.000
Hydromorphone 0.000
SR 141716 0.000
Mequitazine 0.000
Mequitazine 0.000
Mequitazine 0.000
Mequitazine 0.000
Naltrexone 0.000
Flumazenil 0.000
4-piperidinol 0.000
C6H8O4 0.000
delta8-THC 0.000
Risperidone 0.000
Ethylketocyclazocine 0.000
Cyclazocine 0.000
Heroin 0.000
Hydrocodone 0.000
GABA 0.000
decahydroisoquinoline 0.000
GABA 0.000
Levorphanol 0.000
Propoxyphene 0.000
Bergenin 0.000
Prone 0.000
A101 0.000
Methadone 0.000
Benzoylecgonine 0.000
Nalbuphine 0.000
X 13 0.000
Tramadol 0.000
Aniracetam 0.000
Alprazolam 0.000
4-phenylpiperidine 0.000
Hexobarbital 0.000
Barbiturate 0.000
Pargyline 0.000
Tizanidine 0.000
2,4-dichlorophenyl 0.000
2,4-dichlorophenyl 0.000
Oleamide 0.000
Agmatine 0.000
Morphine sulfate 0.000
202-791 0.000
Cytisine 0.000
Doxepin 0.000
BDH 0.000
DHM 0.000
DAMGO 0.000
Endomorphin-1 0.000
Oxycodone 0.000
EEDQ 0.000
Guanabenz 0.000
PCP 0.000
Temazepam 0.000
Nicotine 0.000
Midazolam 0.000
DBA 0.000
gamma-aminobutyric acid 0.000
Metiamide 0.000
DBA 0.000
Tranylcypromine 0.000
Sinomenine 0.000
Hexobarbital 0.000
Caryophyllene 0.000
D-Ala 0.000
1H-pyrazole 0.000
Oxazepam 0.000
NOP 0.000
NMDA 0.000
Diazepam 0.000
DBA 0.000
Sufentanil 0.000
1H-pyrazole 0.000
Nitrendipine 0.000
2-methylpiperazine 0.000
Pentobarbital 0.000
Nitrazepam 0.000
Sibutramine 0.000
Pentazocine 0.000
Phosphoramidon 0.000
Paroxetine 0.000
TIF 0.000
Alfentanil 0.000
1,1,2-trichloroethane 0.000
cyclohexanecarboxamide 0.000
cAMP 0.000
Pentazocine 0.000
Saccharin 0.000
Ketorolac 0.000
Allopregnanolone 0.000
ecgonine methyl ester 0.000
Ephedrine 0.000
Chloral hydrate 0.000
DLG 0.000
NIDA 0.000
Gly 0.000
2-pyrrolidinone 0.000
glutamate 0.000
GYKI 52466 0.000
Allopregnanolone 0.000
gamma-hydroxybutyric acid 0.000
caffeine 0.000
Glycine, 0.000
Baclofen 0.000
Mecamylamine 0.000
Loperamide 0.000
PNU 0.000
4-chlorophenyl 0.000
4-chlorophenyl 0.000
Spiperone 0.000
Honokiol 0.000
MK801 0.000
2-butenyl 0.000
Mepyramine 0.000
1,1,1-trichloroethane 0.000
R 2 0.000
AEA 0.000
noradrenaline 0.000
Chlordiazepoxide 0.000
2-butenyl 0.000
6-Hydroxydopamine 0.000
Pimozide 0.000
Codeine 0.000
Cocaine 0.000
Remifentanil 0.000
Phe 0.000
Pentobarbital 0.000
AEA 0.000
pyridazine 0.000
pyridazine 0.000
Glycine, 0.000
Pindolol 0.000
water 0.000
EAA 0.000
CNA 0.000
Sumatriptan 0.000
THIP 0.000
Ceftriaxone 0.000
MOP 0.000
Lorazepam 0.000
Corticotropin 0.000
d-Amphetamine 0.000
piperazine 0.000
2-pyrrolidinone 0.000
cyclopentyl 0.000
more...