Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0277787 (stigma)
 13,352 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Collagen and acid glycosaminoglycans (GAG) in bovine tunica albuginea covering the developing follicules (FC) and corpus luteum (CL) were investigated histochemically and biochemically in order to analyze the connective tissue metabolism of the follicular wall as well as to clarify the mechanism involved in stigma repairs after ovulation at the extracellular matrix level. Histochemically, collagen fibers were observed to be loose and sparse by Azan Mallory staining and GAG were markedly stained by alucian blue in large FC. Biochemically, hydroxyproline content showed a significant decrease (43%) in large FC compared with control tunica albuginea. Uronic acid and hexosamine content tended to increase in large FC, compared with small FC. The major GAG component in FC was sulfate GAG, consisting mainly of dermatan sulfate (DS). The DS component ratio and concentration were decreased significantly in large FC, compared with small FC. Remodelling of collagen fibers and an increase in GAG content were observed in CL. The increase in GAG content was caused by a threefold increase in the component ratio and concentration of hyaluronic acid in CL, compared with other tunica albuginea. These results suggest that changes in GAG components in FC and CL are strongly related to collagen metabolism in tunica albuginea during the ovulatory cycle.
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PMID:[Collagen and acid glycosaminoglycans in bovine tunica albuginea during ovulatory cycle]. 227 5