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Query: UMLS:C0277787 (stigma)
 13,352 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The data presented suggest that general practitioners would be likely to refer a large number of patients with diverse problems to clinical psychologists working in health centres. Compared with a centrally organized clinical psychology service, the work of the primary care psychologist is likely to offer the following advantages:1. Access to psychological help for patients with a need for such help, but who could not attend a central clinic owing to problems associated with travel, work, physical disability, or even a presenting problem such as agoraphobia.2. Greater continuity of care of patients.3. Increased communication between the psychologist and members of the primary care teams.4. Possibility of the psychologist seeing the patient earlier, before the problems have become entrenched.5. Less need for referral to other agencies.6. Reduced stigma for the patient.7. Development of new therapeutic approaches relevant to problems presenting in primary care.8. More flexible and more relevant therapy due to seeing the patients in their home setting.9. Greater therapeutic involvement of the patient's family.10. Reduced costs and inconvenience for the patient's family.11. Reduced administrative and ambulance service costs.While these points do not overcome the need for a formal evaluation of the work of psychologists in primary care, they do suggest that there are advantages in this type of service over the services which are currently available and that a full evaluation would be worth undertaking.
J R Coll Gen Pract 1978 Nov
PMID:The work of a clinical psychologist in primary care. 73 67

Genetic and molecular analysis of the self-incompatibility locus (S-locus) of the crucifer Brassica has led to the characterization of a multigene family involved in pollen-stigma interactions. While the crucifer Arabidopsis thaliana does not have a self-incompatibility system, S-related sequence were detected in this species by cross-hybridization with Brassica DNA probes. In this paper, we show that an A. thaliana S-related sequence, designated AtS1, is expressed specifically in flower buds. Sequence analysis suggests that AtS1 encodes a secreted glycoprotein that is most similar to the Brassica S-locus related protein SLR1. As has been proposed for SLR1, this gene may be involved in determining some fundamental aspect of pollen-stigma interactions during pollination. The molecular and genetic advantages of the Arabidopsis system will provide many avenues for testing this hypothesis.
Mol Gen Genet 1992 Feb
PMID:Structure and expression of AtS1, an Arabidopsis thaliana gene homologous to the S-locus related genes of Brassica. 137 78

A self-incompatible canola-quality Brassica napus ssp. oleifera line (W1) was generated by introgressing the S-locus from a self-incompatible B. campestris plant into the Westar cultivar. Using the polymerase chain reaction (PCR) with primers derived from conserved regions in S-locus glycoprotein (SLG) alleles, the central region of the active SLG gene (910) was obtained. The remaining portions of the cDNA for this 910 gene were subsequently cloned using the PCR-rapid amplification of cDNA ends (RACE) procedure. Sequence analysis revealed that the 910 cDNA show a high degree of sequence similarity to SLG alleles associated with Class I self-incompatible lines. The 910 gene was found to be absent in the original self-compatible cv. Westar (B. napus) and segregated with self-incompatibility in a mixed population generated from a cross between self-incompatible W1 and self-compatible Westar. RNA blot analysis indicated that high levels of 910 mRNAs were present in the stigma as buds approached anthesis. Thus, the SLG allele of W1 transferred from B. campestris via backcrosses to a line of cv. Westar has been identified.
Mol Gen Genet 1992 Aug
PMID:Use of the polymerase chain reaction to isolate an S-locus glycoprotein cDNA introgressed from Brassica campestris into B. napus ssp. oleifera. 150 46

The sequence is reported of a cDNA molecule homologous to an mRNA from stigma tissue of Brassica oleracea plants homozygous for the S5 self-incompatibility allele. This cDNA is closely related to a previously published sequence designated SLR2, which was obtained from the same stigma cDNA library and is also related to the SLR1 gene, a cDNA for which has also been obtained from this library. Various B. oleracea lines differing in S alleles and of different varieties have been screened for the presence of particular S gene family sequences using a method involving hybridization of sequence-specific oligonucleotide probes to PCR products. The results indicate that a gene homologous to the sequence presented here is absent from a line lacking the S5 allele, though present in other lines containing the S5 allele, regardless of their genetic background. This finding suggests that the sequence represents a transcript of the SLG (S locus glycoprotein) gene. A similar approach has confirmed that a cDNA derived from a Brassica line containing the S29 allele is also S allele-specific. The predicted amino acid sequences derived from a number of S gene family sequences are compared using numerical methods and possible evolutionary relationships between them are discussed.
Mol Gen Genet 1992 Mar
PMID:An S5 self-incompatibility allele-specific cDNA sequence from Brassica oleracea shows high homology to the SLR2 gene. 155 30

Encopresis afflicts one in 100 children causing considerable stigma and parental concern. General practitioners are in a position to help in most cases but are often deterred by the psychoanalytical theories which have been developed to explain this problem. It is currently accepted that children with encopresis tend to retain stools. This leads to constipation, overstretching of sphincters and resultant faecal soiling. Physical and psychological perpetuating factors result in retention once again, thus completing a cycle of constipation and retention. Various precipitant and predisposing factors can maintain this cycle. Once physical causes have been excluded a simple behavioural approach can be adopted aimed at retraining the bowel. By using laxatives to prevent retention, gaining the child's confidence, cooperation and understanding and involving both the family and school, encopresis can be successfully managed in general practice.
Br J Gen Pract 1991 Dec
PMID:Encopresis in children: a cyclical model of constipation and faecal retention. 180 29

Self-incompatibility in Brassica oleracea is controlled by a single genetic locus (the S locus) with nearly 50 different alleles. In this paper, we report the characterization of the S2 allele, a pollen recessive self-incompatibility allele that exhibits weak DNA homology to the other previously sequenced S locus glycoprotein genes (SLG-6, -13, -14, -22 from alleles S6, S13, S14 and S22, respectively). Stigma cDNA clones with sequence homology to SLG-13 were isolated from two different S2 homozygous strains belonging to two different B. oleracea cultivars, var. alboglabra (Chinese kale) and var. italica (broccoli). The two S2 cDNA sequences are 90% homologous to each other, but only 70% homologous to SLG-13. Using the Chinese kale S2 genetic background, we demonstrate that the isolated alboglabra cDNA sequence is a transcript from a gene, designated SLG-2A that resides at the S locus, and propose that it is a putative determinant of S2 allelic specificity. Among the estimated 10-15 genomic copies of SLG-related genes detected in the S2 genome, we cloned and characterized the SLG-2A gene and another closely related and genetically linked gene copy, SLG-2B. A complete open reading frame that is 94% homologous to SLG-2A is located within SLG-2B. The existence of this intact duplicated S gene raises the possibility that SLG-2B may also be involved in the functioning of self-incompatibility in Brassica oleracea.
Mol Gen Genet 1990 Jul
PMID:A new class of S sequences defined by a pollen recessive self-incompatibility allele of Brassica oleracea. 198 Mar 34

As a result of long-term clinical research on former prisoners of the Nazi concentration camps, I analyzed the evolution of the clinical and psychopathological pattern of the KZ-syndrome. One can differentiate the following characteristic phases: psychosomatic inanition, latency of disease, personality and adaptation disturbances, a pseudo-neurotic and depressive phase, premature aging, and an organic phase. The stigma of KZ-syndrome is present in a second generation in different forms: personality disturbances, emotional and/or social immaturity, social disadaptation, higher frequency of neurotic states, divorce, alcoholism, and suicide. The camp stress has left in human nature traces so painful that they cannot disappear when the generation of former prisoners is gone.
Genet Soc Gen Psychol Monogr 1990 Feb
PMID:The evolution of mental disturbances in the concentration camp syndrome (KZ-syndrom). 218 95

During the years of 1981 and 1982, 89 former prisoners of the Auschwitz-Birkenau concentration camp responded to questionnaires on mussulmen-prisoners in the extreme phase of starvation disease. In this article, I describe the origin of the term "mussulman," mussulmens' somatic and mental state, their behavior and camp customs. Prisoners characterized as mussulmen remain between life and death, without expressing emotional reactions and defense mechanisms apart from a hypersensibility to food-related stimuli. A mussulman was a product of the camp factory of death. A deep somatic and emotional stigma remains in those who survived the mussulmen state.
Genet Soc Gen Psychol Monogr 1990 Feb
PMID:Between life and death: experiences of concentration camp mussulmen during the holocaust. 232 15

The sporophytic self-incompatibility system of Brassica species is controlled by a single locus, S. Recognition of self between pollen and stigma is probably mediated by S locus-specific glycoproteins (SLSGs). We describe the isolation, from an S29 homozygote of Brassica oleracea, of two different cDNA clones for transcripts which are equally abundant in stigmas competent for self-incompatibility and each of which is homologous to previously reported SLSG sequences. Extensive DNA sequence divergence between the two clones precludes their cross-hybridisation and each acts as a gene-specific probe. All S genotypes appear to have a single copy of each gene but there are significantly different levels of polymorphism associated with each. The clear structural homology between the two indicates a gene duplication involving the S locus and, perhaps, related to the evolution of self-incompatibility.
Mol Gen Genet 1989 Jul
PMID:A homozygous S genotype of Brassica oleracea expresses two S-like genes. 255 Jul 59

Although much is known about morphological changes in the apex of the mammalian ovarian follicle prior to its rupture (ovulation), information about this process in nonmammalian vertebrates is limited to only a few species. We describe here the histological changes in the stigma of the lizard (Anolis carolinensis) ovarian follicle preceding FSH-induced ovulation. Females with a large vitellogenic follicle received two injections, separated by 7 hr, of either porcine FSH (25 micrograms) or saline, and then were sampled at 6, 9, 12, 15, 18, and 24 hr after the first injection. Thus, all but the 6-hr group received two injections. By 12 hr, about half of the FSH-treated females had ovulated, and most had ovulated by 15 hr. In contrast, only 1 of 40 control females ovulated. Large unovulated follicles were fixed and bisected through the circular stigma; one hemisphere was embedded in paraffin and stained with Mallory's trichrome, and the other was embedded in plastic and stained with toluidine blue. FSH treatment produced marked histological changes in the stigma region, as well as alterations in nonstigmal areas of the follicle. The membrana granulosa of control follicles consisted of a single layer of squamous, darkly staining granulosa cells. After FSH treatment, nonstigmal granulosa cells separated slightly, and their nuclei became more clear and assumed an oval shape; in the stigma, these cells became widely separated, with round, light-staining nuclei containing one or two prominent nucleoli. The nonstigmal theca of FSH-treated follicles was similar to that of control follicles except that collagen fibers were more dissociated. In the stigma, collagen fibers were widely dissociated, and the theca swelled, presumably due to accumulation of extracellular fluid. Abundant fluid accumulated in the stigma, especially between the granulosa cells and their basement membrane and between the tunica albuginea and the theca externa. These changes in the lizard stigma are similar to those reported in mammals except that no marked inflammatory response occurs in the lizard stigma. We hypothesize that the Anolis follicle undergoes preovulatory luteinization, and that the stigma exhibits ischemic necrosis before rupture.
Gen Comp Endocrinol 1988 Nov
PMID:Gonadotropin-induced ovulation in a reptile (Anolis carolinensis): histological observations. 314 17


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