Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0278080 (physical dependence)
 1,658 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The great increase in the number of patients with chronic kidney disease (CKD) can be explained by a number of reasons. Elderly patients present typical and peculiar clinical features, and nephrologists have to consider the frequent clinical complications related to old age, such as malnutrition and cachexia, cognitive impairment and physical dependence with walking disability and depression. All of these factors have led to the birth of geriatric nephrology. Geriatric nephrology needs to take into account the high prevalence of diabetes and vascular disease in the elderly, which is related to a poor prognosis, mainly related to cerebrocardiovascular mortality. Best everyday clinical practice should include an accurate evaluation of patients, including quality of life, to select the best therapeutic approach for each individual case. A careful and reasonable use of drugs in the elderly is also of importance.
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PMID:Geriatric nephrology. 2087 65

There is an ever-increasing number of opioid users among chronic pain patients and safely managing them can be challenging for surgeons, anesthesiologists, pain experts, and addiction specialists. Healthcare providers must be familiar with phenomena typical of opioid users and abusers, including tolerance, physical dependence, hyperalgesia, and addiction. Insufficient pain management is very common in these patients. Patient-centered preoperative communication is integral to setting realistic expectations for postoperative pain, developing successful nonopioid analgesic regimens, minimizing opioid consumption during the postoperative period, and decreasing the number of opioid pills at the risk of diversion. Preoperative evaluation should identify comorbidities and identify risk factors for substance abuse and withdrawal. Intraoperative and postoperative strategies can ensure safe and effective pain management and minimize the potential for morbidity and mortality in this high-risk patient population.
Best Pract Res Clin Anaesthesiol 2020 Jun
PMID:Chronic pain and substance abuse disorders: Preoperative assessment and optimization strategies. 3271 32