Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0271276 (Hudson)
 1,066 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Persons with developmental disabilities are more frequently abused physically, emotionally and sexually than nondisabled persons (Ammerman, Van-Hasselt, Herson, McGonigle, & Lubetsky, 1989; Sobsey, Gray, Pyper, & Reimer-Heck, 1991). Persons with developmental disabilities are susceptible to the full range of psychiatric disorders (Szymanski, Madow, Mallory, Menolascino, & Pace, 1991). There has been no comprehensive study of posttraumatic stress disorder (PTSD) in this population (Hudson & Pilek, 1990), a recent textbook of mental health and mental retardation does not contain index listings on this condition (Fletcher & Menolascino, 1989), and psychometric tests currently proposed for use with the retarded do not examine for this condition (Aman, Watson, Singh, Turbott, & Wilsher, 1986). In this preliminary study, descriptive data from 51 persons with developmental disabilities who met DSM-IIIR criteria for posttraumatic stress disorder are reported. The majority of cases were detected upon routine initial psychiatric interview and record review. Demographics, family histories, and comorbid psychiatric conditions are described. In this sample all patients who received comprehensive recommended treatment improved.
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PMID:Posttraumatic stress disorder in persons with developmental disabilities. 814 22

The growth of Gluconobacter oxydans DSM 7145 on meso-erythritol is characterized by two stages: in the first stage, meso-erythritol is oxidized almost stoichiometrically to L-erythrulose according to the Bertrand-Hudson rule. The second phase is distinguished from the first phase by a global metabolic change from membrane-bound meso-erythritol oxidation to L-erythrulose assimilation with concomitant accumulation of acetic acid. The membrane-associated erythritol-oxidizing enzyme was found to be encoded by a gene homologous to sldA known from other species of acetic acid bacteria. Disruption of this gene in the genome of G. oxydans DSM 7145 revealed that the membrane-bound polyol dehydrogenase not only oxidizes meso-erythritol but also has a broader substrate spectrum which includes C3-C6 polyols and D-gluconate and supports growth on these substrates. Cultivation of G. oxydans DSM 7145 on different substrates indicated that expression of the polyol dehydrogenase was not regulated, implying that the production of biomass of G. oxydans to be used as whole-cell biocatalysts in the biotechnological conversion of meso-erythritol to L-erythrulose, which is used as a tanning agent in the cosmetics industry, can be conveniently carried out with glucose as the growth substrate.
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PMID:Characterization and inactivation of the membrane-bound polyol dehydrogenase in Gluconobacter oxydans DSM 7145 reveals a role in meso-erythritol oxidation. 2022 2