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Query: UMLS:C0268596 (EMA)
 2,520 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eighteen cases of anaplastic meningioma were studied by LM, EM and immunohistochemistry for vimentin, EMA, keratin, GFAP and S-100. Microscopically, there were four histologic types, i.e. fibrosarcoma-like, angiosarcoma-like, polymorphic giant cell sarcoma-like and angiopapillary structure. By EM, four kinds of cells: undifferentiated cell, intermediate transitional cell, spindle-shaped cell, and giant cell, were found and variant transitions from undifferentiated or poorly, differentiated to meningioma cells were observed. Their ultrastructures and immunohistochemical features are similar to those of malignant mesothelioma. Since these two kinds of neoplasm showed both mesenchymal and epithelial cells in the features, the authors consider that their histogenesis may also be similar.
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PMID:[The ultrastructural and immunohistochemical observations of anaplastic meningioma]. 128 91

Six cases of extracranial meningioma (EM) are reported. In addition to the routine paraffin section and HE stain as examined by light microscope, immuno-histochemical studies with antibodies against vimentin, EMA, CK1, and S-100 were done. One specimen was examined by electron microscopy as well. For subdivision, 4 belonged to meningotheliomatous type and each of the rest belonged to transitional and psammomatous types respectively. According to Lopez's classification, 5 were Type II and 1 was Type III. The significance of Lopez's classification of this tumor in clinical diagnosis and differential diagnosis, in histogenesis and pathogenesis are discussed.
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PMID:[Extracranial meningioma--a report of 6 cases]. 139 78

Two-hundred-and-eighty meningiomas of the surgical pathological files of the Taipei Veterans General Hospital from the period 1976-1986 were reviewed by the authors without prior knowledge of clinical circumstances or outcome. Thirty-four cases were regarded as atypical or anaplastic based on high cellularity, pleomorphism and the presence of mitotic figures with 6 cases showing only the above features and the remaining 28 displaying in addition one or more of the following "ominous" variables: papillary formation, necrosis and invasion of the underlying brain. With a median follow-up of three years after surgery the recurrence rate was 44% (15 cases) for this group of tumors whereas the remaining 246 histologically benign meningiomas had a 6% recurrence rate during the same period. This difference was statistically significant (p less than 0.0001). Once the atypical or anaplastic character of a meningioma was established, no difference in the recurrence rate was found related to the number of mitoses and whether the additional ominous variables were present, alone or in conjunction with others. Immunostaining for vimentin, S100, fibronectin and EMA showed variable results in the 34 atypical meningiomas but without significant difference between those that recurred within 3 years and the ones that did not.
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PMID:Atypical (anaplastic) meningioma: relationship between histologic features and recurrence--a clinicopathologic study. 218 42

We present an immunohistochemical study of 16 meningiomas and 19 CNS tumors including gliomas, neurinomas and metastatic carcinomas, in order to establish a histopathologic differential diagnosis, using formalin-fixed and paraffin-embedded material. The antibodies analysed included vimentin, GFA-protein, cytokeratin, S-100 protein and epithelial membrane antigen. Meningiomas always express vimentin as marker, and occasionally cytokeratin and EMA. The most constant antigens demonstrated in astrocytomas were GFA-protein and vimentin, and occasionally we were able to detect S-100 protein. Neurinomas proved positive to S-100 protein, and metastases presented cytokeratin and EMA reactivity. Our results confirm the existence of diverse immunohistochemical patterns within CNS tumors, a fact that can be useful in routine differential diagnosis.
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PMID:[Differential immunohistochemical characteristics of meningiomas and other neoplasms of the central nervous system]. 263 47

Seventy-six cases of meningioma of various light microscopic features were studied immunohistochemically by using 6 kinds of antibodies directly against epithelial, mesenchymal and neural components. Except for hemangiopericyte meningiomas which only showed vimentin positive, expressions of vimentin and EMA were obtained in almost all the meningiomas. Thirteen meningiomas were investigated by electron microscopy. The electron micrograph of meningiomatous cell showed presence of interdigitation of the adjacent cell membrane with desmosome and variable amounts of intermediate filaments in cytoplasm, although the re were different varieties of cell types. 2 hemangiopericyte meningiomas showed presence of different ultrastructures, which contained many pericytes and cells with a large number of RER. These results provide evidences of the fact that meningioma possessed the features of both mesenchymal and epithelial tissue. In regard to histogenesis, findings reported suggest that meningioma most probably arise from the arachnoid cap cells. Additionally, some distinct subtypes of meningioma are reported, including secretory meningioma, microcystic meningioma and oncocytic meningioma.
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PMID:[An immunohistochemical and ultrastructural study on 76 cases of meningioma]. 263 60

Four cases of perineurioma (storiform perineurial fibroma) arising in the dermis, subcutis, or deep soft tissue have been studied. Two patients were female and two were male with ages ranging from 19 to 45 years. One lesion each arose on the chest wall, shoulder, neck, and elbow. Follow-up information in three patients revealed no recurrence. Histologically, the neoplasms were circumscribed but non-encapsulated lesions and were composed of spindle cells with elongated bipolar cytoplasmic processes, inconspicuous fusiform nuclei and well-defined palely eosinophilic cytoplasm. These cells were arranged in whorls or lamellar-like structures and often demonstrated a storiform growth pattern. In areas, the tumour cells appeared larger with more rounded nuclei. Immunohistochemically, most of the tumour cells stained positive for epithelial membrane antigen and vimentin, but failed to stain for S-100 protein, neurofilament, desmoplakin, and CD34. Ultrastructurally, two cases showed fusiform tumour cells with long, thin cell processes separated by abundant collagen bundles. Tumour cells were covered by discontinuous external lamina, showed many pinocytic vesicles and occasionally desmosome-like structures. The morphology and EMA immunopositivity of perineurioma are similar to meningioma, especially to cutaneous meningioma type II. We believe that perineurioma and meningioma are closely related, but morphologically distinguishable, neoplasms.
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PMID:Perineurioma (storiform perineurial fibroma): clinico-pathological analysis of four cases. 782 94

To our knowledge this is the first reported case of a primary extracranial meningioma located in the palatine tonsil. Immunohistochemical investigation of the tumour showed coexpression of vimentin and neuron-specific enolase (NSE). No staining was found with antibodies against cytokeratins KL1, 13/10, 8 and 18, epithelial membrane antigen EMA and melanoma protein (HMB-45). It seems justifiable to classify this tumour as an atypical meningioma because of the local increased mitotic activity.
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PMID:[Ectopic meningioma of the tonsil]. 924 77

Forty-nine cases of the so-called "angioblastic meningioma", six cases of cerebellar hemangioblastoma, and four cases of soft tissue hemangiopericytoma were studied with HE, reticulin stainings, and immunohistochemical reaction with Vimentin, EMA, GFAP, S-100, and UEA-1 antibodies. The results showed that among the three subtypes of "angioblastic meningioma", namely, the hemangiomatous (H), the hemangioblastic (AB), and the hemangiopericytic (P) types, (1) type H belongs to true meningioma; (2) most of type P are almost identical with soft tissue hemangiopericytoma and different from true meningiomas, therefore belong to hemangiopericytoma arising from pericytes; however (3) some true meningiomas may appear as hemangiopericytoma histologically; (4) a few of AB are very similar to cerebellar hemangioblastoma and thus should be considered as supratentorial hemangioblastoma, while most of AB are still true meningiomas.
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PMID:[A comparative study of "angioblastic meningioma", hemangiopericytoma and cerebellar hemangioblastoma]. 834 Jan 1

We report herein on a case of clear cell meningioma originating from the cerebellar tentorium, surgically treated by occipital transtentorial approach (OTT). A 67-year-old woman was admitted to our hospital in September, 1996, complaining of gait disturbance. MRI revealed an isointense mass on T1 and T2 WI, clearly enhanced with gadolinium in the right upper cerebellum originating from the tentorium. A left vertebral angiogram showed tumor stain from the right superior cerebellar artery. The tumor was subtotally removed by OTT on September 24, 1996. Gamma knife radiosurgery was performed for regrowing tumor 6 months after surgery. Histological examination revealed that the tumors were composed of sheets of clear, glycogen-rich cells and lobulated by thin connective tissues. There were no malignant findings, but some tumor cells had infiltrated into the cerebellar cortex. Immunohistochemistry showed that tumor cells were positive for EMA and vimentin, but negative for keratin. MIB-1 staining index was 7.02%. From these findings, this case was diagnosed as a typical clear cell meningioma originating from the cerebellar tentorium. From a review of the literature including our case, clear cell meningioma may be clinicopathologically malignant, so careful follow-up will be necessary.
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PMID:[A case of clear cell meningioma originating from the cerebellar tentorium]. 955 60

Among the histological variants of meningiomas the oncocytic subtype is rarely observed. Up-today, only six cases of oncocytic meningioma are described. This subtype of meningiomas shows an aggressive behavior and recurrences are more frequent. We describe a case of oncocytic meningioma in a 78-years-old woman. The patient had a history of breast cancer diagnosed 9 years before the brain biopsy; bilateral mastectomy and adjuvant chemotherapy was performed. She had a right frontal tumour measuring 3 cm in diameter. The patient is alive and well eleven months after surgery. The tumour was composed by large polygonal neoplastic cells with finely granular eosinophilic cytoplasm. Neoplastic cells were arranged in sheets and nests delimited by thin fibrous septa rich in vessels. Psammomatous bodies were also present. Mitoses were rare and necrosis was absent. Oncocytic differentiation was demonstrated by conventional histology and immunohistochemistry. Immunohistochemistry revealed a strong and diffuse positivity for antimitochondrial antiserum, vimentin and EMA; a focal reactivity for cytokeratin was observed. The rarity of oncocytic meningiomas is underlined with only six cases described in the world literature. The immunophenotypic profile and the differential diagnosis of the neoplasm is discussed and the concept of oncocytic meningioma as a distinct entity of tumour is emphasized.
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PMID:[Oncocytic meningioma. Case report]. 1083 73


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