Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0278080 (
physical dependence
)
1,658
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
D-Histidine
, administered in the 'wthdrawal' phase of morphine addiction, failed to modify the expression of tolerance and
physical dependence
in mice. L-Histidine, on the contrary, can enhance tolerance and inhibit
physical dependence
. Whole brain histamine is markedly increased by L-histidine administration, but only minimally by D-histidine. This confirms that the actions of L-histidine on morphine addiction are stereospecific, and so can be more confidently correlated with the increase in brain histamine levels produced by the natural amino acid precursor.
...
PMID:The effects of D-histiding on the expression of morphine tolerance and physical dependence in mice. 56 20
