Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0277787 (
stigma
)
13,352
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A new triterpenoid 3alpha-hydroxy-ursane-5-ene (1) and a known steroid
stigma
sterol (2) have been isolated for the first time from the fruit of Rhazya stricta. The structures of these compounds were elucidated and identified by spectral studies. The crude ethanolic extract of R. stricta fruit has led to the determination of good results of antibacterial, lipoxygenase and acetylcholinesterase activities. In addition, we also reported the acetylcholinesterase activity of
stigma
sterol (2) isolated from this plant.
Stigma
sterol (2) was found to be an acetyl-cholinesterase inhibitor with IC(50) at a concentration of 644.0 +/- 11.75 microM.
Eserine
[(-)-physostigmine, IC(50) = 61 nM)] was used as a positive control.
...
PMID:Phytochemical and enzyme inhibitory studies on indigenous medicinal plant Rhazya stricta. 2022 36
