Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0270736 (
Essential tremor
)
404
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
LINGO1 is a
transmembrane protein
that is up-regulated in the cerebellum of patients with Parkinson's disease (PD) and
Essential Tremor
(ET). Patients with additional copies of the LINGO1 gene also present with tremor. Pharmacological or genetic ablation of large conductance Ca
2+
-activated K
+
(BK) channels also result in tremor and motor disorders. We hypothesized that LINGO1 is a regulatory BK channel subunit. We show that 1) LINGO1 coimmunoprecipitated with BK channels in human brain, 2) coexpression of LINGO1 and BK channels resulted in rapidly inactivating BK currents, and 3) LINGO1 reduced the membrane surface expression of BK channels. These results suggest that LINGO1 is a regulator of BK channels, which causes a "functional knockdown" of these currents and may contribute to the tremor associated with increased LINGO1 levels.
...
PMID:LINGO1 is a regulatory subunit of large conductance, Ca
2+
-activated potassium channels. 3193 43
