Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0268596 (EMA)
 2,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a case of neuroendocrine tumour of the uterine cervix (carcinoid) with spread to the corpus and adnexa, and hepatic metastases. Carcinoid represents a rare entity among tumours of the uterine cervix, and is now included among the APUD system-derived tumours (apudomas). Gross examination revealed an enlarged uterus (11 x 7 cm) with neoplastic infiltration of the endocervical canal and uterine corpus, and yellowish-white nodules in both ovaries. Microscopic features were those of a malignant trabecular carcinoid (Morson's type I-II). Morphological, histochemical, immunohistochemical and ultrastructural studies were performed. Grimelius stain and antisera to NSE and bombesin yielded positive reactions. Focal positivity was seen with EMA, and probably expressed an epidermoid component. On the basis of a review of the literature, we classify our case within the differentiated neuroectodermic tumours, despite the extremely aggressive biologic behavior already present at surgery. Combined use of histochemical, immunohistochemical and ultrastructural techniques is the correct approach to the histopathologic diagnosis of malignancies with rare and difficult features.
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PMID:Neuroendocrine tumour of the uterine cervix. Cytomorphologic, histochemical and immunohistochemical aspects. 275 64

In an unselected series of 32 biopsies of pulmonary neoplasms comprising 25 with neuroendocrine differentiation (11 carcinoids, 9 small cell cancers, and 5 undifferentiated carcinomas) a panel of antibodies (chromogranin-CG, neuron specific enolasis-NSE, S-100 protein, serotonin, bombesin, cytokeratins AE1-3, CAM5.2, epithelial membrane antigen-EMA) was used. This set was compared with results in another series of 7 non-small cell cancers (4 spinocellular and 3 adenomatous). The results of investigation of both the series were in agreement with the fact that there is no completely satisfactory marker of neuroendocrine differentiation. That is the reason why it is the best to use a spectrum of antibodies even in the routine praxis, as the proof of this differentiation in a neoplasm is most important for the differential diagnosis as well as for the therapy and prognosis.
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PMID:[Use of immunohistochemical markers in the diagnosis of bronchogenic tumors]. 871 93