Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0278080 (physical dependence)
 1,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of ethanol dependence and withdrawal on pituitary hormone content and corticosterone release were investigated in AKR/J male mice in a vapor chamber. Both chronic ethanol inhalation and ethanol withdrawal were associated with increased adenohypophyseal-adrenocortical activity. Operationally, ethanol exposure was a stressor. Both physical dependence and withdrawal led to increased secretion/synthesis ratios of peptide hormones. The temporal pattern of pituitary ACTH-IR content changes was different from that of beta-endorphin-IR and alpha-MSH-IR. Differences in the pattern of ACTH-IR and alpha-MSH-IR most probably represent lobe-specific differences in the response to chronic ethanol exposure and withdrawal.
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PMID:Ethanol dependence and the pituitary adrenal axis in mice. II. Temporal analysis of dependence and withdrawal. 631 51