Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0277787 (stigma)
 13,352 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recent research has provided strong support for the existence of a familial risk for suicide, and efforts have been made to separate genetic from enviromental risk factors. Twin studies have played a major role in the identification of genetic factors, and the results indicate that the concordance rate for suicide is higher in identical than in fraternal twins (Baldessarini & Hennen, 2004). Moreover, Segal and Roy (1995) reported a significantly higher frequency of nonfatal suicidal attempts by monozygotic (MZ) than by dyzygotic (DZ) twins whose co-twins had committed suicide. However, doubts remain as to whether the increased risk of suicide in MZ twins is a response to the intense grief over the loss of a close relative, or whether a common genotype is associated with suicidal behavior. Sudden loss, which may carry a stigma in the case of a suicide, has been linked to increased persistent emotional stress and physiological changes (Epstein, 1993; Martin & Dean, 1993). A number of researchers have reported greater suicidal ideation among bereaved MZ twins as compared to DZ twins, suggesting that a loss due to suicide may increase the risk of suicidal behavior in the surviving co-twin (Segal & Bouchard, 1993; Segal & Roy, 1995; Segal et al., 1995). The aim of the present article is to address the issue of the intense grief experienced by twins after the co-twin suicide.
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PMID:Suicidal behavior in surviving co-twins. 1703 44

In this column the author describes the development of an instrument to measure internalized stigma of HIV/AIDS based on the self-concept adaptive mode of the Roy adaptation model. The Internalized Stigma of AIDS Tool is a 10-item instrument that is derived from the physical self (body sensation and image) and personal self (self-consistency, self-ideal and moral-ethical-spiritual self) as set forth by Roy. An overview of the Roy adaptation model and the theory of the person as an adaptive system illustrates how this instrument was derived.
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PMID:Conceptual development of an instrument to measure the internalized stigma of AIDS based on the Roy adaptation model. 2197 76