Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0278080 (
physical dependence
)
1,658
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Opiates, long considered the prototypical addictive drug, cause the phenomenon of tolerance and
physical dependence
following chronic administration. Although many factors promote the addictive state, our studies have focused on the role of endogenous morphine in modifying
physical dependence
. Mammalian tissues contain morphine and codeine and have the capacity to synthesize these alkaloids. The present report shows that N-acetylmuramyl-L-alanine-D-isoglutamine (
MDP
), which elevates the endogenous opiate alkaloids in various brain regions and peripheral tissues, can attenuate the withdrawal syndrome of morphine-addicted rats.
...
PMID:Role of endogenous morphine in the attenuation of opiate withdrawal syndrome by N-acetylmuramyl-L-alanine-D-isoglutamine (MDP). 879 96
