Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0278080 (
physical dependence
)
1,658
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Male Swiss mice, when exposed to increasing concentrations of ethanol vapor for a period of 9 days, developed tolerance to as well as
physical dependence
on ethanol.
Desferrioxamine
, an iron-chelator and a lipid peroxidation inhibitor, administered to individual mice at a daily dose of 350 mg/kg body weight, caused a reduction in the degree of dependence but not of tolerance. Also, desferrioxamine protected the mice against the reduction in body weight increment observed over the inhalation period. It is suggested that desferrioxamine acts either via inhibiting the ethanol-induced lipid peroxidation, suspected to be involved in dependence, or via a different iron-sensitive mechanism.
...
PMID:Reduction in severity of physical dependence on ethanol in mice caused by desferrioxamine administration. 668 7
