Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0271742 (AAA)
 3,032 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Simple sequences present in long (> 30 kb) sequences representative of the single-copy genome of five species (Homo sapiens, Caenorhabditis elegans, Saccharomyces cerevisiae, E. coli, and Mycobacterium leprae) have been analyzed. A close relationship was observed between genome size and the overall level of sequence repetition. This suggested that the incorporation of simple sequences had accompanied increases of genome size during evolution. Densities of simple sequence motifs were higher in noncoding regions than in coding regions in eukaryotes but not in eubacteria. All five genomes showed very biased frequency distributions of simple sequence motifs in all species, particularly in eukaryotes where AAA and TTT predominated. Interspecific comparisons showed that noncoding sequences in eukaryotes showed highly significantly similar frequency distributions of simple sequence motifs but this was not true of coding sequences. ANOVA of the frequency distributions of simple sequence motifs indicated strong contributions from motif base composition and repeat unit length, but much of the variation remained unexplained by these parameters. The sequence composition of simple sequences therefore appears to reflect both underlying sequence biases in slippage-like processes and the action of selection. Frequency distributions of simple sequence motifs in coding sequences correlated weakly or not at all with those in noncoding sequences. Selection on coding sequences to eliminate undesirable sequences may therefore have been strong, particularly in the human lineage.
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PMID:The contribution of slippage-like processes to genome evolution. 858 2

The purpose of our study was to evaluate the influence of perirenal fixation of endovascular aortic grafts on the rate of endoleak and aortic sac remodeling. Retrospective analysis of all patients (pts.) after undergoing endovascular aortic aneurysm repair (EVAR) at our institution was performed. Pre- and postoperative aortic dimensions were obtained from CT scans and angiograms. Intraoperative angiograms were reviewed and patients grouped by the proximity of the graft to the lowest renal arteries: group I: flush with the lowest renal artery; group II: < or = 5 mm distal to lowest renal artery; and group III: >5 mm distal to lowest renal artery. Of the 96 grafts placed between 2000 and 2002, 44 were AneuRx (Medtronic, Santa Rosa, CA) and 52 were Ancure (Guidant, Menlo Park, CA) devices. There were 39 pts. in group I, 42 in group II, and 11 in group III (data on 5 pts. were not obtained). At 6 months, the mean decrease in sac diameter for all groups was 0.42 +/- 0.08 cm (1: 0.56 +/- 0.11 cm; 11: 0.38 +/- 0.11 cm; III: 0.6 +/- 0.15 cm). There was no significant difference between each group. When perirenal fixation (group I) was compared with nonperirenal fixation (groups II and III), there was a significant difference in sac shrinkage at 6 months (p < 0.05, ANOVA). Group I had shorter necks and smaller aneurysms (2.2 +/- 0.1 cm and 5.3 +/- 0.1 cm) than those of groups II and III (2.7 +/- 0.1 cm and 5.7 +/- 0.1 cm, p < 0.05, ANOVA). There was no difference in aortic neck diameter or in aortic neck diameter to graft ratio. When controlled for the variables studied (AAA diameter, length of neck, diameter of neck, diameter of neck to graft ratio, and any endoleak by 6 months), logistic regression analysis identified perirenal fixation as the only significant factor in aortic sac shrinkage of >0.4 cm by 6 months (odds ratio = 16, p < 0.01). With the same variables, a linear regression model also identified perirenal fixation as the only predictive factor in aortic shrinkage (regression coefficient = 0.46, p < 0.05). The endoleak-free survival rate with perirenal fixation was 96 +/- 5% and without it was 80 +/- 7% (Kaplan Meier, p = 0.09, log rank). Perirenal placement of endovascular grafts is associated with a trend toward fewer endoleaks, and improved aortic sac shrinkage independent of aortic neck length, AAA diameter, diameter of neck, and endoleak. Failure to achieve perirenal placement of EVAG increased the likelihood of reduced or failed aortic sac shrinkage in this series.
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PMID:Perirenal fixation as an independent factor in aortic remodeling after endovascular aortic aneurysm repair. 1525 46

Seasonal and circadian variation in the incidence of ruptured abdominal aortic aneurysm (RAAA) has been reported. We explored the role of atmospheric pressure changes on rupture incidence and its relationship to cardiovascular risk factors. During a three year-period, 1st April 1998 and 31st March 2001, data was prospectively acquired on 144 Ruptured Abdominal Aortic Aneurysm (RAAA) presenting to the Regional Vascular Surgery Unit at the Royal Victoria Hospital, Belfast, Northern Ireland. For each patient the chronology of acute onset of symptoms and presentation to the regional vascular unit was recorded, along with details of standard cardiovascular risk factors. During the same period meteorological data including atmospheric pressure and air temperature were recorded daily at the regional meteorological research unit, Armagh. We then analyzed the monthly mean values for daily rupture incidence in relation to the monthly values for atmospheric pressure, pressure change and temperature. Furthermore atmospheric pressure on the day of rupture, and day preceding rupture, were also analyzed in relation to days without rupture presentation and between individual ruptures for various cardiovascular risk factors. Data demonstrated a significant monthly variation in aneurysm rupture frequency, (p<0.03, ANOVA). There was also a significant monthly variation in mean barometric atmospheric pressure, (p<0.0001, ANOVA), months with high rupture frequency also exhibiting low average pressures in the months of April (0.24 +/- 0.04 ruptures per day and 1007.78 +/- 1.23 mB) and September (0.16 +/- 0.04 ruptures per day and 1007.12 +/- 1.14 mB), respectively. The average barometric pressures were found to be significantly lower on those days when ruptures occurred (n=1127) compared to days when ruptures did not occur (n=969 days), (1009.98 +/- 1.11 versus 1012.09 +/- 0.41, p<0.05). Full data on risk factors was available on 103 of the 144 rupture patients and was further analyzed. Interestingly, RAAA with a known history of hypertension, (n=43), presented on days with significantly lower atmospheric pressure than those without, (n=60), (1008.61 +/- 2.16 versus 1012.14 +/- 1.70, p<0.05). Further analysis of ruptures grouped into those occurring on days above or below mean annual atmospheric pressure 1013.25 (approximately 1 atmosphere), by Chi-square test, revealed three cardiovascular risk factors significantly associated with low-pressure rupture, (p<0.05). Data represents mean +/- SEM, statistical comparisons with Student t-test and ANOVA. These data demonstrate a significant association between periods of low barometric pressure and high incidence of ruptured aneurysm, especially in those patients with known hypertension. The association between rupture incidence and barometric pressure warrants further study as it may influence the timing of elective AAA repair.
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PMID:Periods of low atmospheric pressure are associated with high abdominal aortic aneurysm rupture rates in Northern Ireland. 1623 64

Dose verification as part of plan checking is a critical component of high quality patient care. IMSure QA is a software platform used at the BC Cancer Agency that facilitates dose verification for both conformal and IMRT plans. We have recently initiated treating breast tangents using IMRT at the Fraser Valley Centre and noted increased dose discrepancies (mean difference of -3%) between Eclipse and IMSure's QA module. We identified two potential sources of error: air flash and tissue heterogeneity. We extend our generated fluences 3cm past the breast contour and into air to account for breathing, set-up uncertainties and swelling. IMSure does not account for the fluence in air or air flash. We present an air-flash-correction factor based on the ratios of TMRs and Phantom Scatter Factors which use the field sizes of fields with and without the air flash. In addition, we present a method to improve the heterogeneity correction used by IMSure to better match that used by AAA. Effectively we remove the IMSure's inherent heterogeneity correction and manually apply a AAA-based heterogeneity-correction factor. We evaluated our correction factors on a sample of 8 patients (32 fields) using ANOVA methods to determine which dose corrections most accurately reproduce Eclipse's values. We found the air-flash correction coupled with IMSure's inherent-heterogeneity correction has the best dose accuracy (mean difference improved from -3% to 0.3%). The AAA-heterogeneity correction alone also improved the accuracy (mean difference improved from -3% to - 1.5%), which is acceptable for plan checking purposes.
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PMID:Poster - Thur Eve - 71: Improved dose accuracy for plan checking IMRT breast plans. 2851 49