Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0277787 (stigma)
 13,352 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study involved the screening for dermal microcirculatory abnormalities using periungueal capillaroscopy in a group of 80 cases of rheumatoid arthritis, so-defined in terms of ARA criteria. Excessive erythrocyte aggregation and/or pericapillary edema were detected in 74% of cases and were statistically correlated with ESR, reflecting an inflammatory syndrome. Capillary neogenesis, probably in reaction to subclinical cutaneous vascularity, was detected in 59% of cases (86% of subjects presenting extra-articular rheumatism). In 28% of cases this was accompanied by spontaneous hemorrhage, suggesting a progressive condition. Stigmata of cutaneous atrophy were present in 54% of subjects. These findings demonstrate the frequency of subclinical cutaneous damage in rheumatoid disease and suggest the possibility of the clinical usefulness of capillaroscopy, a non-invasive technic, in the follow-up of this disease.
Rev Rhum Mal Osteoartic 1986 Jun
PMID:[Periungual capillaroscopy in rheumatoid arthritis. Prospective study of 80 cases]. 242 62

Mal de Debarquement Syndrome is a neurological disorder of motion perception, triggered by external motion. This study aimed to determine the importance of psychosocial factors in relation to depression and quality of life in Mal de Debarquement Syndrome. A total of 66 participants with self-reported Mal de Debarquement Syndrome completed quality-of-life, symptom severity, stigma, depression, and illness intrusiveness measurements in this naturalistic correlational study. Mal de Debarquement Syndrome was associated with high levels of depression and illness intrusiveness. Illness intrusiveness mediated between stigma and quality of life; also the level of stigma moderated the effect of illness intrusiveness on quality of life. Targeted interventions aimed at alleviating psychological distress may improve quality of life in Mal de Debarquement Syndrome.
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PMID:The relationship between symptom severity, stigma, illness intrusiveness and depression in Mal de Debarquement Syndrome. 2533 14