Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278080 (physical dependence)
 1,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MPDZ protein 14.2
CNIH3 11.6
beta3 adrenoceptor 11.2
reticulon 1 11.1
Mu opioid receptor 10.1
DIPP 9.9
OXR1 9.8
phosducin-like 9.8
MPDZ 9.5
CGRP-receptor component protein 9.3
MOR-1 9.2
RGS4 protein 9.1
HAO 8.8
RTN1 8.8
mu opioid receptor 8.6
Neuropeptide FF 8.6
cerebellin 8.6
orexin receptor-1 8.5
AC7 8.5
L-glutaminase 8.4
NGD 8.4
EphB1 8.2
AC8 8.2
delta opioid receptor 8.0
Cav1.3 8.0
opioid receptor 7.8
guanine nucleotide-binding regulatory protein 7.8
P58 7.6
BDH 7.6
NPFF 7.4
DHH 7.4
leu5 7.4
B28 7.2
GluR5 7.2
Spn 7.2
Tic 7.2
KOR 7.1
IR1 7.1
Cav2.2 7.1
RGS7 7.1
PSD-93 7.1
OPRM1 7.1
extracellular signal-regulated kinase 5 7.0
SYM 6.9
TPL-2 6.9
NSA 6.9
arrestin 2 6.8
GRK6 6.8
prodynorphin 6.7
RGS9 6.7
WIN 6.7
P56 6.6
kappa opioid receptor 6.6
MAST 6.5
EphB2 6.5
GLT1 6.5
OGF 6.5
spinophilin 6.4
MC5R 6.4
PML protein 6.4
Met-enkephalin 6.4
12-LOX 6.4
apolipoprotein D 6.4
Leu5 6.4
dopamine D3 receptor 6.3
cystatin A 6.3
L-asparaginase 6.3
OX1R 6.3
bradykinin B2 receptor 6.3
mu2 6.2
OFQ 6.2
HOT 6.2
NR2B 6.1
nociceptin receptor 6.1
prostaglandin receptor 6.1
SCA2 6.1
PKC-gamma 6.1
mGlu1 6.1
aquaporin 4 6.1
FKBP51 6.1
HINT 6.0
ASP 6.0
CNA 6.0
chemokine receptor 2 6.0
brain protein 6.0
RGS2 5.9
TIP 5.9
VEGF-B 5.9
Win 5.9
PCP 5.8
TRK 5.8
NSP 5.7
Cav2.1 5.7
FOG 5.7
D3R 5.7
AC1 5.7
NMDA receptor subunit 5.7
regulator of G protein signaling 5.7
TIF 5.7
sigma receptor 5.7
MIF 5.7
CBR 5.7
DREAM 5.6
L-type calcium channel 5.6
neuronal nicotinic acetylcholine receptor 5.6
Gsalpha 5.6
CP47 5.6
LAO 5.6
CCK-B 5.6
RGS4 5.5
EPM 5.5
dynorphin 5.5
Orexin 5.5
DMH 5.4
CB1 5.4
cAMP response element binding protein 5.4
mGlu5 5.4
MC1 5.4
NR2A 5.4
TBS 5.3
EXT 5.3
MOP 5.3
HAD 5.2
NR1 5.2
NMDA receptor 5.2
DAF 5.2
GluR6 5.2
Iba1 5.2
orexin 5.2
Midkine 5.2
THC 5.1
cAMP response element-binding protein 5.1
melanocortin-4 receptor 5.1
PKC-beta 5.1
Leu-enkephalin 5.1
CaMKII 5.1
calmodulin-dependent protein kinase IV 5.0
melanocortin receptor 5.0
cannabinoid receptor 5.0
fatty acid amide hydrolase 5.0
GLT-1 5.0
proenkephalin 5.0
GABA(A) receptor 5.0
DBA 5.0
PKI 5.0
Choline acetyltransferase 4.9
RGS 4.9
alpha1-acid glycoprotein 4.9
glutamate transporter 4.9
HT3 4.9
dopamine D1 receptor 4.9
CHA 4.9
MC3 4.9
p60 4.8
GABA 4.8
AP4 4.8
16a 4.8
monocyte chemotactic protein 1 4.8
guanine nucleotide binding protein 4.8
pleiotrophin 4.8
more...
Disease
physical dependence 14.2
Alcohol problem 13.2
Vagal bradycardia 11.6
morning drinking 11.5
cross-dependence 11.1
pathological intoxication 10.9
rapid reinstatement 10.9
Morphine dependence 10.7
narcotic dependence 10.5
alcohol hallucinosis 9.7
Opiates 9.0
Withdrawal syndrome 9.0
paranoid state 9.0
Opioid dependence 9.0
Primary insomnia 8.8
Subependymal giant cell astrocytoma 8.7
alcohol withdrawal syndrome 8.5
Substance dependence 8.4
polydrug abuse 8.3
suicidal ideas 8.3
Nicotine withdrawal 7.8
Chronic insomnia 7.8
tobacco dependence 7.8
heroin abuse 7.7
Dependence 7.6
anxiety neurosis 7.6
nicotine addiction 7.5
psychomotor impairment 7.5
marijuana abuse 7.5
kleptomania 7.3
drug withdrawal 7.2
drug addiction 7.1
delirium tremens 7.0
addiction 7.0
neonatal abstinence syndrome 7.0
Tic 6.8
heroin addiction 6.7
tranquilizers 6.5
alcoholism 6.3
dysphoria 6.3
hallucinosis 6.3
excessive drinking 6.1
SCA2 6.0
BED 6.0
audiogenic seizure 5.9
THC 5.9
drug abuse 5.9
chronic pain 5.7
hypersexuality 5.6
catalepsy 5.6
Pfeiffer 5.5
fits 5.4
prolapse 5.2
bone cancer 5.2
Cannabis 5.2
alcohol abuse 5.2
Abuse 5.2
TBS 5.1
cocaine addiction 5.1
compulsion 5.0
Habituation 5.0
drunk 4.9
petit mal 4.9
PCP 4.9
DBA 4.8
clinical depression 4.8
anguish 4.8
cocaine abuse 4.7
hypomania 4.6
tic 4.6
DWI 4.6
siderosis 4.6
GAD 4.5
substance abuse 4.5
heavy drinking 4.5
narcolepsy 4.5
RGS 4.4
trichotillomania 4.3
behavior disorder 4.3
anxiety disorders 4.3
PTP 4.3
hypochondriasis 4.3
Ludwig 4.3
pyuria 4.2
hepatorenal syndrome 4.2
galactorrhea 4.2
cataplexy 4.2
sexual dysfunction 4.2
alcohol use disorder 4.2
hallucinations 4.2
HOS 4.1
fear and anxiety 4.1
akinesia 4.1
bruxism 4.1
stereotypies 4.1
delirium 4.0
galactorrhea 3.9
priapism 3.8
amnesia 3.8
xerostomia 3.8
depression 3.7
tetraplegia 3.7
HSS 3.7
Leigh syndrome 3.7
sympathomimetic 3.7
MICA 3.7
lysosomal storage disease 3.7
agoraphobia 3.7
senile dementia 3.6
binge eating 3.6
Dementia with Lewy bodies 3.5
SCH 3.5
panic disorder 3.5
PAM 3.4
ICD 3.4
CAM 3.4
antisocial behavior 3.3
RSV infection 3.2
proptosis 3.2
substance use disorders 3.2
borderline personality disorder 3.1
confusion 3.1
hepatic encephalopathy 3.1
NAME 3.1
respiratory disease 3.1
Neuroblastoma 3.1
Neuroblastoma 3.1
fecal incontinence 3.1
coma 3.1
disinhibition 3.0
social phobia 3.0
panic attacks 3.0
substance use 3.0
social stress 2.9
CNS diseases 2.9
Frey 2.9
anhedonia 2.9
affective disorder 2.8
rheumatism 2.8
psychosis 2.7
gastroesophageal reflux disease 2.7
sinusitis 2.7
Gaucher disease 2.7
Tourette syndrome 2.6
phenylketonuria 2.6
sexual assault 2.5
sleep disorders 2.5
diabetic neuropathy 2.4
cognitive impairment 2.4
chronic disease 2.4
posttraumatic stress disorder 2.4
nystagmus 2.4
SAR 2.4
Dissociation 2.3
stress incontinence 2.3
obsessive-compulsive disorder 2.3
psychopathy 2.3
FAS 2.2
erythroleukemia 2.2
Evans 2.2
more...
Symptom
tonic seizure 8.1
physical symptom 7.3
cancer pain 6.9
muscle rigidity 6.7
retching 6.7
analgesia 6.7
impaired motor coordination 6.6
generalized pain 6.6
polydipsia 6.6
persistent cough 6.6
acute low back pain 6.1
acute pain 6.1
lassitude 6.1
incoordination 6.0
thirsty 5.9
constipation 5.8
intention tremor 5.8
Neuropathic pain 5.8
hyperacusis 5.7
hangover 5.7
tachypnea 5.7
prostration 5.7
tremor 5.6
breakthrough pain 5.5
loss of balance 5.4
blackout 5.4
hyperesthesia 5.2
insomnia 5.0
hypertonia 4.9
tonic-clonic seizure 4.9
Sedation 4.8
hypothermia 4.8
clonus 4.7
sleepiness 4.7
chronic back pain 4.7
dizziness 4.6
renal colic 4.6
ataxia 4.4
dysesthesia 4.3
agitation 4.3
twitching 4.2
seizures 4.2
catatonia 4.1
nausea 4.1
nasal congestion 4.1
diarrhea 4.1
decreased appetite 4.0
dental pain 4.0
asthenia 3.9
bitter taste 3.8
pain 3.7
vomiting 3.7
photophobia 3.6
nausea and vomiting 3.6
abdominal discomfort 3.5
hunger 3.3
sneezing 3.3
cough 3.1
anorexia 3.1
hopelessness 3.0
facial pain 3.0
dysuria 3.0
shortness of breath 2.9
sore throat 2.8
lethargy 2.8
bone pain 2.6
myalgia 2.5
dysarthria 2.3
apathy 2.2
myoclonus 2.2
paresthesia 2.0
low back pain 1.9
numbness 1.9
anesthesia 1.9
ENT 1.9
weakness 1.8
headache 1.8
cachexia 1.8
hypotonia 1.7
back pain 1.7
spasticity 1.6
functional recovery 1.5
vertigo 1.4
spasm 1.4
discomfort 1.4
discomfort 1.2
dystonia 1.2
respiratory distress 1.0
fatigue 0.9
erythema 0.5
overweight 0.5
stigma 0.5
acidity 0.3
chest pain 0.2
starvation -0.4
dyspnea -0.5
abdominal pain -0.7
Drug
Halazepam 12.6
Flupirtine maleate 11.9
Zomepirac sodium 11.2
Hydrocodone bitartrate 11.2
Buspar 11.1
Bretazenil 10.7
Buspar 10.5
Uncaria hook 10.4
Butorphanol 10.2
Magnolia bark 9.7
Tuareg 9.6
Xyrem 9.3
Brotizolam 9.2
Abecarnil 9.1
Alpidem 8.9
Subutex 8.9
LAAM 8.6
Tianeptine 8.5
Tapentadol 8.4
Narcan 8.0
Ramelteon 7.9
7-Nitroindazole 7.8
Ketorolac tromethamine 7.4
Compound 18 7.4
Morphine sulfate 7.4
Proglumide 7.3
Aprepitant 7.0
CET 6.9
GVG 6.9
Ritanserin 6.7
Tween 40 6.6
Phosphoramidon 6.5
Fentanyl 6.2
Triazolam 6.2
Pitressin 6.2
Ethanol 6.1
Ketorolac 6.0
Rimonabant 5.9
PCP 5.8
Codeine 5.8
9-THC 5.8
Flunitrazepam 5.7
Codeine 5.7
Zonisamide 5.7
Papaverine 5.4
Clonidine 5.3
CDP 4.6
Gabapentin 4.4
Adenosine triphosphate 4.4
Photofrin 4.4
DFP 4.4
Diphenhydramine 4.2
ICI 4.2
Phentolamine 4.0
DPA 3.9
Phenytoin 3.8
Glycyrrhiza 3.8
caffeine 3.7
Diurnal 3.5
Theophylline 3.2
Propofol 3.2
Dakar 3.2
DHT 3.1
DHT 3.1
Ouabain 2.9
CTX 2.9
ETS 2.9
Ringer's solution 2.8
CAM 2.7
ADM 2.6
HCH 2.5
p75 2.3
Glutathione 1.8
CTX 1.8
CTX 1.7
ascorbate 1.3
ROC 1.3
Spectrum 1.3
lactose 1.2
Biopolymers 1.2
ENT 1.2
nitroglycerin 1.1
Nephron 1.1
citric acid 1.0
CSF 0.9
NADH 0.8
Leaf -0.2
IL-2 -0.6
Enzyme
DIPP 9.8
PCP 5.8
asparaginase 5.4
glutaminase 4.9
CaMKII 4.8
monoacylglycerol lipase 4.8
carboxypeptidase A 4.3
GRK5 4.1
monoamine oxidase 3.8
demethylase 3.8
dopamine beta-hydroxylase 3.8
histidine decarboxylase 3.7
Alternating 3.6
aryl hydrocarbon hydroxylase 3.6
succinic dehydrogenase 3.5
tryptophan hydroxylase 3.4
prostaglandin synthetase 3.4
PAM 3.4
adenylate cyclase 3.3
glutamate decarboxylase 3.1
alcohol dehydrogenase 3.0
tyrosine hydroxylase 3.0
AMPK 3.0
PKG 2.9
CPR 2.9
MDP 2.8
5'-nucleotidase 2.6
protein kinase C 2.5
nitrate reductase 2.4
nitrate reductase 2.4
nitrate reductase 2.4
nitrate reductase 2.4
nitrate reductase 2.4
nitrate reductase 2.3
NADPH-diaphorase 2.3
MMP 2.2
lipoxygenase 2.1
acetylcholinesterase 2.0
phospholipase A2 2.0
protein kinase 1.9
NADPH oxidase 1.9
NO synthase 1.9
NQO1 1.6
succinate dehydrogenase 1.2
RNase 1.2
cdc2 1.2
calcineurin 1.2
RNase 1.1
MEK 1.1
CD10 1.0
mitogen-activated protein kinase 0.9
NADPH oxidase 0.8
cholinesterase 0.6
P-glycoprotein 0.5
ATPase 0.2
ACE 0.1
phosphodiesterase 0.0
creatine kinase 0.0
ERK 0.0
glutathione peroxidase -0.2
ACS -0.4
alanine aminotransferase -0.5
lactate dehydrogenase -0.6
reverse transcriptase -0.7
alkaline phosphatase -1.3
catalase -1.5
peroxidase -1.8
Compound
1-methyl-4-piperidinol 12.6
Levallorphan 11.6
DuP 697 10.6
D-Histidine 10.3
Gelsemine 10.2
Butorphanol 10.2
Thebaine 9.7
D-Phenylalanine 9.5
Nalorphine 9.3
Mequitazine 9.0
Mequitazine 9.0
Mequitazine 9.0
Mequitazine 9.0
4-piperidinol 8.9
Hydromorphone 8.8
SR 141716 8.8
C6H8O4 8.7
delta8-THC 8.7
Ethylketocyclazocine 8.6
Veronal 8.6
Buprenorphine 8.6
Cyclazocine 8.6
Hydrocodone 8.6
decahydroisoquinoline 8.5
Morphine 8.5
Levorphanol 8.5
Propoxyphene 8.4
Naloxone 8.4
Bergenin 8.3
Buspirone 8.3
Benzoylecgonine 8.1
A101 8.1
X 13 8.0
Zolpidem 8.0
Aniracetam 8.0
Hexobarbital 7.9
Nalbuphine 7.9
4-phenylpiperidine 7.9
Flumazenil 7.9
Tizanidine 7.7
Barbiturate 7.7
Oleamide 7.7
Prone 7.6
Pargyline 7.6
Morphine sulfate 7.6
202-791 7.5
Doxepin 7.5
Cytisine 7.5
BDH 7.5
Alprazolam 7.5
Heroin 7.5
DHM 7.4
Endomorphin-1 7.4
Naltrexone 7.4
EEDQ 7.4
Guanabenz 7.3
Temazepam 7.3
Oxycodone 7.2
Agmatine 7.2
Risperidone 7.1
Tramadol 7.1
Metiamide 7.1
Tranylcypromine 7.1
Hexobarbital 7.0
Sinomenine 7.0
Caryophyllene 7.0
2,4-dichlorophenyl 7.0
2,4-dichlorophenyl 7.0
Methadone 6.9
Oxazepam 6.8
Sufentanil 6.8
NOP 6.6
Nitrazepam 6.5
Sibutramine 6.5
Pentazocine 6.5
Phosphoramidon 6.5
Nitrendipine 6.4
TIF 6.4
Alfentanil 6.4
DAMGO 6.4
1,1,2-trichloroethane 6.4
Midazolam 6.3
cyclohexanecarboxamide 6.3
Pentazocine 6.3
1H-pyrazole 6.2
Paroxetine 6.2
Saccharin 6.2
Ketorolac 6.2
Allopregnanolone 6.2
2-methylpiperazine 6.2
ecgonine methyl ester 6.2
Ephedrine 6.2
Chloral hydrate 6.1
DLG 6.1
Pentobarbital 6.1
2-pyrrolidinone 6.1
GYKI 52466 6.1
Allopregnanolone 6.0
Glycine, 6.0
1H-pyrazole 6.0
Mecamylamine 6.0
Loperamide 6.0
Spiperone 6.0
Honokiol 5.9
2-butenyl 5.9
Mepyramine 5.9
D-Ala 5.9
Chlordiazepoxide 5.9
2-butenyl 5.8
gamma-hydroxybutyric acid 5.8
6-Hydroxydopamine 5.8
Pimozide 5.8
Codeine 5.8
PNU 5.8
Remifentanil 5.8
1,1,1-trichloroethane 5.7
R 2 5.7
Glycine, 5.6
Pindolol 5.6
EAA 5.6
CNA 5.6
Sumatriptan 5.6
THIP 5.6
PCP 5.6
Baclofen 5.6
AEA 5.5
MK801 5.5
pyridazine 5.5
pyridazine 5.5
Lorazepam 5.5
Corticotropin 5.5
ethanol 5.5
d-Amphetamine 5.5
AEA 5.5
2-pyrrolidinone 5.4
Venlafaxine 5.4
Ceftriaxone 5.4
Papaverine 5.4
TBS 5.3
Pentobarbital 5.3
MOP 5.3
VMA 5.2
Dynorphin 5.2
4-chlorophenyl 5.1
4-chlorophenyl 5.1
Bupropion 5.1
Nicotine 5.1
Diazepam 5.0
ECS 5.0
1,2,3,4-tetrahydroisoquinoline 5.0
DBA 5.0
cyclopentyl 5.0
DBA 5.0
dipropyl 5.0
MHPG 4.9
Nordihydroguaiaretic acid 4.9
CPA 4.8
cinnamyl 4.8
GABA 4.8
GABA 4.8
more...