Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0268596 (
EMA
)
2,520
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Increasing evidence indicates that guidance molecules used during development for cellular and axonal navigation also play roles in synapse maturation and homeostasis. In C. elegans the netrin receptor UNC-40/DCC controls the growth of dendritic-like muscle cell extensions towards motoneurons and is required to recruit type A GABA receptors (GABA
A
Rs) at inhibitory neuromuscular junctions. Here we show that activation of UNC-40 assembles an intracellular synaptic scaffold by physically interacting with FRM-3, a FERM protein orthologous to FARP1/2. FRM-3 then recruits LIN-2, the ortholog of
CASK
, that binds the synaptic adhesion molecule NLG-1/Neuroligin and physically connects GABA
A
Rs to prepositioned NLG-1 clusters. These processes are orchestrated by the synaptic organizer CePunctin/
MADD
-4, which controls the localization of GABA
A
Rs by positioning NLG-1/neuroligin at synapses and regulates the synaptic content of GABA
A
Rs through the UNC-40-dependent intracellular scaffold. Since DCC is detected at GABA synapses in mammals, DCC might also tune inhibitory neurotransmission in the mammalian brain.
...
PMID:The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABA
A
receptors. 3247 87
