Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278080 (physical dependence)
 1,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
opioid receptor 135
Sep 108
GABA 50
Mol 32
NMDA receptor 31
mu opioid receptor 25
beta-endorphin 21
DBA 15
Gen 15
nitric oxide synthase 13
5-hydroxytryptamine 12
delta opioid receptor 12
calcium channel 11
CB1 11
PCP 11
adenylate cyclase 10
dynorphin 10
NR2B 10
WIN 9
adenylyl cyclase 9
CA1 9
GABA(A) receptor 9
substance P 9
calcitonin 8
tap 8
glutamate receptor 7
THC 7
orexin 7
L-type calcium channel 7
nicotinic acetylcholine receptor 7
membrane-bound 7
tyrosine hydroxylase 7
CA3 6
cholecystokinin 6
Leu5 6
Met-enkephalin 6
interferon 6
neuronal nitric oxide synthase 6
L-asparaginase 6
cannabinoid receptor 6
CAS 6
calmodulin 6
cage 6
microsomal 6
vasopressin 6
kappa opioid receptor 5
rat) 5
OFQ 5
CaMKII 5
polypeptide 5
Met 5
5-HT1A 5
ICD 5
mouse) 5
NR1 5
cAMP-dependent protein kinase 5
AMP 5
acetylcholinesterase 5
glutamate transporter 4
DAF 4
Tic 4
PKC 4
bradykinin B2 receptor 4
ATPase 4
NR2A 4
endoplasmic reticulum 4
neutral endopeptidase 4
ERK1 4
HT3 4
prodynorphin 4
MOR-1 4
albumin 4
brain-derived neurotrophic factor 4
alcohol dehydrogenase 4
ASP 3
DIPP 3
GSH 3
TRH 3
thymus 3
MAPK 3
reserved 3
c-fos 3
cAMP response element binding protein 3
MIF 3
JAMA 3
cAMP response element-binding protein 3
Neuropeptide FF 3
APA 3
peptidase 3
SCH 3
KOR 3
ACS 3
ANA 3
ionotropic 3
Orexin 3
GluR5 3
CSF 3
beta 1 3
muscarinic receptor 3
Pol 3
G protein-coupled receptor 3
brain protein 3
Leu-enkephalin 3
CCK 3
GTP 3
olfactory 3
ATP 3
chloride channel 3
Cad 3
Mu opioid receptor 3
corticotropin-releasing factor 3
REM 3
arrestin 3
OPRM1 3
ERK 3
arginine vasopressin 2
JNK 2
GTPase 2
castor 2
galanin 2
reductase 2
neurotensin 2
interleukin-6 2
Cav1.3 2
interleukin-4 2
dimeric 2
PLA 2
extracellular signal-regulated kinase 2
arrestin 2 2
antioxidant enzyme 2
SAR 2
dopamine D2 receptor 2
ARC 2
cytochrome b5 2
gut 2
OXR1 2
mu2 2
PSD-95 2
CDP 2
phospholipase A2 2
cytochrome P-450 2
sigma receptor 2
CAM 2
NMDA receptor subunit 2
EphB1 2
prolactin 2
MEK 2
GLT-1 2
guanine nucleotide-binding regulatory protein 2
NMR 2
CO2 2
dopamine D1 receptor 2
Iba1 2
interleukin-2 2
AC8 2
lipoxygenase 2
dopamine D3 receptor 2
COX-2 2
glutaminase 2
cytokine 2
more...
Disease
physical dependence 1658
addiction 193
depression 120
alcoholism 78
fits 68
chronic pain 53
drug addiction 45
drug abuse 29
prolapse 23
alcohol abuse 22
cancer 20
drug withdrawal 18
Dependence 18
anxiety disorders 16
substance abuse 16
Abuse 16
DBA 15
nicotine addiction 14
Opiates 12
PCP 11
confusion 10
psychosis 10
cognitive impairment 10
alcohol withdrawal syndrome 10
cold 9
tobacco dependence 9
dysphoria 8
schizophrenia 8
coma 7
THC 7
stroke 7
dementia 7
hallucinations 7
HIV 6
cirrhosis 6
substance use 6
NAME 6
Cannabis 6
catalepsy 6
aggression 5
tranquilizers 5
respiratory disease 5
herpes simplex 5
diabetes 5
epilepsy 5
virus infection 5
delirium 5
violence 5
ICD 5
posttraumatic stress disorder 5
chronic disease 5
delirium tremens 5
drunk 5
neuroblastoma 5
mental illness 4
tic 4
asthma 4
cross-dependence 4
gastroesophageal reflux disease 4
amnesia 4
AIDS 4
Tic 4
sexual dysfunction 4
migraine 4
pertussis 4
Morphine dependence 4
CAM 3
West 3
fatty liver 3
clinical depression 3
heroin addiction 3
heavy drinking 3
neuropathy 3
heroin abuse 3
narcotic dependence 3
tumor 3
malnutrition 3
panic disorder 3
obesity 3
narcolepsy 3
hyperlipidemia 3
immunodeficiency 3
chronic obstructive pulmonary disease 3
Evans 3
SCH 3
xerostomia 3
pruritus 3
GAD 3
lung cancer 3
suicide 3
GSH 3
Alzheimer's disease 2
liver fibrosis 2
vascular disease 2
proptosis 2
binge eating 2
morning drinking 2
SAR 2
liver disease 2
excessive drinking 2
encephalopathy 2
compulsion 2
akinesia 2
nystagmus 2
Best 2
tetraplegia 2
sleep disorders 2
obsessive-compulsive disorder 2
neonatal abstinence syndrome 2
cocaine abuse 2
psychomotor impairment 2
suicidal ideas 2
osteoporosis 2
anxiety neurosis 2
Opioid dependence 2
emphysema 2
borderline personality disorder 2
disinhibition 2
substance use disorders 2
polydrug abuse 2
dehydration 2
hepatic encephalopathy 2
tuberculosis 2
alcohol use disorder 2
sympathomimetic 2
cholera 2
bone cancer 2
sinusitis 2
cocaine addiction 2
peripheral neuropathy 2
affective disorder 2
cholestasis 2
hypertension 2
glioma 2
cataplexy 1
Nicotine withdrawal 1
Poland 1
rheumatism 1
parkinsonism 1
sleep disturbances 1
anguish 1
DWI 1
Habituation 1
Dementia with Lewy bodies 1
celiac disease 1
bruxism 1
vasculitis 1
Duchenne muscular dystrophy 1
CNS diseases 1
Edwards 1
duodenal ulcer 1
ischemia 1
MICA 1
hypochondriasis 1
metabolic disorder 1
hypoglycemia 1
fecal incontinence 1
Dissociation 1
audiogenic seizure 1
phenylketonuria 1
more...
Symptom
pain 178
analgesia 152
seizures 78
diarrhea 50
tremor 47
constipation 30
hypothermia 25
vomiting 21
anesthesia 21
nausea 21
cancer pain 19
insomnia 18
ataxia 18
sleepiness 17
acute pain 14
agitation 12
dizziness 12
polydipsia 11
cough 11
headache 10
tachypnea 7
weakness 7
anorexia 6
nausea and vomiting 6
muscle rigidity 6
incoordination 6
fatigue 5
Neuropathic pain 4
retching 3
hunger 3
persistent cough 3
tonic seizure 3
discomfort 3
discomfort 3
myalgia 2
physical symptom 2
shortness of breath 2
overweight 2
functional recovery 2
asthenia 2
hypertonia 2
twitching 2
back pain 2
tonic-clonic seizure 2
respiratory distress 2
Sedation 2
lethargy 2
low back pain 2
apathy 1
cachexia 1
numbness 1
hyperesthesia 1
loss of balance 1
photophobia 1
lassitude 1
blackout 1
stigma 1
decreased appetite 1
chronic back pain 1
vertigo 1
impaired motor coordination 1
acute low back pain 1
ENT 1
dyspnea 1
dystonia 1
sore throat 1
catatonia 1
hypotonia 1
dysuria 1
breakthrough pain 1
paresthesia 1
abdominal pain 1
sneezing 1
hopelessness 1
facial pain 1
hyperacusis 1
dysarthria 1
acidity 1
prostration 1
renal colic 1
starvation 1
dental pain 1
spasticity 1
intention tremor 1
thirsty 1
chest pain 1
myoclonus 1
abdominal discomfort 1
hangover 1
bone pain 1
nasal congestion 1
erythema 1
generalized pain 1
bitter taste 1
spasm 1
dysesthesia 1
clonus 1
Drug
Ethanol 36
caffeine 15
PCP 11
Butorphanol 11
Fentanyl 5
ICI 5
9-THC 5
Clonidine 5
CTX 4
CSF 3
ascorbate 3
Tianeptine 3
CDP 3
Zomepirac sodium 2
Subutex 2
CAM 2
Buspar 2
Brotizolam 2
Bretazenil 2
Nephron 2
NADH 2
Buspar 2
Tapentadol 2
Halazepam 2
lactose 2
LAAM 2
Rimonabant 1
Abecarnil 1
Magnolia bark 1
Zonisamide 1
Phenytoin 1
Flupirtine maleate 1
Theophylline 1
Triazolam 1
CTX 1
Ramelteon 1
Diphenhydramine 1
DPA 1
ROC 1
Tween 40 1
nitroglycerin 1
Morphine sulfate 1
Codeine 1
Narcan 1
Flunitrazepam 1
Leaf 1
Compound 18 1
Hydrocodone bitartrate 1
p75 1
Biopolymers 1
Spectrum 1
HCH 1
Codeine 1
Dakar 1
7-Nitroindazole 1
DHT 1
Ringer's solution 1
ENT 1
Aprepitant 1
Diurnal 1
Proglumide 1
Pitressin 1
Papaverine 1
Glutathione 1
DHT 1
GVG 1
CTX 1
Gabapentin 1
IL-2 1
Ketorolac tromethamine 1
Alpidem 1
citric acid 1
Adenosine triphosphate 1
Xyrem 1
Ritanserin 1
Uncaria hook 1
Photofrin 1
CET 1
Ouabain 1
Tuareg 1
Ketorolac 1
ETS 1
DFP 1
Phosphoramidon 1
Phentolamine 1
ADM 1
Propofol 1
Glycyrrhiza 1
Enzyme
protein kinase 16
protein kinase C 15
PCP 11
adenylate cyclase 10
mitogen-activated protein kinase 9
monoamine oxidase 8
tyrosine hydroxylase 6
CaMKII 6
acetylcholinesterase 6
asparaginase 6
AMPK 5
ERK 5
ATPase 4
demethylase 4
alcohol dehydrogenase 4
ACS 3
phospholipase A2 3
glutaminase 3
DIPP 3
NO synthase 3
NADPH oxidase 2
calcineurin 2
lipoxygenase 2
RNase 2
RNase 2
MEK 2
CPR 2
NQO1 1
5'-nucleotidase 1
NADPH-diaphorase 1
monoacylglycerol lipase 1
nitrate reductase 1
succinate dehydrogenase 1
creatine kinase 1
P-glycoprotein 1
PKG 1
phosphodiesterase 1
succinic dehydrogenase 1
catalase 1
MMP 1
tryptophan hydroxylase 1
GRK5 1
MDP 1
nitrate reductase 1
peroxidase 1
carboxypeptidase A 1
dopamine beta-hydroxylase 1
PAM 1
cdc2 1
nitrate reductase 1
glutathione peroxidase 1
glutamate decarboxylase 1
nitrate reductase 1
alanine aminotransferase 1
cholinesterase 1
lactate dehydrogenase 1
aryl hydrocarbon hydroxylase 1
histidine decarboxylase 1
NADPH oxidase 1
nitrate reductase 1
prostaglandin synthetase 1
CD10 1
reverse transcriptase 1
nitrate reductase 1
Alternating 1
ACE 1
alkaline phosphatase 1
Compound
ethanol 327
Dec 119
Morphine 98
water 83
Clin 75
Naloxone 65
GABA 50
GABA 50
calcium 36
glutamate 31
cAMP 30
sulfate 30
tyrosine 27
Phe 23
sodium 22
Gly 21
gamma-aminobutyric acid 20
noradrenaline 19
NMDA 18
Buprenorphine 17
arginine 17
Nicotine 16
caffeine 16
leucine 16
DBA 15
DBA 15
DBA 15
methionine 12
5-HT 11
DNA 11
glucose 11
PCP 11
Diazepam 11
DSM 10
acetic acid 10
Butorphanol 10
NIDA 9
Risperidone 9
Naltrexone 9
NH2 9
aspartic acid 9
HCl 9
nitric oxide 9
Methadone 8
Buspirone 8
aldehyde 8
galactose 6
D-Ala 6
AMP 6
Zolpidem 6
piperazine 6
DAMGO 6
Cocaine 6
threonine 6
Flumazenil 6
Heroin 6
acetaldehyde 6
oxygen 5
Midazolam 5
Asp 5
AMPA 5
ICI 5
Tramadol 5
phosphate 5
4-chlorophenyl 5
4-chlorophenyl 5
aldehyde 4
aspartic acid 4
GSH 4
nitrogen 4
CTX 4
aspartic acid 4
aspartic acid 4
GSH 4
Prone 4
1H-pyrazole 4
zinc 4
2,4-dichlorophenyl 4
Salt 4
hydroxyindoleacetic acid 4
His 4
alcohol dehydrogenase 4
TRH 4
2,4-dichlorophenyl 4
1H-pyrazole 4
Pentobarbital 3
Agmatine 3
ANA 3
ACS 3
propionic acid 3
potassium 3
GM1 3
Veronal 3
tryptophan 3
AEA 3
urea 3
Glutamate 3
cyclopentyl 3
MK801 3
Pentobarbital 3
alanine 3
GTP 3
1-methyl-4-piperidinol 3
2-methylpiperazine 3
ACS 3
tryptophan 3
Baclofen 3
tryptophan 3
iron 3
tryptophan 3
Alprazolam 3
propionic acid 3
ANA 3
ATP 3
CPA 3
acetamide 2
gamma-hydroxybutyric acid 2
Ketamine 2
Sodium 2
TSH 2
pyridazine 2
CAM 2
Nitrendipine 2
salt 2
R 2 2
ACTH 2
A101 2
CPA 2
SR 141716 2
piperidine 2
CDP 2
pyridazine 2
Oxycodone 2
Hydromorphone 2
Barbiturate 2
Propranolol 2
MOP 2
Dopamine 2
Propranolol 2
acetamide 2
glutamine 2
acetate 2
propylene glycol 2
lysine 2
Ceftriaxone 2
hydrogen 2
CPA 2
vinyl 2
cyanide 2
toluene 2
PGE2 2
dipropyl 2
CPA 2
Nalbuphine 2
serine 2
Methamphetamine 2
prostaglandin E1 2
APAP 2
CO2 2
Pargyline 2
more...