Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0278080 (
physical dependence
)
1,658
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The activities of the brain L-asparaginase and
angiotensin converting enzyme
(
ACE
), and the plasma cortisol level were found to be decreased in the rats implanted with morphine (M) containing pellets. Even though 10 mg/kg of naloxone (N) itself showed an inhibitory effect on
ACE
it abolished the inhibitions seen in the M dependent rats five min following subcutaneous injection. The chronic administration of L-aspartic acid (ASP) during the development of
physical dependence
or just before the N injection prevented the increase of the plasma cortisol caused by N. It is concluded that in addition to the inhibition of the brain L-asparaginase activity which was previously hypothesized to be the main reason of the development of
physical dependence
on opiates as a result of the related experimental and clinical data, the inhibition by M of the brain
ACE
activity may take part in the development of
physical dependence
. With regard to the plasma cortisol level, the concomitant administration of ASP with M blocks, to a great extent, the development of
physical dependence
on opiate. The single dose of ASP administration before N injection prevents the effect of N, the manifestation of abstinence syndrome.
...
PMID:Brain asparaginase, ACE activity and plasma cortisol level in morphine dependent rats: effect of aspartic acid and naloxone. 302 85
