Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0277787 (stigma)
 13,352 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Poly(A) binding (PAB) proteins play an important role in posttranscriptional regulation by stabilizing mRNA and initiating translation in eukaryotes. Previous studies have shown that the expression of PAB5 gene encoding one of the poly(A) binding proteins (PABPs) in Arabidopsis thaliana is restricted to pollen, ovule and early embryogenesis. To investigate the tissue-specific expression of the PAB5 promoter, a series of promoter deletions (from -1,804, -1,653, -1,334, -1,014, -715, -424 and -175 to +185) were fused to the uidA reporter gene (GUS) and transformed into tobacco plants (Nicotiana tabacum L.). The results showed that GUS expression driven by the full-length PAB5 promoter was detected in floral organs (pollen, ovule, anther, stigma) and immature seeds, but not in vegetative tissues (root, stem, leaf) and mature seeds. Deletion analysis of the PAB5 promoter region revealed that promoters longer than -1,334 had the similar GUS expression level in pollen, ovule and immature seeds, whereas further 5' deletions resulted in a considerable reduction in GUS activity. These results indicated that the region between -1,653 and -1,014 was necessary to direct the tissue-specific expression of PAB5 promoter during development.
 ...
PMID:Functional analysis of the Arabidopsis thaliana poly(A) binding protein PAB5 gene promoter in Nicotiana tabacum. 1877 66

HIV facial lipoatrophy (FLA) is characterized by facial volume loss. HIV FLA affects the facial contours of the cheeks, temples, and orbits, and is associated with social stigma. Although new highly active antiretroviral therapy medications are associated with less severe FLA, the prevalence of HIV FLA among treated individuals exceeds 50%. The goal of our systematic review is to examine published clinical studies involving the use of filler agents for aesthetic treatment of HIV FLA and to provide evidence-based recommendations based on published efficacy and safety data. A systematic review of the published literature was performed on July 1, 2015, on filler agents for aesthetic treatment of HIV FLA. Based on published studies, poly-L-lactic acid is the only filler agent with grade of recommendation: B. Other reviewed filler agents received grade of recommendation: C or D. Poly-L-lactic acid may be best for treatment over temples and cheeks, whereas calcium hydroxylapatite, with a Food and Drug Administration indication of subdermal implantation, may be best used deeply over bone for focal enhancement. Additional long-term randomized controlled trials are necessary to elucidate the advantages and disadvantages of fillers that have different biophysical properties, in conjunction with cost-effectiveness analysis, for treatment of HIV FLA.
...
PMID:A systematic review of filler agents for aesthetic treatment of HIV facial lipoatrophy (FLA). 2648 Oct 56